PMID- 26526038
OWN - NLM
STAT- MEDLINE
DCOM- 20170203
LR  - 20170203
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 53
IP  - 5
DP  - 2016 Jun
TI  - Body mass index, adipokines and insulin resistance in asthmatic children and 
      adolescents.
PG  - 478-84
LID - 10.3109/02770903.2015.1113544 [doi]
AB  - OBJECTIVE: This study aimed to describe the body mass index, insulin resistance, 
      levels of adipokines and inflammatory markers in Brazilian asthmatic children and 
      adolescents and to investigate their possible association with the severity and 
      control of asthma. METHODS: Cross-sectional study (n = 92; age: 3-18 years). 
      Assessed data: Body weight and height, used to calculate the body mass index 
      (BMIZ) and height-for-age (HAZ). Laboratory measurements: Lipid profile; glycemia 
      and insulin for homeostasis model assessment (HOMA); adipokines; tumor necrosis 
      factor alpha (TNF-alpha), C-reactive protein (CRP) and monocyte chemoattractant 
      protein-1 (MCP-1); total immunoglobulin E (IgE) and specific IgE against 
      aeroallergens. RESULTS: The median age was 9.6 years (3.0-16.6); most 
      participants were male (n = 52, 56.5%), pre-pubertal (n = 54, 58.6%) and had 
      atopic asthma (n = 85, 92.4%). Overweight/obesity (38%) showed an inverse 
      correlation with age (adjusted odds ratio [OR] = 0.781; 95% confidence interval 
      [CI] 0.66-0.92) and a direct correlation with the leptin concentration (adjusted 
      OR = 1.13; 95% CI 1.04-1.22). Insulin concentration was independently associated 
      with moderated persistent asthma (adjusted OR = 1.31; 95% CI 1.09-1.52). HOMA 
      showed a direct correlation with the leptin (beta = 0.475; 95% CI 0.117-0.268) and 
      total IgE (beta = 0.197; 95% CI 0.002-0.096) levels and an inverse correlation with 
      the TNF-alpha levels (beta = -0.255; 95% CI;-0.366-0.055). CONCLUSIONS: Asthma was 
      associated with insulin resistance and a systemic inflammatory response possibly 
      mediated by adipokines, with leptin levels standing out among the participants 
      with excess weight.
FAU - Morishita, Rosinha
AU  - Morishita R
AD  - a Department of Paediatrics and.
FAU - Franco, Maria do Carmo
AU  - Franco Mdo C
AD  - b Nephrology Unit, Department of Physiology, Federal University of Sao Paulo , 
      Sao Paulo , Brazil.
FAU - Suano-Souza, Fabiola Isabel
AU  - Suano-Souza FI
AD  - a Department of Paediatrics and.
FAU - Sole, Dirceu
AU  - Sole D
AD  - a Department of Paediatrics and.
FAU - Puccini, Rosana Fiorini
AU  - Puccini RF
AD  - a Department of Paediatrics and.
FAU - Strufaldi, Maria Wany Louzada
AU  - Strufaldi MW
AD  - a Department of Paediatrics and.
LA  - eng
PT  - Journal Article
DEP - 20160120
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Adipokines)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adipokines/*blood
MH  - Adolescent
MH  - Asthma/blood/*epidemiology/immunology
MH  - Body Mass Index
MH  - C-Reactive Protein/analysis
MH  - Chemokine CCL2/blood
MH  - Child
MH  - Child, Preschool
MH  - Cholesterol/blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Male
MH  - Odds Ratio
MH  - Overweight/blood/*epidemiology/immunology
MH  - Severity of Illness Index
MH  - Triglycerides/blood
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - Adipokines
OT  - adolescent
OT  - asthma
OT  - child
OT  - insulin resistance
OT  - obesity
EDAT- 2015/11/04 06:00
MHDA- 2017/02/06 06:00
CRDT- 2015/11/04 06:00
PHST- 2015/11/04 06:00 [entrez]
PHST- 2015/11/04 06:00 [pubmed]
PHST- 2017/02/06 06:00 [medline]
AID - 10.3109/02770903.2015.1113544 [doi]
PST - ppublish
SO  - J Asthma. 2016 Jun;53(5):478-84. doi: 10.3109/02770903.2015.1113544. Epub 2016 
      Jan 20.