PMID- 26516100
OWN - NLM
STAT- MEDLINE
DCOM- 20160922
LR  - 20151221
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 496
IP  - 2
DP  - 2015 Dec 30
TI  - Delivery of drugs to intracellular organelles using drug delivery systems: 
      Analysis of research trends and targeting efficiencies.
PG  - 268-74
LID - S0378-5173(15)30321-5 [pii]
LID - 10.1016/j.ijpharm.2015.10.053 [doi]
AB  - Targeting of drug delivery systems (DDSs) to specific intracellular organelles 
      (i.e., subcellular targeting) has been investigated in numerous publications, but 
      targeting efficiency of these systems is seldom reported. We searched scientific 
      publications in the subcellular DDS targeting field and analyzed targeting 
      efficiency and major formulation parameters that affect it. We identified 77 
      scientific publications that matched the search criteria. In the majority of 
      these studies nanoparticle-based DDSs were applied, while liposomes, quantum dots 
      and conjugates were used less frequently. The nucleus was the most common 
      intracellular target, followed by mitochondrion, endoplasmic reticulum and Golgi 
      apparatus. In 65% of the publications, DDSs surface was decorated with specific 
      targeting residues, but the efficiency of this surface decoration was not 
      analyzed in predominant majority of the studies. Moreover, only 23% of the 
      analyzed publications contained quantitative data on DDSs subcellular targeting 
      efficiency, while the majority of publications reported qualitative results only. 
      From the analysis of publications in the subcellular targeting field, it appears 
      that insufficient efforts are devoted to quantitative analysis of the major 
      formulation parameters and of the DDSs' intracellular fate. Based on these 
      findings, we provide recommendations for future studies in the field of 
      organelle-specific drug delivery and targeting.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Maity, Amit Ranjan
AU  - Maity AR
AD  - Department of Clinical Biochemistry and Pharmacology, The Faculty of Health 
      Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
FAU - Stepensky, David
AU  - Stepensky D
AD  - Department of Clinical Biochemistry and Pharmacology, The Faculty of Health 
      Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel. Electronic 
      address: davidst@bgu.ac.il.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151026
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Animals
MH  - Cell Nucleus/drug effects/metabolism
MH  - Drug Delivery Systems/*methods/trends
MH  - Endocytosis/drug effects/*physiology
MH  - Humans
MH  - Intracellular Fluid/drug effects/metabolism
MH  - Organelles/drug effects/*metabolism
MH  - Pharmaceutical Preparations/*administration & dosage/*metabolism
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Decoration with targeting residues
OT  - Drug delivery systems
OT  - Subcellular targeting
OT  - Targeted drug delivery
OT  - Targeting efficiency
EDAT- 2015/10/31 06:00
MHDA- 2016/09/23 06:00
CRDT- 2015/10/31 06:00
PHST- 2015/09/17 00:00 [received]
PHST- 2015/10/12 00:00 [revised]
PHST- 2015/10/19 00:00 [accepted]
PHST- 2015/10/31 06:00 [entrez]
PHST- 2015/10/31 06:00 [pubmed]
PHST- 2016/09/23 06:00 [medline]
AID - S0378-5173(15)30321-5 [pii]
AID - 10.1016/j.ijpharm.2015.10.053 [doi]
PST - ppublish
SO  - Int J Pharm. 2015 Dec 30;496(2):268-74. doi: 10.1016/j.ijpharm.2015.10.053. Epub 
      2015 Oct 26.