PMID- 26525523
OWN - NLM
STAT- MEDLINE
DCOM- 20160907
LR  - 20181113
IS  - 1615-6692 (Electronic)
IS  - 0340-9937 (Linking)
VI  - 40
IP  - 7
DP  - 2015 Nov
TI  - [Baroreflex activation therapy. A novel interventional approach to treat heart 
      failure with reduced ejection fraction].
PG  - 959-65
LID - 10.1007/s00059-015-4361-9 [doi]
AB  - Sympathovagal imbalance plays an important role in the progression of heart 
      failure with reduced ejection fraction. Baroreflex activation therapy (BAT), 
      i. e. electrical stimulation of baroreceptors located at the carotid sinus, can 
      reduce sympathetic and enhance parasympathetic tone. Large animal studies on BAT 
      demonstrated improvements in cardiac function, arrhythmogenic risk and a survival 
      benefit compared to untreated controls. The recently published Neo Randomized 
      Heart Failure Study, the first multicenter, randomized and controlled trial of 
      optimal medical and device therapy alone or plus BAT in patients with a left 
      ventricular ejection fraction </= 35 %, demonstrated a reasonable safety profile of 
      BAT in this severely ill patient population and no relevant interactions with 
      other devices. The study found significant improvements in the New York Heart 
      Association (NYHA) class of heart failure, quality of life as well as 6 min 
      walking distance and data pointed to a reduction in hospitalization rates. 
      Moreover, N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were 
      significantly reduced. This review gives an overview on BAT for the treatment of 
      heart failure with reduced ejection fraction, from the rationale and animal 
      experiments to the most recent clinical data and future perspectives.
FAU - Halbach, M
AU  - Halbach M
AD  - Klinik III fur Innere Medizin, Herzzentrum, Uniklinik Koln, Kerpener Str. 62, 
      50937, Koln, Deutschland. marcel.halbach@uk-koeln.de.
FAU - Fritz, T
AU  - Fritz T
AD  - Klinik III fur Innere Medizin, Herzzentrum, Uniklinik Koln, Kerpener Str. 62, 
      50937, Koln, Deutschland.
FAU - Madershahian, N
AU  - Madershahian N
AD  - Klinik fur Herz- und Thoraxchirurgie, Herzzentrum, Uniklinik Koln, Koln, 
      Deutschland.
FAU - Pfister, R
AU  - Pfister R
AD  - Klinik III fur Innere Medizin, Herzzentrum, Uniklinik Koln, Kerpener Str. 62, 
      50937, Koln, Deutschland.
FAU - Reuter, H
AU  - Reuter H
AD  - Klinik III fur Innere Medizin, Herzzentrum, Uniklinik Koln, Kerpener Str. 62, 
      50937, Koln, Deutschland.
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Baroreflexaktivierungstherapie. Ein neuer interventioneller Ansatz zur Behandlung 
      der systolischen Herzinsuffizienz.
PL  - Germany
TA  - Herz
JT  - Herz
JID - 7801231
SB  - IM
MH  - *Baroreflex
MH  - Chronic Disease
MH  - Electric Stimulation Therapy/*methods
MH  - Evidence-Based Medicine
MH  - Heart Failure/*complications/diagnosis/*prevention & control
MH  - Humans
MH  - Pressoreceptors
MH  - Technology Assessment, Biomedical
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/*complications/diagnosis/*prevention & control
OTO - NOTNLM
OT  - Baroreceptors
OT  - Baroreflex activation therapy
OT  - Carotid sinus stimulation
OT  - Heart failure
OT  - Nervous system
EDAT- 2015/11/04 06:00
MHDA- 2016/09/08 06:00
CRDT- 2015/11/04 06:00
PHST- 2015/11/04 06:00 [entrez]
PHST- 2015/11/04 06:00 [pubmed]
PHST- 2016/09/08 06:00 [medline]
AID - 10.1007/s00059-015-4361-9 [pii]
AID - 10.1007/s00059-015-4361-9 [doi]
PST - ppublish
SO  - Herz. 2015 Nov;40(7):959-65. doi: 10.1007/s00059-015-4361-9.