PMID- 26517617
OWN - NLM
STAT- MEDLINE
DCOM- 20160912
LR  - 20151031
IS  - 1943-569X (Electronic)
IS  - 0003-1488 (Linking)
VI  - 247
IP  - 10
DP  - 2015 Nov 15
TI  - Incidence rates and risk factors for owner-reported adverse events following 
      vaccination of dogs that did or did not receive a Leptospira vaccine.
PG  - 1139-45
LID - 10.2460/javma.247.10.1139 [doi]
AB  - OBJECTIVE: To determine incidence rates (IRs) and potential risk factors for 
      owner-reported adverse events (AEs) following vaccination of dogs that did or did 
      not receive a Leptospira vaccine. DESIGN: Observational, retrospective cohort 
      study. ANIMALS: 130,557 dogs. PROCEDURES: Electronic records of mobile veterinary 
      clinics from June 2012 to March 2013 were searched to identify dogs that received 
      >/= 1 vaccine in a given visit. Signalment data, vaccinations received, medications 
      administered, and owner-reported clinical signs consistent with AEs that 
      developed </= 5 days after vaccination were recorded. Associations between 
      potential risk factors and owner-reported AEs were evaluated by logistic 
      regression analysis. RESULTS: The IR/10,000 dogs for owner-reported 
      postvaccination AEs was 26.3 (95% CI, 23.6 to 29.2), whereas that for dogs that 
      received a Leptospira vaccine alone or with other vaccines was 53.0 (95% CI, 42.8 
      to 64.9). Significant factors for increasing or decreasing risk of AEs were as 
      follows: receiving a Leptospira vaccine (adjusted OR, 2.13), age at vaccination 1 
      to < 7 or >/= 7 years (vs a referent of < 6 months; adjusted OR, 0.54 and 0.44, 
      respectively), and weight 13.6 to < 22.7 kg (30 to < 50 lb) and 22.7 to < 45.5 kg 
      (50 to 100 lb [vs a referent of < 4.5 kg 10 lb]; adjusted OR, 0.48 and 0.55, 
      respectively). Hypersensitivity reactions were rare (IR, 6.5/10,000 dogs), and 
      IRs for these events did not differ significantly between dogs vaccinated with or 
      without a Leptospira component. CONCLUSIONS AND CLINICAL RELEVANCE: The overall 
      IR for owner-reported postvaccination AEs was low. Results suggested vaccination 
      against Leptospira (an organism that can cause fatal disease) is safe in the 
      majority of cases, slightly increasing the risk of owner-reported AEs but not 
      associated with a significant increase in hypersensitivity reactions, compared 
      with other vaccinations administered.
FAU - Yao, Peng Ju
AU  - Yao PJ
FAU - Stephenson, Nicole
AU  - Stephenson N
FAU - Foley, Janet E
AU  - Foley JE
FAU - Toussieng, Chuck R
AU  - Toussieng CR
FAU - Farver, Thomas B
AU  - Farver TB
FAU - Sykes, Jane E
AU  - Sykes JE
FAU - Fleer, Katryna A
AU  - Fleer KA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Vet Med Assoc
JT  - Journal of the American Veterinary Medical Association
JID - 7503067
RN  - 0 (Bacterial Vaccines)
SB  - IM
MH  - Animals
MH  - Bacterial Vaccines/administration & dosage/*adverse effects
MH  - Dog Diseases/*chemically induced/epidemiology
MH  - Dogs
MH  - Female
MH  - Leptospira/*immunology
MH  - Male
MH  - Odds Ratio
MH  - Retrospective Studies
MH  - Risk Factors
MH  - United States/epidemiology
EDAT- 2015/11/01 06:00
MHDA- 2016/09/13 06:00
CRDT- 2015/10/31 06:00
PHST- 2015/10/31 06:00 [entrez]
PHST- 2015/11/01 06:00 [pubmed]
PHST- 2016/09/13 06:00 [medline]
AID - 10.2460/javma.247.10.1139 [doi]
PST - ppublish
SO  - J Am Vet Med Assoc. 2015 Nov 15;247(10):1139-45. doi: 10.2460/javma.247.10.1139.