PMID- 26520916
OWN - NLM
STAT- MEDLINE
DCOM- 20160516
LR  - 20201124
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Linking)
VI  - 168
DP  - 2016 Jan
TI  - Factors Associated with Respiratory Illness in Children and Young Adults with 
      Cerebral Palsy.
PG  - 151-157.e1
LID - S0022-3476(15)01138-5 [pii]
LID - 10.1016/j.jpeds.2015.09.064 [doi]
AB  - OBJECTIVE: To describe associations between respiratory illness and its potential 
      predictors in children and young adults with cerebral palsy (CP). STUDY DESIGN: 
      Cross-sectional survey of self- and caregiver-reported respiratory symptoms for 
      individuals aged up to 26 years with CP. Respiratory illness was indicated by 2 
      outcomes: (1) >/=1 respiratory hospitalizations in the past year; and (2) >/=2 
      courses of antibiotics for respiratory symptoms in the past year. ORs were 
      calculated using univariate and multivariate logistic regression. RESULTS: There 
      were 551 participants, aged 1-26 years, distributed across all gross motor 
      function classification scale (GMFCS) levels. In univariate analyses, factors 
      significantly associated with respiratory hospitalizations were weekly 
      respiratory symptoms (OR 2.31, 95% CI 1.78-3.00), respiratory symptoms during 
      meals (OR 3.23, 95% CI 1.50-5.80), gastroesophageal reflux (OR 3.01, 95% CI 
      1.71-5.31), coughing or choking on saliva (OR 4.36, 95% CI 2.38-8.01), current 
      asthma (OR 3.56, 95% CI 1.97-6.42), age (0-3 years) (OR 3.24, 95% CI 1.19-8.80, 
      compared with 13-17 years), seizures (OR 3.45, 95% CI 1.96-6.08), and scoliosis 
      (OR 2.14, 95% CI 1.16-3.97). Nonambulatory individuals (GMFCS IV-V) were at 
      significantly increased risk of hospitalizations only if they had food 
      modifications and/or nasogastric or gastrostomy tube feeds (OR 5.36, 95% CI 
      2.89-9.96, compared with GMFCS I-III with no food modifications and no tube). All 
      factors, except seizures and scoliosis, were significantly associated with 
      multiple courses of antibiotics in univariate analyses. CONCLUSIONS: Oromotor 
      dysfunction is strongly associated with respiratory illness in patients with CP.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Blackmore, Amanda Marie
AU  - Blackmore AM
AD  - Therapy and Health Services, Ability Centre, Mount Lawley, Western Australia, 
      Australia. Electronic address: marie.blackmore@abilitycentre.com.au.
FAU - Bear, Natasha
AU  - Bear N
AD  - Physiotherapy, Princess Margaret Hospital for Children, Subiaco, Western 
      Australia, Australia; Telethon Kids Institute, The University of Western 
      Australia, Subiaco, Western Australia, Australia; Pediatric Rehabilitation, 
      Princess Margaret Hospital for Children, Subiaco, Western Australia, Australia.
FAU - Blair, Eve
AU  - Blair E
AD  - Telethon Kids Institute, The University of Western Australia, Subiaco, Western 
      Australia, Australia.
FAU - Gibson, Noula
AU  - Gibson N
AD  - Therapy and Health Services, Ability Centre, Mount Lawley, Western Australia, 
      Australia; Physiotherapy, Princess Margaret Hospital for Children, Subiaco, 
      Western Australia, Australia.
FAU - Jalla, Caris
AU  - Jalla C
AD  - Therapy and Health Services, Ability Centre, Mount Lawley, Western Australia, 
      Australia.
FAU - Langdon, Katherine
AU  - Langdon K
AD  - Pediatric Rehabilitation, Princess Margaret Hospital for Children, Subiaco, 
      Western Australia, Australia.
FAU - Moshovis, Lisa
AU  - Moshovis L
AD  - Therapy and Health Services, Ability Centre, Mount Lawley, Western Australia, 
      Australia.
FAU - Steer, Kellie
AU  - Steer K
AD  - Perth Children's Hospital Project, Princess Margaret Hospital for Children, 
      Subiaco, Western Australia, Australia.
FAU - Wilson, Andrew C
AU  - Wilson AC
AD  - Telethon Kids Institute, The University of Western Australia, Subiaco, Western 
      Australia, Australia; Respiratory Medicine, Princess Margaret Hospital for 
      Children, Subiaco, Western Australia, Australia; School of Paediatrics and Child 
      Health, The University of Western Australia, Crawley, Western Australia, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151029
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cerebral Palsy/*complications
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Prognosis
MH  - Respiration Disorders/*etiology
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2015/11/02 06:00
MHDA- 2016/05/18 06:00
CRDT- 2015/11/02 06:00
PHST- 2015/06/09 00:00 [received]
PHST- 2015/08/27 00:00 [revised]
PHST- 2015/09/24 00:00 [accepted]
PHST- 2015/11/02 06:00 [entrez]
PHST- 2015/11/02 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
AID - S0022-3476(15)01138-5 [pii]
AID - 10.1016/j.jpeds.2015.09.064 [doi]
PST - ppublish
SO  - J Pediatr. 2016 Jan;168:151-157.e1. doi: 10.1016/j.jpeds.2015.09.064. Epub 2015 
      Oct 29.