PMID- 26528289
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151103
LR  - 20181113
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 6
DP  - 2015
TI  - Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets.
PG  - 527
LID - 10.3389/fimmu.2015.00527 [doi]
LID - 527
AB  - Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) that have a 
      key role in immune responses because they bridge the innate and adaptive arms of 
      the immune system. They mature upon recognition of pathogens and upregulate MHC 
      molecules and costimulatory receptors to activate antigen-specific CD4(+) and 
      CD8(+) T cells. It is now well established that DCs are not a homogeneous 
      population but are composed of different subsets with specialized functions in 
      immune responses to specific pathogens. Upon viral infections, plasmacytoid DCs 
      (pDCs) rapidly produce large amounts of IFN-alpha, which has potent antiviral 
      functions and activates several other immune cells. However, pDCs are not 
      particularly potent APCs and induce the tolerogenic cytokine IL-10 in CD4(+) T 
      cells. In contrast, myeloid DCs (mDCs) are very potent APCs and possess the 
      unique capacity to prime naive T cells and consequently to initiate a primary 
      adaptive immune response. Different subsets of mDCs with specialized functions 
      have been identified. In mice, CD8alpha(+) mDCs capture antigenic material from 
      necrotic cells, secrete high levels of IL-12, and prime Th1 and cytotoxic T-cell 
      responses to control intracellular pathogens. Conversely, CD8alpha(-) mDCs 
      preferentially prime CD4(+) T cells and promote Th2 or Th17 differentiation. 
      BDCA-3(+) mDC2 are the human homologue of CD8alpha(+) mDCs, since they share the 
      expression of several key molecules, the capacity to cross-present antigens to 
      CD8(+) T-cells and to produce IFN-lambda. However, although several features of the DC 
      network are conserved between humans and mice, the expression of several 
      toll-like receptors as well as the production of cytokines that regulate T-cell 
      differentiation are different. Intriguingly, recent data suggest specific roles 
      for human DC subsets in immune responses against individual pathogens. The 
      biology of human DC subsets holds the promise to be exploitable in translational 
      medicine, in particular for the development of vaccines against persistent 
      infections or cancer.
FAU - Geginat, Jens
AU  - Geginat J
AD  - Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi" (INGM) , 
      Milan , Italy.
FAU - Nizzoli, Giulia
AU  - Nizzoli G
AD  - Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi" (INGM) , 
      Milan , Italy.
FAU - Paroni, Moira
AU  - Paroni M
AD  - Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi" (INGM) , 
      Milan , Italy.
FAU - Maglie, Stefano
AU  - Maglie S
AD  - Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi" (INGM) , 
      Milan , Italy.
FAU - Larghi, Paola
AU  - Larghi P
AD  - Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi" (INGM) , 
      Milan , Italy.
FAU - Pascolo, Steve
AU  - Pascolo S
AD  - Department of Dermatology, University Hospital of Zurich , Zurich , Switzerland.
FAU - Abrignani, Sergio
AU  - Abrignani S
AD  - Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi" (INGM) , 
      Milan , Italy ; DISCCO, Department of Clinical Sciences and Community Health, 
      University of Milano , Milan , Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151013
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC4603245
OTO - NOTNLM
OT  - T-cell differentiation
OT  - cytokines
OT  - cytotoxic T cells
OT  - dendritic cells
OT  - toll-like receptors
EDAT- 2015/11/04 06:00
MHDA- 2015/11/04 06:01
PMCR- 2015/01/01
CRDT- 2015/11/04 06:00
PHST- 2015/07/29 00:00 [received]
PHST- 2015/09/28 00:00 [accepted]
PHST- 2015/11/04 06:00 [entrez]
PHST- 2015/11/04 06:00 [pubmed]
PHST- 2015/11/04 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2015.00527 [doi]
PST - epublish
SO  - Front Immunol. 2015 Oct 13;6:527. doi: 10.3389/fimmu.2015.00527. eCollection 
      2015.