PMID- 26528103
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151103
LR  - 20200930
IS  - 1643-8876 (Print)
IS  - 2299-0038 (Electronic)
IS  - 1643-8876 (Linking)
VI  - 14
IP  - 3
DP  - 2015 Sep
TI  - Polymorphisms of estrogen metabolism-related genes ESR1, UGT2B17, and UGT1A1 are 
      not associated with osteoporosis in surgically menopausal Japanese women.
PG  - 161-7
LID - 10.5114/pm.2015.54339 [doi]
AB  - INTRODUCTION: Bilateral salpingo-oophorectomy (BSO) is a risk factor for 
      osteoporosis. Previous studies have reported an association between genetic 
      polymorphisms and the risk of developing osteoporosis. However, the relationship 
      between osteoporosis and genetic polymorphisms in Japanese women treated with BSO 
      is not well understood. To improve the quality of life for post-BSO patients, it 
      is important to determine the genetic factors that influence their risk for 
      osteoporosis. The aim of this study was to investigate the association between 
      gene variations of estrogen metabolism-related genes and osteoporosis in 
      surgically menopausal patients, which may improve their quality of life. MATERIAL 
      AND METHODS: This study included 203 menopausal women treated with BSO because of 
      gynecologic disorders. One hundred and twenty-six women with artificial 
      (surgical) menopause, who had undergone BSO in the premenopausal period, were 
      compared with 77 women with natural menopause, who had undergone BSO in the 
      postmenopausal period. The women were tested for bone mineral density to diagnose 
      osteoporosis. Polymorphisms of estrogen receptor 1 (ESR1) and UDP-glucuronosyl 
      transferase (UGT) genes UGT2B17 and UGT1A1 were analyzed, and their association 
      with bone mass and osteoporosis was statistically evaluated. RESULTS: No 
      significant association was found between osteoporosis and polymorphisms in ESR1, 
      UGT2B17, or UGT1A1 in both groups, suggesting that BSO might be a more 
      significant physiological factor in influencing bone mass density compared to 
      genetic variations. CONCLUSIONS: These results suggest that the ESR1, UGT2B17, 
      and UGT1A1 polymorphisms are not genetic factors affecting osteoporosis in 
      postmenopausal Japanese women.
FAU - Yokota, Megumi
AU  - Yokota M
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Hirasawa, Akira
AU  - Hirasawa A
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Makita, Kazuya
AU  - Makita K
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Akahane, Tomoko
AU  - Akahane T
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Sakai, Kensuke
AU  - Sakai K
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Makabe, Takeshi
AU  - Makabe T
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Horiba, Yuko
AU  - Horiba Y
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Yamagami, Wataru
AU  - Yamagami W
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Ogawa, Mariko
AU  - Ogawa M
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Iwata, Takashi
AU  - Iwata T
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Yanamoto, Shigehisa
AU  - Yanamoto S
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Deshimaru, Ryota
AU  - Deshimaru R
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Banno, Kouji
AU  - Banno K
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Susumu, Nobuyuki
AU  - Susumu N
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
FAU - Aoki, Daisuke
AU  - Aoki D
AD  - Department of Obstetrics and Gynecology, Keio University School of Medicine, 
      Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20150930
PL  - Poland
TA  - Prz Menopauzalny
JT  - Przeglad menopauzalny = Menopause review
JID - 101263235
PMC - PMC4612551
OTO - NOTNLM
OT  - bilateral salpingo-oophorectomy
OT  - bone mineral density
OT  - gene polymorphism
OT  - menopause
OT  - osteoporosis
EDAT- 2015/11/04 06:00
MHDA- 2015/11/04 06:01
PMCR- 2015/09/01
CRDT- 2015/11/04 06:00
PHST- 2015/07/01 00:00 [received]
PHST- 2015/07/23 00:00 [revised]
PHST- 2015/08/20 00:00 [accepted]
PHST- 2015/11/04 06:00 [entrez]
PHST- 2015/11/04 06:00 [pubmed]
PHST- 2015/11/04 06:01 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - 25799 [pii]
AID - 10.5114/pm.2015.54339 [doi]
PST - ppublish
SO  - Prz Menopauzalny. 2015 Sep;14(3):161-7. doi: 10.5114/pm.2015.54339. Epub 2015 Sep 
      30.