PMID- 26522065
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160120
LR  - 20151102
IS  - 1165-158X (Electronic)
IS  - 0145-5680 (Linking)
VI  - 61
IP  - 5
DP  - 2015 Oct 30
TI  - Effect of Tongxinluo on nerve regeneration in mice with diabetic peripheral 
      neuropathy.
PG  - 103-7
AB  - Diabetic peripheral neuropathy (DPN) is a common complication of diabetes. This 
      study aims to investigate the effects of Tongxinluo on the nerve regeneration in 
      diabetic peripheral neuropathy mice. Forty Specefic Pathogen Free (SPF) male 
      KK/Upj—Ay mice were divided into diabetes group, diabetes with high dose 
      Tongxinluo (4g/kg) (D+H), diabetes with mid dose Tongxinluo (2g/kg) (D+M), and 
      diabetes with low dose Tongxinluo (1g/kg) (D+L) groups. Fasting blood glucose 
      (FPG), heat pain threshold, motor nerve conduction velocity (MNCV), 
      insulin—like growth factor—1 (IGF1), activator protein 1 
      (c—fos), nerve growth factor (NGF), and basic fibroblast growth factor 
      (BFGF) were measured. Results indicated that FPG of diabetes group was 
      significantly higher than that of control group. Heat pain threshold and MNCV 
      were significantly lowered in diabetes group. Expression levels of IGF1, NGF and 
      BFGF were significantly lower than that of control, whereas c—fos 
      expression was significantly higher than that of control group. Tongxinluo 
      treatment (D+M and D+H) significantly up—regulated heat pain threshold, 
      MNCV, and IGF1, NGF and BFGF expression, but decreased c—fos expresson when 
      compared to that of diabetes group. In conclusion, Tongxinluo can ameliorate 
      diabetic peripheral neuropathy, improve MNCV, and promote nerve regeneration. The 
      underlying mechanism needs to be further elucidated.
FAU - Li, X
AU  - Li X
AD  - Henan Provincial People's Hospital Department of Neurology Zhengzhou China 
      lixuehn@yeah.net.
FAU - Zhang, J
AU  - Zhang J
AD  - Henan Provincial People's Hospital Department of Neurology Zhengzhou China.
FAU - Zhao, W
AU  - Zhao W
AD  - Zhengzhou Maternal and Child Health Hospital Department of Pharmacology Zhengzhou 
      China.
FAU - Yang, H
AU  - Yang H
AD  - Henan Provincial People's Hospital Department of Neurology Zhengzhou China.
FAU - Ma, J
AU  - Ma J
AD  - Henan Provincial People's Hospital Department of Neurology Zhengzhou China.
FAU - Qi, Y
AU  - Qi Y
AD  - Henan Provincial People's Hospital Department of Neurology Zhengzhou China.
FAU - Wu, S
AU  - Wu S
AD  - Henan Provincial People's Hospital Department of Neurology Zhengzhou China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20151030
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RIN - Cell Mol Biol (Noisy-le-grand). 2015;61(5):103-7. PMID: 26690972
EDAT- 2015/11/03 06:00
MHDA- 2015/11/03 06:01
CRDT- 2015/11/03 06:00
PHST- 2015/08/20 00:00 [received]
PHST- 2015/10/23 00:00 [accepted]
PHST- 2015/11/03 06:00 [entrez]
PHST- 2015/11/03 06:00 [pubmed]
PHST- 2015/11/03 06:01 [medline]
PST - epublish
SO  - Cell Mol Biol (Noisy-le-grand). 2015 Oct 30;61(5):103-7.