PMID- 26526632 OWN - NLM STAT- MEDLINE DCOM- 20160607 LR - 20240213 IS - 1549-4713 (Electronic) IS - 0161-6420 (Print) IS - 0161-6420 (Linking) VI - 123 IP - 2 DP - 2016 Feb TI - Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes. PG - 408-414 LID - S0161-6420(15)01144-6 [pii] LID - 10.1016/j.ophtha.2015.09.047 [doi] AB - PURPOSE: To evaluate and compare the diagnostic accuracy of global and sector analyses for detection of early visual field (VF) damage using the retinal nerve fiber layer (RNFL) reference databases of the Spectralis (Heidelberg Engineering, Heidelberg, Germany) and Cirrus (Carl Zeiss Meditec, Dublin, CA) spectral-domain optical coherence tomography (SD OCT) devices. METHODS: Healthy subjects and glaucoma suspects from the Diagnostic Innovations in Glaucoma Study (DIGS) and African Descent and Glaucoma Evaluation Study (ADAGES) with at least 2 years of follow-up were included. Global and sectoral RNFL measures were classified as within normal limits, borderline (BL), and outside normal limits (ONL) on the basis of the device reference databases. The sensitivity of ONL classification was estimated in glaucoma suspect eyes that developed repeatable VF damage. RESULTS: A total of 353 glaucoma suspect eyes and 279 healthy eyes were included. A total of 34 (9.6%) of the glaucoma suspect eyes developed VF damage. In glaucoma suspect eyes, Spectralis and Cirrus ONL classification was present in 47 eyes (13.3%) and 24 eyes (6.8%), respectively. The sensitivity of the global RNFL ONL classification among eyes that developed VF damage was 23.5% for Cirrus and 32.4% for Spectralis. The specificity of within-normal-limits global classification in healthy eyes was 100% for Cirrus and 99.6% for Spectralis. There was moderate to substantial agreement between Cirrus and Spectralis classification as ONL. CONCLUSIONS: The Spectralis and Cirrus reference databases have a high specificity for identifying healthy eyes and good agreement for detection of eyes with early glaucoma damage. CI - Copyright (c) 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. FAU - Silverman, Anna L AU - Silverman AL AD - Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California; George Washington University School of Medicine and Health Sciences, Washington, District of Columbia. FAU - Hammel, Naama AU - Hammel N AD - Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California. FAU - Khachatryan, Naira AU - Khachatryan N AD - Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California. FAU - Sharpsten, Lucie AU - Sharpsten L AD - Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California. FAU - Medeiros, Felipe A AU - Medeiros FA AD - Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California. FAU - Girkin, Christopher A AU - Girkin CA AD - School of Medicine, University of Alabama, Birmingham, Alabama. FAU - Liebmann, Jeffrey M AU - Liebmann JM AD - Harkness Eye Institute, Columbia University Medical Center, New York, New York. FAU - Weinreb, Robert N AU - Weinreb RN AD - Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California. FAU - Zangwill, Linda M AU - Zangwill LM AD - Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California. Electronic address: lzangwill@ucsd.edu. LA - eng GR - EY08208/EY/NEI NIH HHS/United States GR - K23 EY013959/EY/NEI NIH HHS/United States GR - R01 EY011008/EY/NEI NIH HHS/United States GR - P30 EY022589/EY/NEI NIH HHS/United States GR - U10EY14267/EY/NEI NIH HHS/United States GR - R01 EY019869/EY/NEI NIH HHS/United States GR - P30EY022589/EY/NEI NIH HHS/United States GR - EY13959/EY/NEI NIH HHS/United States GR - R01 EY021818/EY/NEI NIH HHS/United States GR - R01 EY008208/EY/NEI NIH HHS/United States GR - EY021818/EY/NEI NIH HHS/United States GR - EY019869/EY/NEI NIH HHS/United States GR - EY11008/EY/NEI NIH HHS/United States GR - U10 EY014267/EY/NEI NIH HHS/United States GR - R01 EY022039/EY/NEI NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20151031 PL - United States TA - Ophthalmology JT - Ophthalmology JID - 7802443 SB - IM MH - Black or African American/ethnology MH - Aged MH - Databases, Factual MH - Early Diagnosis MH - Gonioscopy MH - Healthy Volunteers MH - Humans MH - Middle Aged MH - Nerve Fibers/*pathology MH - Ocular Hypertension/*diagnosis/ethnology MH - Reproducibility of Results MH - Retinal Ganglion Cells/*pathology MH - Sensitivity and Specificity MH - Tomography, Optical Coherence/*instrumentation/methods MH - Vision Disorders/*diagnosis MH - Visual Field Tests MH - *Visual Fields PMC - PMC4724549 MID - NIHMS734968 EDAT- 2015/11/04 06:00 MHDA- 2016/06/09 06:00 PMCR- 2017/02/01 CRDT- 2015/11/04 06:00 PHST- 2015/02/11 00:00 [received] PHST- 2015/09/28 00:00 [revised] PHST- 2015/09/30 00:00 [accepted] PHST- 2015/11/04 06:00 [entrez] PHST- 2015/11/04 06:00 [pubmed] PHST- 2016/06/09 06:00 [medline] PHST- 2017/02/01 00:00 [pmc-release] AID - S0161-6420(15)01144-6 [pii] AID - 10.1016/j.ophtha.2015.09.047 [doi] PST - ppublish SO - Ophthalmology. 2016 Feb;123(2):408-414. doi: 10.1016/j.ophtha.2015.09.047. Epub 2015 Oct 31.