PMID- 26515446 OWN - NLM STAT- MEDLINE DCOM- 20160913 LR - 20240109 IS - 1879-0712 (Electronic) IS - 0014-2999 (Linking) VI - 768 DP - 2015 Dec 5 TI - Fucosterol, a sterol extracted from Sargassum fusiforme, shows antidepressant and anticonvulsant effects. PG - 131-8 LID - S0014-2999(15)30322-8 [pii] LID - 10.1016/j.ejphar.2015.10.041 [doi] AB - We previously showed that extracts of Sargassum fusiforme significantly reduce immobility time in the forced swim test and tail suspension test, suggesting that these extracts possess antidepressant-like effects. Here, fucosterol extracted from S. fusiforme was evaluated for antidepressant and anticonvulsant activities in mice. Fucosterol (10, 20, 30 and 40mg/kg) significantly shortened immobility time in the forced swim test and tail suspension test for30min after treatment but had no effect on locomotor activity in the open field test. Fucosterol significantly increased serotonin, norepinephrine and the metabolite 5-hydroxyindoleacetic acid in mouse brain, suggesting that the effects of fucosterol may be mediated through these neurotransmitters. As assessed using maximal electroshock, fucosterol (20, 40, 100mg/kg) possessed anticonvulsant activity, whereas rotarod toxicity test results indicated that fucosterol did not induce neurotoxicity at the same dose levels in mice. Thus, fucosterol may be a useful antidepressant adjunct candidate for treating depression in patients with epilepsy. A significant increase in hippocampal brain-derived neurotrophic factor (BDNF) levels was found in the fucosterol 20mg/kg group (P<0.05). Our findings suggested that fucosterol may possess an antidepressant-like effect, which may be mediated by increasing central BDNF levels. CI - Copyright (c) 2015 Elsevier B.V. All rights reserved. FAU - Zhen, Xing-Hua AU - Zhen XH AD - Food and Pharmacy College, Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhejiang, Zhoushan 316022, China. FAU - Quan, Ying-Chun AU - Quan YC AD - Yanbian University School of Medicine, Jilin 133000, Yanji, China. FAU - Jiang, Hai-Ying AU - Jiang HY AD - Yanbian University School of Medicine, Jilin 133000, Yanji, China. FAU - Wen, Zheng-Shun AU - Wen ZS AD - Food and Pharmacy College, Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhejiang, Zhoushan 316022, China. FAU - Qu, You-Le AU - Qu YL AD - Food and Pharmacy College, Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhejiang, Zhoushan 316022, China. Electronic address: Youle1960@163.com. FAU - Guan, Li-Ping AU - Guan LP AD - Food and Pharmacy College, Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhejiang, Zhoushan 316022, China. Electronic address: glp730@163.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20151026 PL - Netherlands TA - Eur J Pharmacol JT - European journal of pharmacology JID - 1254354 RN - 0 (Anticonvulsants) RN - 0 (Antidepressive Agents) RN - 0 (Biogenic Monoamines) RN - 0 (Neurotransmitter Agents) RN - 504ZAM710C (fucosterol) RN - 99WUK5D0Y8 (Stigmasterol) SB - IM MH - Animals MH - Anticonvulsants/isolation & purification/*pharmacology/therapeutic use MH - Antidepressive Agents/isolation & purification/*pharmacology/therapeutic use MH - Biogenic Monoamines/metabolism MH - Brain/drug effects/metabolism MH - Depression/*drug therapy MH - Male MH - Mice MH - Mice, Inbred BALB C MH - Motor Activity/drug effects MH - Neurotransmitter Agents/metabolism MH - Sargassum/*chemistry MH - Seizures/*drug therapy MH - Stigmasterol/*analogs & derivatives/isolation & purification/pharmacology/therapeutic use MH - Swimming OTO - NOTNLM OT - Forced swim test OT - Fucosterol OT - Maximal electroshock seizure OT - Neuro-transmitters OT - Sargassum fusiforme OT - Tail suspension test EDAT- 2015/10/31 06:00 MHDA- 2016/09/14 06:00 CRDT- 2015/10/31 06:00 PHST- 2015/07/12 00:00 [received] PHST- 2015/10/16 00:00 [revised] PHST- 2015/10/23 00:00 [accepted] PHST- 2015/10/31 06:00 [entrez] PHST- 2015/10/31 06:00 [pubmed] PHST- 2016/09/14 06:00 [medline] AID - S0014-2999(15)30322-8 [pii] AID - 10.1016/j.ejphar.2015.10.041 [doi] PST - ppublish SO - Eur J Pharmacol. 2015 Dec 5;768:131-8. doi: 10.1016/j.ejphar.2015.10.041. Epub 2015 Oct 26.