PMID- 26528333
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151103
LR  - 20220408
IS  - 1734-1922 (Print)
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 11
IP  - 5
DP  - 2015 Oct 12
TI  - Association of polymorphism in adiponectin (+45 T/G) and leptin (-2548 G/A) genes 
      with type 2 diabetes mellitus in male Egyptians.
PG  - 937-44
LID - 10.5114/aoms.2015.54848 [doi]
AB  - INTRODUCTION: Adiponectin is an adipose tissue-specific protein with 
      insulin-sensitizing properties. Many investigators have explored the association 
      between adiponectin single nucleotide polymorphisms (SNPs) and type 2 diabetes 
      mellitus (T2DM) in different ethnic populations from different regions. Leptin is 
      a protein hormone constituting an important signal in the regulation of adipose 
      tissue mass and body weight. The aim of this study was to explore potential 
      associations between SNP +45 T>G of the adiponectin gene and SNP 2548G/A of 
      leptin with T2DM and the effect of SNPs on serum adiponectin and leptin levels. 
      MATERIAL AND METHODS: From the Egyptian population, we enrolled 110 T2DM patients 
      and 90 non-diabetic controls. Serum lipid profile, blood glucose, serum 
      adiponectin, and leptin were measured. Genotyping for two common SNPs of the 
      adiponectin and leptin genes was performed by polymerase chain 
      reaction-restriction fragment length polymorphism. RESULTS: The G allele and 
      TG/GG genotype of SNP 45 occurred more frequently than the T allele and TT 
      genotype in T2DM patients compares to the controls. Subjects with the GG + TG 
      genotype of SNP 45 were at increased risk for T2DM (OR = 6.476; 95% CI: 
      3.401-12.33) and associated with a low serum adiponectin level compared with the 
      TT genotype. The serum leptin concentration of GA + AA genotype carriers was not 
      significantly different from that of the GG genotype in the diabetic group. 
      CONCLUSIONS: The G allele carriers who have reduced plasma concentrations of 
      adiponectin may have an association with T2DM, while leptin SNP 2548 G/A is not 
      associated with the risk of development of T2DM in the Egyptian population.
FAU - Motawi, Tarek
AU  - Motawi T
AD  - Faculty of Pharmacy, Cairo University, Cairo, Egypt.
FAU - Salman, Tarek
AU  - Salman T
AD  - Faculty of Pharmacy, Al Azhar University, Cairo, Egypt.
FAU - Shaker, Olfat
AU  - Shaker O
AD  - Faculty of Medicine, Cairo University, Cairo, Egypt.
FAU - Abdelhamid, Amr
AU  - Abdelhamid A
AD  - Faculty of Pharmacy, MSA University, Giza, Egypt.
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC4624740
OTO - NOTNLM
OT  - polymerase chain reaction-restriction fragment length polymorphism
OT  - single nucleotide polymorphism
EDAT- 2015/11/04 06:00
MHDA- 2015/11/04 06:01
PMCR- 2015/10/12
CRDT- 2015/11/04 06:00
PHST- 2013/08/13 00:00 [received]
PHST- 2013/08/29 00:00 [revised]
PHST- 2013/10/06 00:00 [accepted]
PHST- 2015/11/04 06:00 [entrez]
PHST- 2015/11/04 06:00 [pubmed]
PHST- 2015/11/04 06:01 [medline]
PHST- 2015/10/12 00:00 [pmc-release]
AID - 25964 [pii]
AID - 10.5114/aoms.2015.54848 [doi]
PST - ppublish
SO  - Arch Med Sci. 2015 Oct 12;11(5):937-44. doi: 10.5114/aoms.2015.54848.