PMID- 26521824
OWN - NLM
STAT- MEDLINE
DCOM- 20160822
LR  - 20191210
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 38
IP  - 11
DP  - 2015
TI  - Investigation of Antiulcer and Antioxidant Activity of Juniperus phoenicea L. 
      (1753) Essential Oil in an Experimental Rat Model.
PG  - 1738-46
LID - 10.1248/bpb.b15-00412 [doi]
AB  - Juniperus phoenicea is a tree of the Cupressaceae family that is popularly known 
      in the south of Tunisia because of its wide application in herbal medicine, 
      including the use of its leaves to treat many diseases such as diarrhea, 
      rheumatism, and intestinal disorders. The aim of this study was to evaluate the 
      ulceroprotective and antioxidant activity of essential oil extracted from the 
      leaves of J. phoenicea (EOJp) against hydrogen chloride (HCl)/ethanol-induced 
      ulcers in rats. The antiulcer activities of 50, 75 and 100 mg/kg body weight 
      (b.w.) EOJp were investigated on 0.3 M HCl/ethanol-induced ulcers in rats. The 
      essential oil yield was 0.69% with 48 compounds; alpha-pinene was the principal 
      component (20.24%). In vivo pretreatment with EOJp given orally provided 
      dose-dependent protection against HCl/ethanol-induced gastric ulcers in rats. 
      Furthermore, pretreatment with EOJp significantly decreased malondialdehyde (MDA) 
      content and increased the activities of superoxide dismutase (SOD), catalase 
      (CAT) and glutathione peroxidase (GPx). The activity of the antiulcerogenic EOJp 
      could be from synergistic antioxidant and anti-secretory effects. Oral use of 
      EOJp has excellent preventive effects on induced gastric ulcers comparable to 
      those of the proton pump inhibitor (PPI) omeprazole.
FAU - Ben Ali, Manel Jemasmall yi, Ukrainian
AU  - Ben Ali MJ
AD  - Laboratory of Environment Biomonitoring (LR01/ES14), Faculty of Sciences of 
      Bizerte, University of Carthage.
FAU - Guesmi, Fatma
AU  - Guesmi F
FAU - Harrath, Abdel Halim
AU  - Harrath AH
FAU - Alwasel, Saleh
AU  - Alwasel S
FAU - Hedfi, Amor
AU  - Hedfi A
FAU - Ncib, Sana
AU  - Ncib S
FAU - Landoulsi, Ahmed
AU  - Landoulsi A
FAU - Aldahmash, Badr
AU  - Aldahmash B
FAU - Ben-Attia, Mossadok
AU  - Ben-Attia M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Bicyclic Monoterpenes)
RN  - 0 (Monoterpenes)
RN  - 0 (Oils, Volatile)
RN  - 0 (Plant Extracts)
RN  - 3K9958V90M (Ethanol)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - JPF3YI7O34 (alpha-pinene)
RN  - QTT17582CB (Hydrochloric Acid)
SB  - IM
MH  - Animals
MH  - Anti-Ulcer Agents/pharmacology/*therapeutic use
MH  - Antioxidants/metabolism/pharmacology/*therapeutic use
MH  - Bicyclic Monoterpenes
MH  - Catalase/metabolism
MH  - Disease Models, Animal
MH  - Ethanol
MH  - Glutathione Peroxidase/metabolism
MH  - Hydrochloric Acid
MH  - Juniperus/*chemistry
MH  - Male
MH  - Malondialdehyde/blood
MH  - Monoterpenes/pharmacology/therapeutic use
MH  - Oils, Volatile/chemistry/pharmacology/*therapeutic use
MH  - *Phytotherapy
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - Rats, Wistar
MH  - Stomach Ulcer/chemically induced/*drug therapy/metabolism
MH  - Superoxide Dismutase/metabolism
EDAT- 2015/11/03 06:00
MHDA- 2016/08/23 06:00
CRDT- 2015/11/03 06:00
PHST- 2015/11/03 06:00 [entrez]
PHST- 2015/11/03 06:00 [pubmed]
PHST- 2016/08/23 06:00 [medline]
AID - 10.1248/bpb.b15-00412 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2015;38(11):1738-46. doi: 10.1248/bpb.b15-00412.