PMID- 26518023
OWN - NLM
STAT- MEDLINE
DCOM- 20160829
LR  - 20221207
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 233
IP  - 3
DP  - 2016 Feb
TI  - Effects of cigarette smoking and alcohol use on neurocognition and BDNF levels in 
      a Chinese population.
PG  - 435-45
LID - 10.1007/s00213-015-4124-6 [doi]
AB  - OBJECTIVE: Few studies have examined the potential interactive effect of both 
      smoking and drinking on cognition. Brain-derived neurotrophic factor (BDNF) plays 
      a critical role in cognition. This is the first study to examine the 
      neurocognitive consequences of cigarette smoking combined with chronic alcohol 
      consumption and their relationship to serum BDNF levels in a Chinese Han 
      population. MATERIALS AND METHODS: We recruited 191 healthy male subjects, 
      including 47 isolated smokers, 31 isolated chronic alcohol users, 58 combined 
      smokers and chronic alcohol users, and 55 non-smokers and non-alcohol users. We 
      then compared the repeatable battery for the assessment of neuropsychological 
      status (RBANS) scores and serum BDNF levels in these four groups. RESULTS: When 
      compared to the non-smoking + non-alcohol-using group, the smoking group 
      performed worse on immediate memory, attention, language, and RBANS total score. 
      There were no significant differences in the RBANS scores between the 
      alcohol-using group and non-smoking + non-alcohol-using group, or between the 
      smoking group and smoking + alcohol-using group. We did not find an association 
      between BDNF and smoking or drinking status or between BDNF and cognitive 
      performance. In the smoking group, there was a significant correlation between 
      BDNF and carbon monoxide concentration, and between BDNF and the Fagerstrom Test 
      for Nicotine Dependence (FTND) total score. CONCLUSIONS: Our results suggest that 
      smoking is associated with cognitive decline, but not with BDNF levels in a 
      normal population. However, smoking severity is positively associated with BDNF 
      levels. Concomitant alcohol use does not worsen the cognitive decline caused by 
      smoking.
FAU - Zhang, Xiang Yang
AU  - Zhang XY
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, China. 
      zhangxy9@gmail.com.
AD  - Department of Psychiatry and Behavioral Sciences, The University of Texas Health 
      Science Center at Houston, Houston, TX, USA. zhangxy9@gmail.com.
AD  - UT Center of Excellence on Mood Disorders (UTCEMD), Biomedical and Behavioral 
      Sciences Building, 1941 East Road, Houston, TX, 77054, USA. zhangxy9@gmail.com.
FAU - Tan, Yun-Long
AU  - Tan YL
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
FAU - Chen, Da-Chun
AU  - Chen DC
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
FAU - Tan, Shu-Ping
AU  - Tan SP
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
FAU - Yang, Fu-De
AU  - Yang FD
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
FAU - Zunta-Soares, Giovana B
AU  - Zunta-Soares GB
AD  - Department of Psychiatry and Behavioral Sciences, The University of Texas Health 
      Science Center at Houston, Houston, TX, USA.
FAU - Soares, Jair C
AU  - Soares JC
AD  - Department of Psychiatry and Behavioral Sciences, The University of Texas Health 
      Science Center at Houston, Houston, TX, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151030
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 7U1EE4V452 (Carbon Monoxide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alcohol Drinking/*metabolism/*psychology
MH  - Asian People
MH  - Attention/drug effects
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Carbon Monoxide/blood
MH  - China
MH  - Cognition/*drug effects
MH  - Humans
MH  - Language
MH  - Male
MH  - Memory/drug effects
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Psychomotor Performance/drug effects
MH  - Smoking/*metabolism/*psychology
MH  - Tobacco Use Disorder/psychology
MH  - Young Adult
OTO - NOTNLM
OT  - Alcohol
OT  - Brain-derived neurotrophic factor
OT  - Cognition
OT  - Nicotine
OT  - Smoking
EDAT- 2015/11/01 06:00
MHDA- 2016/08/30 06:00
CRDT- 2015/11/01 06:00
PHST- 2015/07/12 00:00 [received]
PHST- 2015/10/13 00:00 [accepted]
PHST- 2015/11/01 06:00 [entrez]
PHST- 2015/11/01 06:00 [pubmed]
PHST- 2016/08/30 06:00 [medline]
AID - 10.1007/s00213-015-4124-6 [pii]
AID - 10.1007/s00213-015-4124-6 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2016 Feb;233(3):435-45. doi: 
      10.1007/s00213-015-4124-6. Epub 2015 Oct 30.