PMID- 26522940
OWN - NLM
STAT- MEDLINE
DCOM- 20160622
LR  - 20171024
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 127
IP  - 2
DP  - 2016 Feb
TI  - Ipsilateral cortical motor desynchronisation is reduced in Benign Epilepsy with 
      Centro-Temporal Spikes.
PG  - 1147-1156
LID - S1388-2457(15)00955-4 [pii]
LID - 10.1016/j.clinph.2015.08.020 [doi]
AB  - OBJECTIVE: Magnetoencephalography (MEG) and a simple motor paradigm were used to 
      study induced sensorimotor responses and their relationship to motor skills in 
      children diagnosed with Benign Epilepsy with Centro-Temporal Spikes (BECTS). 
      METHODS: Twenty-one children with BECTS and 15 age-matched controls completed a 
      finger abduction task in MEG; movement-related oscillatory responses were derived 
      and contrasted between groups. A subset of children also completed 
      psycho-behavioural assessments. Regression analyses explored the relationship of 
      MEG responses to manual dexterity performance, and dependence upon clinical 
      characteristics. RESULTS: In children with BECTS, manual dexterity was below the 
      population mean (p=.002) and three showed severe impairment. Our main significant 
      finding was of reduced ipsilateral movement related beta desynchrony (MRBDi) in 
      BECTS relative to the control group (p=.03) and predicted by epileptic seizure 
      recency (p=.02), but not age, medication status, or duration of epilepsy. 
      Laterality scores across the entire cohort indicated that less lateralised MRBD 
      predicted better manual dexterity (p=.04). CONCLUSIONS: Altered movement-related 
      oscillatory responses in ipsilateral motor cortex were associated with motor 
      skill deficits in children with BECTS. These changes were more marked in those 
      with more recent seizures. SIGNIFICANCE: These findings may reflect differences 
      in inter-hemispheric interactions during motor control in BECTS.
CI  - Copyright (c) 2015 International Federation of Clinical Neurophysiology. Published 
      by Elsevier Ireland Ltd. All rights reserved.
FAU - Brindley, Lisa M
AU  - Brindley LM
AD  - Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, 
      UK. Electronic address: lisabrindley78@gmail.com.
FAU - Koelewijn, Loes
AU  - Koelewijn L
AD  - Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, 
      UK.
FAU - Kirby, Amanda
AU  - Kirby A
AD  - Dyscovery Centre, University of South Wales, Newport, UK.
FAU - Williams, Natalie
AU  - Williams N
AD  - Dyscovery Centre, University of South Wales, Newport, UK.
FAU - Thomas, Marie
AU  - Thomas M
AD  - Dyscovery Centre, University of South Wales, Newport, UK.
FAU - Te Water-Naude, Johann
AU  - Te Water-Naude J
AD  - Department of Child Health, University Hospital of Wales, Cardiff, UK.
FAU - Gibbon, Frances
AU  - Gibbon F
AD  - Department of Child Health, University Hospital of Wales, Cardiff, UK.
FAU - Muthukumaraswamy, Suresh
AU  - Muthukumaraswamy S
AD  - Schools of Pharmacy and Psychology, University of Auckland, Auckland, New 
      Zealand.
FAU - Singh, Krish D
AU  - Singh KD
AD  - Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, 
      UK.
FAU - Hamandi, Khalid
AU  - Hamandi K
AD  - Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, 
      UK; Welsh Epilepsy Centre, University Hospital of Wales, Cardiff, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151014
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
CIN - Clin Neurophysiol. 2016 Feb;127(2):991-2. PMID: 26525364
MH  - Action Potentials/physiology
MH  - Adolescent
MH  - Brain Waves/*physiology
MH  - Child
MH  - Cohort Studies
MH  - Cortical Synchronization/*physiology
MH  - Epilepsy, Rolandic/*diagnosis/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetoencephalography/*methods
MH  - Male
MH  - Motor Cortex/*physiopathology
OTO - NOTNLM
OT  - BECTS
OT  - Development
OT  - MEG
OT  - Movement
OT  - Oscillations
EDAT- 2015/11/03 06:00
MHDA- 2016/06/23 06:00
CRDT- 2015/11/03 06:00
PHST- 2014/12/12 00:00 [received]
PHST- 2015/08/09 00:00 [revised]
PHST- 2015/08/17 00:00 [accepted]
PHST- 2015/11/03 06:00 [entrez]
PHST- 2015/11/03 06:00 [pubmed]
PHST- 2016/06/23 06:00 [medline]
AID - S1388-2457(15)00955-4 [pii]
AID - 10.1016/j.clinph.2015.08.020 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2016 Feb;127(2):1147-1156. doi: 10.1016/j.clinph.2015.08.020. 
      Epub 2015 Oct 14.