PMID- 26524361
OWN - NLM
STAT- MEDLINE
DCOM- 20160401
LR  - 20221207
IS  - 1007-3418 (Print)
IS  - 1007-3418 (Linking)
VI  - 23
IP  - 9
DP  - 2015 Sep
TI  - [Relationship between non-alcoholic fatty liver disease and incidence of type 2 
      diabetes mellitus in Chinese adults: a prospective cohort study].
PG  - 675-9
LID - cma.j.issn.1007-3418.2015.09 [pii]
LID - 10.3760/cma.j.issn.1007-3418.2015.09.008 [doi]
AB  - OBJECTIVE: To explore the relationship between nonalcoholic fatty liver disease 
      (NAFLD) and the incidence of type 2 diabetes mellitus (T2DM) in Chinese adults. 
      METHODS: A total of 4847 Chinese adults were enrolled in this prospective study. 
      All participants underwent physical examination at one of three hospitals in 
      Nanjing during 2008. According to results from B ultrasound, the participants 
      were grouped according to NAFLD diagnosis, with 1468 in the NAFLD group and 3379 
      in the control group.Participants were followed up until diagnosis of T2DM or for 
      4 years. The cumulative incidence rates of T2DM were calculated for and compared 
      between the NAFLD group and the control group. The relationship between NAFLD and 
      risk of T2DM was examined by Cox proportional hazards modeling. RESULTS: During 
      the 4-year follow-up,387 (8.0%) of the patients were diagnosed with T2DM. The 
      cumulative incidence rates of T2DM in the NAFLD group and the control group were 
      17.2% and 4.0%, respectively. After adjusting for age,sex,body mass index,blood 
      pressure,triglyceride level and alanine aminotransferase level, NAFLD was found 
      to be closely related to the incidence of T2DM (relative risk:3.465,95% 
      confidence interval:2.755-4.358). CONCLUSION: NAFLD is associated with elevated 
      risk of T2DM in adult patients in Nanjing,China. The general population of this 
      region may benefit from focused public health intervention and treatment 
      strategies targeting to prevent development of T2DM in conjunction with NAFLD.
FAU - Li, Weidong
AU  - Li W
AD  - Department of Gastroenterology, Zhongda Hospital Affiliated to Southeast 
      University, Nanjing 210009, China.
FAU - Fu, Kunfa
AU  - Fu K
FAU - Lian, Yanshu
AU  - Lian Y
FAU - Ren, Aimin
AU  - Ren A
FAU - Chen, Yunju
AU  - Chen Y
FAU - Xia, Jinrong
AU  - Xia J
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Gan Zang Bing Za Zhi
JT  - Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of 
      hepatology
JID - 9710009
SB  - IM
MH  - Adult
MH  - Asian People
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Non-alcoholic Fatty Liver Disease/*epidemiology
MH  - Prospective Studies
MH  - Risk Factors
EDAT- 2015/11/03 06:00
MHDA- 2016/04/02 06:00
CRDT- 2015/11/03 06:00
PHST- 2015/11/03 06:00 [entrez]
PHST- 2015/11/03 06:00 [pubmed]
PHST- 2016/04/02 06:00 [medline]
AID - cma.j.issn.1007-3418.2015.09 [pii]
AID - 10.3760/cma.j.issn.1007-3418.2015.09.008 [doi]
PST - ppublish
SO  - Zhonghua Gan Zang Bing Za Zhi. 2015 Sep;23(9):675-9. doi: 
      10.3760/cma.j.issn.1007-3418.2015.09.008.