PMID- 26515234
OWN - NLM
STAT- MEDLINE
DCOM- 20160523
LR  - 20181113
IS  - 1365-2613 (Electronic)
IS  - 0959-9673 (Print)
IS  - 0959-9673 (Linking)
VI  - 96
IP  - 5
DP  - 2015 Oct
TI  - Immunohistochemical expression of matrix metalloproteinase-1, matrix 
      metalloproteinase-2 and matrix metalloproteinase-9, myofibroblasts and Ki-67 in 
      actinic cheilitis and lip squamous cell carcinoma.
PG  - 311-8
LID - 10.1111/iep.12140 [doi]
AB  - Matrix metalloproteinases (MMPs), myofibroblasts (MFs) and epithelial 
      proliferation have key roles in neoplastic progression. In this study 
      immunoexpression of MMP-1, MMP-2 and MMP-9, presence of MFs and the epithelial 
      proliferation index were investigated in actinic cheilitis (AC), lip squamous 
      cell carcinoma (LSCC) and mucocele (MUC). Thirty cases of AC, thirty cases of 
      LSCC and twenty cases of MUC were selected for immunohistochemical investigation 
      of the proteins MMP-1, MMP-2, MMP-9, alpha-smooth muscle actin (alpha-SMA) and Ki-67. The 
      MMP-1 expression in the epithelial component was higher in the AC than the MUC 
      and LSCC. In the connective tissue, the expression was higher in the LSCC. MMP-2 
      showed lower epithelial and stromal immunostaining in the LSCC when compared to 
      the AC and MUC. The epithelial staining for MMP-9 was higher in the AC when 
      compared to the LSCC. However, in the connective tissue, the expression was lower 
      in the AC compared to other lesions. The cell proliferation rate was increased in 
      proportion to the severity of dysplasia in the AC, while in the LSCC it was 
      higher in well-differentiated lesions compared to moderately differentiated. 
      There were no statistically significant differences in number of MFs present in 
      the lesions studied. The results suggest that MMPs could affect the biological 
      behaviour of ACs and LSCCs inasmuch as they could participate in the development 
      and progression from premalignant lesions to malignant lesions.
CI  - (c) 2015 The Authors. International Journal of Experimental Pathology (c) 2015 
      International Journal of Experimental Pathology.
FAU - Bianco, Bianca C
AU  - Bianco BC
AD  - Federal University of Santa Catarina, Florianopolis, Brazil.
FAU - Scotti, Fernanda M
AU  - Scotti FM
AD  - Federal University of Santa Catarina, Florianopolis, Brazil.
FAU - Vieira, Daniella S C
AU  - Vieira DS
AD  - Pathology Department, Federal University of Santa Catarina, Florianopolis, 
      Brazil.
FAU - Biz, Michelle T
AU  - Biz MT
AD  - Morphology Sciences Department and Dentistry Graduate Program, Federal University 
      of Santa Catarina, Florianopolis, Brazil.
FAU - Castro, Renata G
AU  - Castro RG
AD  - Dentistry Department, Federal University of Santa Catarina, Florianopolis, 
      Brazil.
FAU - Modolo, Filipe
AU  - Modolo F
AUID- ORCID: 0000-0002-5395-0486
AD  - Pathology Department and Dentistry Graduate Program, Federal University of Santa 
      Catarina, Florianopolis, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151030
PL  - England
TA  - Int J Exp Pathol
JT  - International journal of experimental pathology
JID - 9014042
RN  - 0 (Ki-67 Antigen)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
RN  - Actinic cheilitis
SB  - IM
MH  - Carcinoma, Squamous Cell/metabolism/*pathology
MH  - Cheilitis/metabolism/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Ki-67 Antigen/biosynthesis
MH  - Lip Neoplasms/metabolism/*pathology
MH  - Matrix Metalloproteinase 1/analysis/biosynthesis
MH  - Matrix Metalloproteinase 2/analysis/biosynthesis
MH  - Matrix Metalloproteinase 9/analysis/biosynthesis
MH  - Matrix Metalloproteinases/analysis/*biosynthesis
MH  - Myofibroblasts/*pathology
MH  - Precancerous Conditions/metabolism/*pathology
PMC - PMC4693555
OTO - NOTNLM
OT  - actinic cheilitis
OT  - cell proliferation
OT  - immunohistochemistry
OT  - lip cancer
OT  - matrix metalloproteinase-1
OT  - matrix metalloproteinase-2
OT  - matrix metalloproteinase-9
OT  - myofibroblasts
OT  - oral cancer
OT  - squamous cell carcinoma
EDAT- 2015/10/31 06:00
MHDA- 2016/05/24 06:00
PMCR- 2016/10/01
CRDT- 2015/10/31 06:00
PHST- 2015/05/27 00:00 [received]
PHST- 2015/07/18 00:00 [accepted]
PHST- 2015/10/31 06:00 [entrez]
PHST- 2015/10/31 06:00 [pubmed]
PHST- 2016/05/24 06:00 [medline]
PHST- 2016/10/01 00:00 [pmc-release]
AID - IEP12140 [pii]
AID - 10.1111/iep.12140 [doi]
PST - ppublish
SO  - Int J Exp Pathol. 2015 Oct;96(5):311-8. doi: 10.1111/iep.12140. Epub 2015 Oct 30.