PMID- 26514557 OWN - NLM STAT- MEDLINE DCOM- 20160829 LR - 20181202 IS - 1432-2072 (Electronic) IS - 0033-3158 (Linking) VI - 233 IP - 3 DP - 2016 Feb TI - Behavioral and neurochemical effects induced by reserpine in mice. PG - 457-67 LID - 10.1007/s00213-015-4118-4 [doi] AB - RATIONALE: Reserpine, a monoamine-depleting agent, which irreversibly and non-selectively blocks the vesicular monoamine transporter, has been used as an animal model to study several neurological disorders, including tardive dyskinesia and Parkinson's disease. OBJECTIVE: The purpose of this study was to examine if motor deficits induced by reserpine in mice could be related to alterations in the expression of dopaminergic system proteins such as tyrosine hydroxylase (TH) and dopamine transporter (DAT) and in the activity of monoamine oxidase (MAO). METHODS: Mice received either vehicle or reserpine (0.1, 0.5, or 1 mg/kg, s.c.) for four consecutive days. Two, 20, or 60 days after reserpine withdrawal, behavioral, and neurochemical changes were evaluated. RESULTS: Reserpine at a dose of 0.5 and 1 mg/kg increased vacuous chewing movements (VCMs) and reduced locomotion. Behavioral changes were accompanied by reduction in TH immunoreactivity in the striatum evaluated on days 2 and 20 after the last injection of 1 mg/kg reserpine. Furthermore, negative correlations were found between VCM and MAO-A or MAO-B on day 2 and TH striatal immunoreactivity on day 20 after the last injection of 1 mg/kg reserpine. A positive correlation was observed between VCMs and DAT immunoreactivity in the substantia nigra on day 2 after the last injection of 0.5 mg/kg reserpine. CONCLUSIONS: These findings suggest that the pharmacological blockage of vesicular monoamine transporter (VMAT) by reserpine caused neurochemical and behavioral alterations in mice. FAU - de Freitas, Catiuscia Molz AU - de Freitas CM AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica Toxicologica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. FAU - Busanello, Alcindo AU - Busanello A AD - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. FAU - Schaffer, Larissa Finger AU - Schaffer LF AD - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. FAU - Peroza, Luis Ricardo AU - Peroza LR AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica Toxicologica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. FAU - Krum, Barbara Nunes AU - Krum BN AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica Toxicologica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. FAU - Leal, Caroline Queiroz AU - Leal CQ AD - Curso de Farmacia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. FAU - Ceretta, Ana Paula Chiapinotto AU - Ceretta AP AD - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. FAU - da Rocha, Joao Batista Teixeira AU - da Rocha JB AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica Toxicologica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. FAU - Fachinetto, Roselei AU - Fachinetto R AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica Toxicologica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. roseleirf@gmail.com. AD - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. roseleirf@gmail.com. AD - Departamento de Fisiologia e Farmacologia, Centro de Ciencias da Saude, 97105-900, Santa Maria, RS, Brazil. roseleirf@gmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20151030 PL - Germany TA - Psychopharmacology (Berl) JT - Psychopharmacology JID - 7608025 RN - 0 (Adrenergic Uptake Inhibitors) RN - 0 (Dopamine Plasma Membrane Transport Proteins) RN - 0 (Slc6a3 protein, mouse) RN - 8B1QWR724A (Reserpine) RN - EC 1.14.16.2 (Tyrosine 3-Monooxygenase) RN - EC 1.4.3.4 (Monoamine Oxidase) RN - VTD58H1Z2X (Dopamine) SB - IM MH - Adrenergic Uptake Inhibitors/*pharmacology MH - Animals MH - Behavior, Animal/*drug effects MH - Brain Chemistry/*drug effects MH - Corpus Striatum/drug effects/enzymology MH - Dopamine/physiology MH - Dopamine Plasma Membrane Transport Proteins/drug effects/metabolism MH - Dose-Response Relationship, Drug MH - Male MH - Mastication/drug effects MH - Mice MH - Monoamine Oxidase/metabolism MH - Motor Activity/drug effects MH - Reserpine/*pharmacology MH - Substantia Nigra/drug effects/metabolism MH - Tyrosine 3-Monooxygenase/metabolism OTO - NOTNLM OT - Dopamine OT - Dopamine transporter OT - Parkinson's disease OT - Tardive dyskinesia OT - Tremulous jaw movements OT - Tyrosine hydroxylase EDAT- 2015/10/31 06:00 MHDA- 2016/08/30 06:00 CRDT- 2015/10/31 06:00 PHST- 2014/12/10 00:00 [received] PHST- 2015/10/15 00:00 [accepted] PHST- 2015/10/31 06:00 [entrez] PHST- 2015/10/31 06:00 [pubmed] PHST- 2016/08/30 06:00 [medline] AID - 10.1007/s00213-015-4118-4 [pii] AID - 10.1007/s00213-015-4118-4 [doi] PST - ppublish SO - Psychopharmacology (Berl). 2016 Feb;233(3):457-67. doi: 10.1007/s00213-015-4118-4. Epub 2015 Oct 30.