PMID- 26523792
OWN - NLM
STAT- MEDLINE
DCOM- 20160509
LR  - 20151228
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 610
DP  - 2016 Jan 1
TI  - Estrogen receptor-mediated effect of delta-tocotrienol prevents neurotoxicity and 
      motor deficit in the MPTP mouse model of Parkinson's disease.
PG  - 117-22
LID - S0304-3940(15)30225-1 [pii]
LID - 10.1016/j.neulet.2015.10.062 [doi]
AB  - Neuroprotection following signal transduction has been investigated recently as a 
      strategy for Parkinson's disease (PD) therapy. While oxidative stress is 
      important in the pathogenesis of PD, neuroprotection using antioxidants such as 
      alpha-tocopherol have not been successful. delta-tocotrienol (deltaT3), a member of the 
      vitamin E family, has received attention because of activities other than its 
      antioxidative effects. In the present study, we examined the estrogen receptor-beta 
      (ERbeta)-mediated neuroprotective effects of deltaT3 in a mouse model of PD. ERbeta is 
      expressed in neuronal cells, including dopaminergic neurons in the substantia 
      nigra. Daily forced oral administration of deltaT3 inhibited the loss of dopaminergic 
      neurons in the substantia nigra. In addition, the ER inhibitor tamoxifen canceled 
      the neuroprotective effects of deltaT3. Moreover, deltaT3 administration improved the 
      performance of the PD mice in the wheel running activity, while tamoxifen 
      inhibited this improved performance. These results suggest that the oral 
      administration of deltaT3 may be useful in the treatment of PD patients, and ERbeta may 
      be a candidate target for the neuroprotection activity of deltaT3.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Nakaso, Kazuhiro
AU  - Nakaso K
AD  - Division of Medical Biochemistry, Department of Pathophysiological and 
      Therapeutic Science, Tottori University Faculty of Medicine, Japan. Electronic 
      address: kazuhiro@med.tottori-u.ac.jp.
FAU - Horikoshi, Yosuke
AU  - Horikoshi Y
AD  - Division of Medical Biochemistry, Department of Pathophysiological and 
      Therapeutic Science, Tottori University Faculty of Medicine, Japan.
FAU - Takahashi, Toru
AU  - Takahashi T
AD  - Division of Medical Biochemistry, Department of Pathophysiological and 
      Therapeutic Science, Tottori University Faculty of Medicine, Japan.
FAU - Hanaki, Takehiko
AU  - Hanaki T
AD  - Division of Medical Biochemistry, Department of Pathophysiological and 
      Therapeutic Science, Tottori University Faculty of Medicine, Japan; Division of 
      Surgical Oncology, Department of Surgery, Tottori University Faculty of Medicine, 
      Japan.
FAU - Nakasone, Masato
AU  - Nakasone M
AD  - Division of Anesthesiology and Clinical Care Medicine, Department of Surgery, 
      Tottori University Faculty of Medicine, Japan.
FAU - Kitagawa, Yoshinori
AU  - Kitagawa Y
AD  - Division of Anesthesiology and Clinical Care Medicine, Department of Surgery, 
      Tottori University Faculty of Medicine, Japan.
FAU - Koike, Taisuke
AU  - Koike T
AD  - Planning & Development Department, Eisai Food & Chemical Co., Ltd., Japan.
FAU - Matsura, Tatsuya
AU  - Matsura T
AD  - Division of Medical Biochemistry, Department of Pathophysiological and 
      Therapeutic Science, Tottori University Faculty of Medicine, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151030
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Neuroprotective Agents)
RN  - 1406-18-4 (Vitamin E)
RN  - 1SRB74OWSI (tocotrienol, delta)
RN  - R865A5OY8J (1-Methyl-4-phenylpyridinium)
SB  - IM
MH  - *1-Methyl-4-phenylpyridinium
MH  - Animals
MH  - Estrogen Receptor alpha/metabolism
MH  - Estrogen Receptor beta/*metabolism
MH  - Female
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Motor Skills
MH  - Neuroprotective Agents/*therapeutic use
MH  - Parkinson Disease/*drug therapy/etiology/physiopathology
MH  - Vitamin E/*analogs & derivatives/therapeutic use
OTO - NOTNLM
OT  - Estrogen receptor
OT  - MPTP
OT  - Parkinson's disease
OT  - Tocotrienol
OT  - Vitamin E
EDAT- 2015/11/03 06:00
MHDA- 2016/05/10 06:00
CRDT- 2015/11/03 06:00
PHST- 2015/09/16 00:00 [received]
PHST- 2015/10/20 00:00 [revised]
PHST- 2015/10/24 00:00 [accepted]
PHST- 2015/11/03 06:00 [entrez]
PHST- 2015/11/03 06:00 [pubmed]
PHST- 2016/05/10 06:00 [medline]
AID - S0304-3940(15)30225-1 [pii]
AID - 10.1016/j.neulet.2015.10.062 [doi]
PST - ppublish
SO  - Neurosci Lett. 2016 Jan 1;610:117-22. doi: 10.1016/j.neulet.2015.10.062. Epub 
      2015 Oct 30.