PMID- 26520896
OWN - NLM
STAT- MEDLINE
DCOM- 20160914
LR  - 20151128
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 243
IP  - 2
DP  - 2015 Dec
TI  - IFN-gamma-producing Th17 cells bias by HMGB1-T-bet/RUNX3 axis might contribute to 
      progression of coronary artery atherosclerosis.
PG  - 421-8
LID - S0021-9150(15)30144-1 [pii]
LID - 10.1016/j.atherosclerosis.2015.09.037 [doi]
AB  - BACKGROUND: IFN-gamma-producing Th17 cells have been implicated in autoimmune 
      disorders, but their properties in humans are known only partially. The molecular 
      mechanisms and external factors that govern IFN-gamma-producing Th17-cell bias are 
      incompletely understood. The present work was to clarify whether (i) 
      IFN-gamma-producing Th17 cells are present in the peripheral circulation of patients 
      with coronary atherosclerosis (CA); (ii) high mobility group box (HMGB)1 in 
      circulation is associated with IFN-gamma-producing Th17-cell bias. METHODS: 
      Thirty-six patients (17 females and 19 males; 45-84 years) diagnosed as having 
      atherosclerosis after coronary angiography for suspected or known CA were 
      included the study cohort. Samples of peripheral blood were collected from 
      healthy volunteers and patients, and classical tests (flow cytometry, RT-qPCR) 
      were used to measure blood components. RESULTS AND CONCLUSION: Our results 
      clearly demonstrated that HMGB1 were up-regulated in different progressive CA 
      patients: 5.38 +/- 1.48 ng/ml, 6.30 +/- 1.53 ng/ml and 5.86 +/- 1.12 ng/ml 
      vs1.45 +/- 0.65 ng/ml for only atherosclerotic plaque (AP), atherosclerotic plaque 
      and some plaque rupture, no thrombosis (PR), plaque rupture and accompanying 
      thrombosis (TH) and volunteers, respectively, p < 0.05. The frequency of 
      IFN-gamma-producing Th17 cells was 2.33 +/- 0.58%, 1.93 +/- 0.2% and 2.21 +/- 0.65% vs 
      0.38 +/- 0.21% for AP, PR, TH and volunteers, p < 0.05, respectively. Furthermore, 
      HMGB1 contributed to IFN-gamma-producing Th17-cell bias by controlling expression of 
      T-bet and RUNX3. We demonstrated, for the first time, that HMGB1 is a potential 
      inducer of IFN-gamma-producing Th17-cell bias, and that IFN-gamma-producing Th17 cells 
      might be one of the pathogenic factors in atherosclerosis.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Su, Zhaoliang
AU  - Su Z
AD  - The Central Laboratory, the Fourth Affiliated Hospital of Jiangsu University, 
      Zhenjiang, 212001, China; Department of Immunology, School of Medicine, Jiangsu 
      University, Zhenjiang, 212013, China.
FAU - Lu, Hongxiang
AU  - Lu H
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      212013, China.
FAU - Jiang, Haiqiang
AU  - Jiang H
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      212013, China; Department of Laboratory Medicine, The Affiliated Jiangyin 
      Hospital of Nanjing University of Chinese Medicine, Jiangyin, 214400, China.
FAU - Zhu, Haitao
AU  - Zhu H
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      212013, China.
FAU - Li, Ze
AU  - Li Z
AD  - Department of Cardiology, The Fourth Hospital of Shanxi, Xi'an, 710043, China.
FAU - Zhang, Pan
AU  - Zhang P
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      212013, China.
FAU - Ni, Ping
AU  - Ni P
AD  - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 
      212013, China.
FAU - Shen, Huiling
AU  - Shen H
AD  - The Central Laboratory, the Fourth Affiliated Hospital of Jiangsu University, 
      Zhenjiang, 212001, China.
FAU - Xu, Wenlin
AU  - Xu W
AD  - The Central Laboratory, the Fourth Affiliated Hospital of Jiangsu University, 
      Zhenjiang, 212001, China.
FAU - Xu, Huaxi
AU  - Xu H
AD  - The Central Laboratory, the Fourth Affiliated Hospital of Jiangsu University, 
      Zhenjiang, 212001, China. Electronic address: szl30@yeah.net.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151003
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Core Binding Factor Alpha 3 Subunit)
RN  - 0 (HMGB1 Protein)
RN  - 0 (HMGB1 protein, human)
RN  - 0 (IFNG protein, human)
RN  - 0 (Runx3 protein, human)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (T-box transcription factor TBX21)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Cells, Cultured
MH  - Core Binding Factor Alpha 3 Subunit/genetics/*metabolism
MH  - Coronary Artery Disease/blood/diagnosis/genetics/immunology/*metabolism
MH  - Coronary Thrombosis/blood/diagnosis/genetics/immunology/*metabolism
MH  - Disease Progression
MH  - Female
MH  - HMGB1 Protein/blood/genetics/*metabolism
MH  - Humans
MH  - Interferon-gamma/blood/genetics/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Plaque, Atherosclerotic
MH  - RNA Interference
MH  - Rupture, Spontaneous
MH  - Severity of Illness Index
MH  - Signal Transduction
MH  - T-Box Domain Proteins/genetics/*metabolism
MH  - Th17 Cells/immunology/*metabolism
MH  - Transfection
OTO - NOTNLM
OT  - Atherosclerosis
OT  - HMGB1
OT  - IFN-gamma-producing Th17
EDAT- 2015/11/02 06:00
MHDA- 2016/09/15 06:00
CRDT- 2015/11/02 06:00
PHST- 2015/04/09 00:00 [received]
PHST- 2015/09/28 00:00 [revised]
PHST- 2015/09/29 00:00 [accepted]
PHST- 2015/11/02 06:00 [entrez]
PHST- 2015/11/02 06:00 [pubmed]
PHST- 2016/09/15 06:00 [medline]
AID - S0021-9150(15)30144-1 [pii]
AID - 10.1016/j.atherosclerosis.2015.09.037 [doi]
PST - ppublish
SO  - Atherosclerosis. 2015 Dec;243(2):421-8. doi: 
      10.1016/j.atherosclerosis.2015.09.037. Epub 2015 Oct 3.