PMID- 26527209
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151103
LR  - 20220330
IS  - 2233-6834 (Print)
IS  - 2233-6842 (Electronic)
IS  - 2233-6834 (Linking)
VI  - 19
IP  - 3
DP  - 2015 Sep
TI  - Exercise copes with prolonged stress-induced impairment of spatial memory 
      performance by endoplasmic reticulum stress.
PG  - 191-7
LID - 10.5717/jenb.2015.15080705 [doi]
AB  - The present study demonstrates that prolonged restraint administration for 21 
      days caused memory impairment and induced hippocampal endoplasmic reticulum (ER) 
      stress-mediated apoptosis. On the contrary, this change was revered by treadmill 
      running for 8 weeks. Repeated psychological stress caused an increase in escape 
      latency time in the water maze test, accompanied by the induction of 
      glucose-regulated protein 78 (GRP78), CCAAT/enhancer-binding protein homologous 
      protein (CHOP), and cleaved/active caspase-12 protein in the hippocampus. The 
      expression pattern of ER stress response-related proteins were counter-regulated 
      by chronic exercise, as indicated by a reduction in GRP78, CHOP, and cleaved 
      caspase-12, along with a decrease in escape latency time. In addition, the 
      hippocampal expression pattern of phospho-cAMP response element-binding protein 
      (CREB) and brain-derived neurotrophic factor (BDNF) opposed that of ER stress 
      response components. Accordingly, chronic exercise may attenuate prolonged 
      stress-induced hippocampal ER stress and memory deficit, likely through CREB/BDNF 
      signaling.
FAU - Kang, Jong-Seok
AU  - Kang JS
AD  - Exercise Biochemistry Laboratory, Korea National Sport University, Seoul, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20150831
PL  - Korea (South)
TA  - J Exerc Nutrition Biochem
JT  - Journal of exercise nutrition & biochemistry
JID - 101572566
PMC - PMC4624120
OTO - NOTNLM
OT  - CHOP
OT  - endoplasmic reticulum stress
OT  - exercise
OT  - glucose-regulated protein 78
OT  - memory
OT  - prolonged stress
EDAT- 2015/11/04 06:00
MHDA- 2015/11/04 06:01
PMCR- 2015/09/01
CRDT- 2015/11/04 06:00
PHST- 2015/06/03 00:00 [received]
PHST- 2015/08/02 00:00 [revised]
PHST- 2015/08/07 00:00 [accepted]
PHST- 2015/11/04 06:00 [entrez]
PHST- 2015/11/04 06:00 [pubmed]
PHST- 2015/11/04 06:01 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - jenb-19-3-191 [pii]
AID - 10.5717/jenb.2015.15080705 [doi]
PST - ppublish
SO  - J Exerc Nutrition Biochem. 2015 Sep;19(3):191-7. doi: 10.5717/jenb.2015.15080705. 
      Epub 2015 Aug 31.