PMID- 26525536
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151215
LR  - 20220408
IS  - 2193-8253 (Print)
IS  - 2193-6536 (Electronic)
IS  - 2193-6536 (Linking)
VI  - 4
IP  - 2
DP  - 2015 Dec
TI  - Consensus Management of Gastrointestinal Events Associated with Delayed-Release 
      Dimethyl Fumarate: A Delphi Study.
PG  - 137-46
LID - 10.1007/s40120-015-0037-x [doi]
AB  - INTRODUCTION: Delayed-release dimethyl fumarate (DMF, also known as 
      gastro-resistant DMF) is indicated for the treatment of patients with relapsing 
      multiple sclerosis. Gastrointestinal (GI) adverse events (AEs) occur with DMF 
      therapy. METHODS: We used a Delphi process to reach consensus among North 
      American clinicians on effective real-world management strategies for GI AEs 
      associated with DMF. Clinicians were asked to complete two rounds of 
      questionnaires developed by a steering committee; consensus in round 2 was 
      attained if >/=70% of respondents agreed on a particular strategy. RESULTS: 
      Consensus was reached on several strategies to manage GI AEs, including 
      administering DMF with food, slow titration, dose reduction, and use of 
      symptomatic therapies. CONCLUSION: These consensus strategies provide clinicians 
      with information on real-world approaches used to address the tolerability of DMF 
      in patients with multiple sclerosis. FUNDING: Biogen.
FAU - Theodore Phillips, J
AU  - Theodore Phillips J
AD  - Baylor Institute for Immunology Research, Dallas, TX, USA. 
      j.theod.phillips@gmail.com.
FAU - Erwin, April A
AU  - Erwin AA
AD  - NeuroMedical Center Clinic, Baton Rouge, LA, USA.
FAU - Agrella, Stephanie
AU  - Agrella S
AD  - Multiple Sclerosis Clinic of Central Texas, Round Rock, TX, USA.
FAU - Kremenchutzky, Marcelo
AU  - Kremenchutzky M
AD  - Western University and London Health Sciences Centre, London, Canada.
FAU - Kramer, John F
AU  - Kramer JF
AD  - Center For Neurological Disorders, S.C., Milwaukee, WI, USA.
FAU - Darkes, Malcolm J M
AU  - Darkes MJ
AD  - Excel Scientific Solutions, Horsham, UK.
FAU - Kendter, Jonathan
AU  - Kendter J
AD  - Biogen, Weston, MA, USA.
FAU - Abourjaily, Heather
AU  - Abourjaily H
AD  - Biogen, Cambridge, MA, USA.
FAU - Rana, Jitesh
AU  - Rana J
AD  - Biogen, Cambridge, MA, USA.
FAU - Fox, Robert J
AU  - Fox RJ
AD  - Mellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.
LA  - eng
PT  - Journal Article
DEP - 20151102
PL  - New Zealand
TA  - Neurol Ther
JT  - Neurology and therapy
JID - 101637818
PMC - PMC4685868
OTO - NOTNLM
OT  - Delayed-release dimethyl fumarate
OT  - Delphi technique
OT  - Disease management
OT  - Health care surveys
OT  - Multiple sclerosis
EDAT- 2015/11/04 06:00
MHDA- 2015/11/04 06:01
PMCR- 2015/11/02
CRDT- 2015/11/04 06:00
PHST- 2015/09/14 00:00 [received]
PHST- 2015/11/04 06:00 [entrez]
PHST- 2015/11/04 06:00 [pubmed]
PHST- 2015/11/04 06:01 [medline]
PHST- 2015/11/02 00:00 [pmc-release]
AID - 10.1007/s40120-015-0037-x [pii]
AID - 37 [pii]
AID - 10.1007/s40120-015-0037-x [doi]
PST - ppublish
SO  - Neurol Ther. 2015 Dec;4(2):137-46. doi: 10.1007/s40120-015-0037-x. Epub 2015 Nov 
      2.