PMID- 26527617
OWN - NLM
STAT- MEDLINE
DCOM- 20160517
LR  - 20201209
IS  - 1098-5549 (Electronic)
IS  - 0270-7306 (Print)
IS  - 0270-7306 (Linking)
VI  - 36
IP  - 2
DP  - 2016 Jan 15
TI  - Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor 
      Cluster Formation.
PG  - 262-70
LID - 10.1128/MCB.00775-15 [doi]
AB  - Crk and CrkL are noncatalytic adaptor proteins necessary for the formation of 
      neuromuscular synapses which function downstream of muscle-specific kinase 
      (MuSK), a receptor tyrosine kinase expressed in skeletal muscle, and the MuSK 
      binding protein Dok-7. How Crk/CrkL regulate neuromuscular endplate formation is 
      not known. To better understand the roles of Crk/CrkL, we identified CrkL binding 
      proteins using mass spectrometry and have identified Sorbs1 and Sorbs2 as two 
      functionally redundant proteins that associate with the initiating 
      MuSK/Dok-7/Crk/CrkL complex, regulate acetylcholine receptor (AChR) clustering in 
      vitro, and are localized at synapses in vivo.
CI  - Copyright (c) 2016 Hallock et al.
FAU - Hallock, Peter T
AU  - Hallock PT
AD  - Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
FAU - Chin, Sherry
AU  - Chin S
AD  - Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
FAU - Blais, Steven
AU  - Blais S
AD  - Skirball Institute of Biomolecular Medicine, New York University School of 
      Medicine, New York, New York, USA.
FAU - Neubert, Thomas A
AU  - Neubert TA
AD  - Skirball Institute of Biomolecular Medicine, New York University School of 
      Medicine, New York, New York, USA.
FAU - Glass, David J
AU  - Glass DJ
AD  - Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA 
      david.glass@novartis.com.
LA  - eng
GR  - P30 NS050276/NS/NINDS NIH HHS/United States
GR  - S10 RR027990/RR/NCRR NIH HHS/United States
GR  - S10RR027990/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20151102
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (CRKL protein)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (Receptors, Cholinergic)
RN  - 0 (Sorbs2 protein, mouse)
RN  - 0 (ponsin)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/*metabolism
MH  - Animals
MH  - Cell Line
MH  - Mice
MH  - Microfilament Proteins/genetics/*metabolism
MH  - Muscle Fibers, Skeletal/*metabolism
MH  - Mutation
MH  - Myoblasts/metabolism
MH  - Nuclear Proteins/*metabolism
MH  - Protein Interaction Maps
MH  - RNA Interference
MH  - RNA, Small Interfering/genetics
MH  - RNA-Binding Proteins
MH  - Receptors, Cholinergic/*metabolism
PMC - PMC4719301
EDAT- 2015/11/04 06:00
MHDA- 2016/05/18 06:00
PMCR- 2016/01/04
CRDT- 2015/11/04 06:00
PHST- 2015/08/07 00:00 [received]
PHST- 2015/10/23 00:00 [accepted]
PHST- 2015/11/04 06:00 [entrez]
PHST- 2015/11/04 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
PHST- 2016/01/04 00:00 [pmc-release]
AID - MCB.00775-15 [pii]
AID - 00775-15 [pii]
AID - 10.1128/MCB.00775-15 [doi]
PST - epublish
SO  - Mol Cell Biol. 2015 Nov 2;36(2):262-70. doi: 10.1128/MCB.00775-15. Print 2016 Jan 
      15.