PMID- 26522247
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20161230
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 82
DP  - 2016 Jan
TI  - Anti-tumor and immunomodulatory activity of selenium (Se)-polysaccharide from 
      Se-enriched Grifola frondosa.
PG  - 607-13
LID - S0141-8130(15)30084-2 [pii]
LID - 10.1016/j.ijbiomac.2015.10.083 [doi]
AB  - A polysaccharide termed Se-GP11 was extracted and purified from Se-enriched 
      Grifola frondosa in our previous study. This study investigated the 
      characterization, anti-tumor and immunomodulatory activity of Se-GP11. The 
      results showed that Se-GP11 was composed of mannose, glucose and galactose with a 
      molar ratio of 1:4.91:2.41. The weight-average molecular weight (Mw) and 
      weight-average mean square radius (Rw) of Se-GP11 in 0.1M sodium chloride 
      solution were 3.3x10(4)Da and 32.8 nm. Se-GP11 existed as a globular conformation 
      with random coil structure. Se-GP11 had no anti-tumor activity against HepG-2 
      cells in vitro, and it significantly inhibited the growth of Heps tumor in vivo. 
      Se-GP11 increased the relatively thymus and spleen weights as well as serum 
      necrosis factor-alpha (TNF-alpha) and interleukin-2 (IL-2) levels. In addition, 
      Se-GP11 promoted the phagocytosis and NO production of RAW264.7 as compared with 
      that of the normal control group. The results revealed that the Se-GP11 may 
      exhibit the anti-tumor through improving immunologic function of the tumor 
      bearing mice.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Mao, Guang-Hua
AU  - Mao GH
AD  - School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu, 
      Rd., 212013 Zhenjiang, Jiangsu, China.
FAU - Ren, Yi
AU  - Ren Y
AD  - School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Rd., 
      212013 Zhenjiang, Jiangsu, China.
FAU - Li, Qian
AU  - Li Q
AD  - School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Rd., 
      212013 Zhenjiang, Jiangsu, China.
FAU - Wu, Hui-Yu
AU  - Wu HY
AD  - School of Pharmacy, Jiangsu University, 301 Xuefu Rd., 212013 Zhenjiang, Jiangsu, 
      China.
FAU - Jin, Dun
AU  - Jin D
AD  - School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Rd., 
      212013 Zhenjiang, Jiangsu, China.
FAU - Zhao, Ting
AU  - Zhao T
AD  - School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Rd., 
      212013 Zhenjiang, Jiangsu, China.
FAU - Xu, Cai-Quan
AU  - Xu CQ
AD  - Zhejiang Fangge Pharmaceutical Co., Ltd., Xingguang Rd., 323800 Qingyuan, 
      Zhejiang, China.
FAU - Zhang, Deng-Hong
AU  - Zhang DH
AD  - School of Pharmacy, Jiangsu University, 301 Xuefu Rd., 212013 Zhenjiang, Jiangsu, 
      China.
FAU - Jia, Qing-Dong
AU  - Jia QD
AD  - School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Rd., 
      212013 Zhenjiang, Jiangsu, China.
FAU - Bai, Yan-Peng
AU  - Bai YP
AD  - School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Rd., 
      212013 Zhenjiang, Jiangsu, China.
FAU - Yang, Liu-Qing
AU  - Yang LQ
AD  - School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Rd., 
      212013 Zhenjiang, Jiangsu, China. Electronic address: yangliuqing@ujs.edu.cn.
FAU - Wu, Xiang-Yang
AU  - Wu XY
AD  - School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu, 
      Rd., 212013 Zhenjiang, Jiangsu, China. Electronic address: wuxy@ujs.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151030
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Fungal Polysaccharides)
RN  - 0 (Immunologic Factors)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*chemistry/*pharmacology
MH  - Biomarkers
MH  - Cell Line, Tumor
MH  - Disease Models, Animal
MH  - Female
MH  - Fungal Polysaccharides/*chemistry/*pharmacology
MH  - Grifola/*chemistry
MH  - Humans
MH  - Immunologic Factors/*chemistry/*pharmacology
MH  - Macrophage Activation/drug effects
MH  - Macrophages/drug effects/immunology/metabolism
MH  - Mice
MH  - Selenium/*chemistry
MH  - Xenograft Model Antitumor Assays
OTO - NOTNLM
OT  - Anti-tumor
OT  - Characterization
OT  - Immunomodulatory
OT  - Polysaccharide
OT  - Se-enriched Grifola frondosa
EDAT- 2015/11/03 06:00
MHDA- 2016/10/14 06:00
CRDT- 2015/11/03 06:00
PHST- 2015/07/23 00:00 [received]
PHST- 2015/10/26 00:00 [revised]
PHST- 2015/10/27 00:00 [accepted]
PHST- 2015/11/03 06:00 [entrez]
PHST- 2015/11/03 06:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
AID - S0141-8130(15)30084-2 [pii]
AID - 10.1016/j.ijbiomac.2015.10.083 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2016 Jan;82:607-13. doi: 10.1016/j.ijbiomac.2015.10.083. 
      Epub 2015 Oct 30.