PMID- 26527246
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20191210
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 169
IP  - 1-3
DP  - 2015 Dec
TI  - Baseline putamen volume as a predictor of positive symptom reduction in patients 
      at clinical high risk for psychosis: A preliminary study.
PG  - 178-185
LID - S0920-9964(15)30030-X [pii]
LID - 10.1016/j.schres.2015.10.029 [doi]
AB  - OBJECTIVES: Illness course in individuals at clinical high risk (CHR) status for 
      psychosis is heterogeneous, which limits effective treatment for all CHR 
      subgroups. Baseline predictors of positive symptom trajectory in the CHR group 
      will reduce such limitations. We singled out the putamen, thought to be involved 
      in the generation of the key schizophrenia symptoms early in the course of 
      disease, as a potential predictor of positive symptom trajectory in CHR patients. 
      METHOD: We recruited 45 CHR patients and 29 age- and gender-matched healthy 
      controls (HC). The CHR group was divided into patients with positive symptom 
      reduction (CHR-R) and patients without positive symptom reduction (CHR-NR) at 6 
      months. Comparisons were made between the baseline putamen volumes of CHR-R, 
      CHR-NR and HC groups. The relationship between baseline putamen volumes and 
      clinical measures was investigated. RESULTS: Left putamen volumes of CHR-R 
      patients were significantly smaller than those of HCs (p=0.002) and of CHR-NR 
      patients (p=0.024). CHR-R patients had significantly reduced leftward laterality 
      compared to HCs (p=0.007). In the CHR-R group, bilateral putamen volumes were 
      correlated with positive symptom severity at baseline (r=-0.552, p=0.001) and at 
      6 months (r=-0.360, p=0.043), and predicted positive symptom score change in 6 
      months at a trend level (p=0.092). CONCLUSION: Smaller left putamen volumes in 
      CHR-R patients, and the correlation between positive symptom severity and putamen 
      volumes suggest that putamen volume is a possible risk-stratifier and predictor 
      of clinical course in the CHR population.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Hong, Sang Bin
AU  - Hong SB
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Lee, Tae Young
AU  - Lee TY
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea; Medical Research Center, Seoul National University College of 
      Medicine, Seoul, Republic of Korea. Electronic address: leetaey@snu.ac.kr.
FAU - Kwak, Yoo Bin
AU  - Kwak YB
AD  - Department of Brain & Cognitive Sciences, Seoul National University College of 
      National Sciences, Seoul, Republic of Korea.
FAU - Kim, Sung Nyun
AU  - Kim SN
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kwon, Jun Soo
AU  - Kwon JS
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea; Medical Research Center, Seoul National University College of 
      Medicine, Seoul, Republic of Korea; Department of Brain & Cognitive Sciences, 
      Seoul National University College of National Sciences, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151031
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Analysis of Variance
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Disease Progression
MH  - Female
MH  - Functional Laterality
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Outcome Assessment, Health Care
MH  - Prodromal Symptoms
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*pathology
MH  - Putamen/*pathology
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Clinical high risk
OT  - Positive symptom
OT  - Predictors
OT  - Psychosis
OT  - Putamen
EDAT- 2015/11/04 06:00
MHDA- 2016/09/27 06:00
CRDT- 2015/11/04 06:00
PHST- 2015/06/22 00:00 [received]
PHST- 2015/10/13 00:00 [revised]
PHST- 2015/10/20 00:00 [accepted]
PHST- 2015/11/04 06:00 [entrez]
PHST- 2015/11/04 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
AID - S0920-9964(15)30030-X [pii]
AID - 10.1016/j.schres.2015.10.029 [doi]
PST - ppublish
SO  - Schizophr Res. 2015 Dec;169(1-3):178-185. doi: 10.1016/j.schres.2015.10.029. Epub 
      2015 Oct 31.