PMID- 26518669
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20201026
IS  - 1878-3627 (Electronic)
IS  - 0922-6028 (Linking)
VI  - 34
IP  - 1
DP  - 2016
TI  - Delayed restraint procedure enhances cognitive recovery of spatial function 
      after fimbria-fornix transection.
PG  - 1-17
LID - 10.3233/RNN-140396 [doi]
AB  - PURPOSE: To i) evaluate the effect of a restraint procedure (7 days, 2 h/day) on 
      place learning after fimbria-fornix transection (FF), ii) investigate effects of 
      early vs. late administration of restraint, and iii) establish effects of the 
      restraint procedure on expression of brain derived neurotrophic factor (BDNF) in 
      prefrontal cortex and hippocampus. METHODS: Fifty rats subjected to FF or sham 
      surgery and divided into groups exposed to restraint immediately (early 
      restraint) or 21 days (late restraint) after surgery were trained to acquire an 
      allocentric place learning task. In parallel, 29 animals were subjected to FF or 
      sham surgery and an identical restraint procedure in order to measure 
      concentrations of BDNF and corticosterone. RESULTS: The performance of the sham 
      operated rats was positively affected by the late restraint. In FF-lesioned 
      animals, the late restraint significantly improved task performance compared to 
      the lesioned group with no restraint, while the early restraint was associated 
      with a negative impact on task acquisition. Biochemical analysis after restraint 
      procedure revealed a lesion-induced upregulation of BDNF in FF animals. 
      CONCLUSIONS: The improved task performance of lesioned animals suggests a 
      therapeutic effect of this manipulation, independent of BDNF. This effect is 
      sensitive to the temporal administration of treatment.
FAU - Gram, Marie Gajhede
AU  - Gram MG
AD  - The Unit for Cognitive Neuroscience, Department of Psychology, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Wogensen, Elise
AU  - Wogensen E
AD  - The Unit for Cognitive Neuroscience, Department of Psychology, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Wortwein, Gitta
AU  - Wortwein G
AD  - Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, 
      University of Copenhagen, Copenhagen, Denmark.
FAU - Mogensen, Jesper
AU  - Mogensen J
AD  - The Unit for Cognitive Neuroscience, Department of Psychology, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Mala, Hana
AU  - Mala H
AD  - The Unit for Cognitive Neuroscience, Department of Psychology, University of 
      Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Restor Neurol Neurosci
JT  - Restorative neurology and neuroscience
JID - 9005499
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Brain Diseases/metabolism/therapy
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition/physiology
MH  - Disease Models, Animal
MH  - Fornix, Brain/*physiopathology/surgery
MH  - Male
MH  - Maze Learning/*physiology
MH  - Neurosurgical Procedures
MH  - Prefrontal Cortex/*metabolism
MH  - Random Allocation
MH  - Rats, Wistar
MH  - Restraint, Physical/*methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Brain injury
OT  - functional recovery
OT  - rat
OT  - restraint procedure
OT  - time
EDAT- 2015/11/01 06:00
MHDA- 2016/10/07 06:00
CRDT- 2015/11/01 06:00
PHST- 2015/11/01 06:00 [entrez]
PHST- 2015/11/01 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
AID - RNN140396 [pii]
AID - 10.3233/RNN-140396 [doi]
PST - ppublish
SO  - Restor Neurol Neurosci. 2016;34(1):1-17. doi: 10.3233/RNN-140396.