PMID- 26514518
OWN - NLM
STAT- MEDLINE
DCOM- 20160913
LR  - 20220408
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 16
IP  - 16
DP  - 2015
TI  - Association of the -2518 A/G Polymorphism of MCP-1 with Breast Cancer in Punjab, 
      North-West India.
PG  - 7243-8
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) is a major chemokine 
      thought to be responsible for monocyte and T-lymphocyte recruitment in acute 
      inflammatory conditions and recruitment of macrophages in tumors. It is also 
      implicated in cardiovascular disease, rheumatoid arthritis and chronic 
      obstructive pulmonary disease. The aim of the present study was to investigate 
      the correlation between MCP-1 -2518 A/G polymorphism and breast cancer risk in 
      patients from Amritsar city of Punjab state in North-West India. MATERIALS AND 
      METHODS: We screened DNA samples of 200 sporadic breast cancer patients and 200 
      age and gender matched unrelated healthy individuals for MCP-1 -2518 A/G 
      polymorphism using the PCR-RFLP method. RESULTS: A significantly increased 
      frequency of the GG genotype was observed in patients as compared to controls. 
      Individuals carrying the MCP1 -2518GG genotype had a two fold risk for breast 
      cancer (OR=2.06, 95%CI, 1.06-3.98; p=0.03). Genetic models analysis revealed a 
      significant association between MCP-1 -2518 A/G polymorphism and cancer risk in 
      homozygous co-dominant (OR=2.06, 95%CI, 1.06-3.98; p=0.03) and recessive 
      (OR=1.97, 95%CI, 1.05-3.70; p=0.03) models. CONCLUSIONS: We conclude that the GG 
      genotype of the MCP-1-2518 A/G polymorphism is associated with increased risk to 
      breast cancer in Punjab, North-West India.
FAU - Sambyal, Vasudha
AU  - Sambyal V
AD  - Human Cytogenetics Laboratory, Department of Human Genetics, Guru Nanak Dev 
      University, Amritsar, Punjab, India E-mail : guleria_k@yahoo.com.
FAU - Guleria, Kamlesh
AU  - Guleria K
FAU - Kapahi, Ruhi
AU  - Kapahi R
FAU - Manjari, Mridu
AU  - Manjari M
FAU - Sudan, Meena
AU  - Sudan M
FAU - Uppal, Manjit Singh
AU  - Uppal MS
FAU - Singh, Neeti Rajan
AU  - Singh NR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*genetics
MH  - Breast Neoplasms/*genetics/pathology
MH  - Carcinoma, Ductal, Breast/*genetics/pathology
MH  - Carcinoma, Lobular/*genetics/pathology
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - India
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Prognosis
EDAT- 2015/10/31 06:00
MHDA- 2016/09/14 06:00
CRDT- 2015/10/31 06:00
PHST- 2015/10/31 06:00 [entrez]
PHST- 2015/10/31 06:00 [pubmed]
PHST- 2016/09/14 06:00 [medline]
AID - 10.7314/apjcp.2015.16.16.7243 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2015;16(16):7243-8. doi: 10.7314/apjcp.2015.16.16.7243.