PMID- 26523976
OWN - NLM
STAT- MEDLINE
DCOM- 20161007
LR  - 20161230
IS  - 1466-1799 (Electronic)
IS  - 0007-1668 (Linking)
VI  - 56
IP  - 6
DP  - 2015
TI  - Three indel variants in chicken LPIN1 exon 6/flanking region are associated with 
      performance and carcass traits.
PG  - 621-30
LID - 10.1080/00071668.2015.1113502 [doi]
AB  - LPIN1 is a Mg(2+)-dependent phosphatidic acid phosphatase. Variation in chicken 
      LPIN1 exon 6 and its flanking regions were identified and three indel variants in 
      6 breeds and their associations with performance traits were studied. Seven 
      variants were detected from 6 breeds, which contained a synonymous tri-allelic 
      variant (c.924A/T/C) and three indels. The exon 6 variants detected from chicken 
      breeds were conserved among bird species. The indel variation frequency presented 
      clear differences among breeds. Two coding indels (c.1014-1018del3 and 
      c.1125-1138del12) were multiples of three nucleotides and maintained the open 
      reading frames of LPIN1 proteins. However, they were predicted to result in the 
      clear change of the RNA secondary structure of chicken LPIN1 exon 6 and LPIN1 
      protein conformation. The association analysis showed that c.871-15-22del6 
      variation had a significant effect on body weight at hatch (BW0) and 2 weeks 
      (BW2); c. 1014-1018del3 variation had a significant effect on BW4, BW6, caecum 
      length and gizzard weight (GW) traits; c.1125-1138del12 variation had a 
      significant effect on BW12, shank length at 4 weeks (SL4), carcass weight, 
      lactate dehydrogenase traits (LDH), glucose (GLU) and albumin (ALB) traits. The 
      genotype combination for c.1014-1018del3 and c.1125-1138del12 also presented 
      significant effects on SL4, SL8, GW, leg muscle weight, ALB, GLU and LDH. The 
      study demonstrated that chicken LPIN1 has an important effect on body, carcass 
      and organ weight, serum LDH, GLU and ALB level.
FAU - Wang, R
AU  - Wang R
AD  - a College of Livestock Husbandry and Veterinary Engineering , Henan Agricultural 
      University , Zhengzhou , Henan , P. R. China.
FAU - Wang, T
AU  - Wang T
AD  - a College of Livestock Husbandry and Veterinary Engineering , Henan Agricultural 
      University , Zhengzhou , Henan , P. R. China.
FAU - Lu, W
AU  - Lu W
AD  - a College of Livestock Husbandry and Veterinary Engineering , Henan Agricultural 
      University , Zhengzhou , Henan , P. R. China.
FAU - Zhang, W
AU  - Zhang W
AD  - a College of Livestock Husbandry and Veterinary Engineering , Henan Agricultural 
      University , Zhengzhou , Henan , P. R. China.
FAU - Chen, W
AU  - Chen W
AD  - a College of Livestock Husbandry and Veterinary Engineering , Henan Agricultural 
      University , Zhengzhou , Henan , P. R. China.
FAU - Kang, X
AU  - Kang X
AD  - a College of Livestock Husbandry and Veterinary Engineering , Henan Agricultural 
      University , Zhengzhou , Henan , P. R. China.
FAU - Huang, Y
AU  - Huang Y
AD  - a College of Livestock Husbandry and Veterinary Engineering , Henan Agricultural 
      University , Zhengzhou , Henan , P. R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br Poult Sci
JT  - British poultry science
JID - 15740290R
RN  - 0 (Avian Proteins)
RN  - 0 (Blood Glucose)
RN  - 0 (Serum Albumin)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 3.1.3.4 (Phosphatidate Phosphatase)
SB  - IM
MH  - Animals
MH  - Avian Proteins/*genetics/metabolism
MH  - Blood Glucose/metabolism
MH  - Body Weight/genetics
MH  - Chickens/genetics/*physiology
MH  - Exons
MH  - *Genetic Association Studies
MH  - *INDEL Mutation
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Organ Size/genetics
MH  - Phosphatidate Phosphatase/*genetics/metabolism
MH  - Serum Albumin/metabolism
EDAT- 2015/11/03 06:00
MHDA- 2016/10/08 06:00
CRDT- 2015/11/03 06:00
PHST- 2015/11/03 06:00 [entrez]
PHST- 2015/11/03 06:00 [pubmed]
PHST- 2016/10/08 06:00 [medline]
AID - 10.1080/00071668.2015.1113502 [doi]
PST - ppublish
SO  - Br Poult Sci. 2015;56(6):621-30. doi: 10.1080/00071668.2015.1113502.