PMID- 26530628
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20220310
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 169
IP  - 1-3
DP  - 2015 Dec
TI  - Modeling the role of negative symptoms in determining social functioning in 
      individuals at clinical high risk of psychosis.
PG  - 204-208
LID - S0920-9964(15)30036-0 [pii]
LID - 10.1016/j.schres.2015.10.036 [doi]
AB  - A priority for improving outcome in individuals at clinical high risk (CHR) is 
      enhancing our understanding of predictors of psychosis as well as psychosocial 
      functioning. Social functioning, in particular, is a unique indicator of risk as 
      well as an important outcome in itself. Negative symptoms are a significant 
      determinant of social functioning in CHR individuals; yet, it is unclear which 
      specific negative symptoms drive functional outcome and how these symptoms 
      function relative to other predictors, such as neurocognition and mood/anxiety 
      symptoms. In a sample of 85 CHR individuals, we examined whether a two-factor 
      negative symptom structure that is found in schizophrenia (experiential vs 
      expressive symptoms) would be replicated in a CHR sample; and tested the degree 
      to which specific negative symptoms predict social functioning, relative to 
      neurocognition and mood/anxiety symptoms, which are known to predict functioning. 
      The two-factor negative symptom solution was replicated in this CHR sample. 
      Negative symptom severity was found to be uniquely predictive of social 
      functioning, above and beyond depression/anxiety and neurocognition. Experiential 
      symptoms were more strongly associated with social functioning, relative to 
      expression symptoms. In addition, experiential symptoms mediated the relationship 
      between expressive negative symptoms and social functioning. These results 
      suggest that experiences of motivational impairment are more important in 
      determining social functioning, relative to affective flattening and alogia, in 
      CHR individuals, thereby informing the development of more precise therapeutic 
      targets. Developing novel interventions that stimulate goal-directed behavior and 
      reinforce rewarding experiences in social contexts are recommended.
CI  - Copyright (c) 2015. Published by Elsevier B.V.
FAU - Schlosser, Danielle A
AU  - Schlosser DA
AD  - University of California at San Francisco, United States. Electronic address: 
      Danielle.schlosser@ucsf.edu.
FAU - Campellone, Timothy R
AU  - Campellone TR
AD  - University of California at San Francisco, United States; University of 
      California at Berkeley, United States.
FAU - Biagianti, Bruno
AU  - Biagianti B
AD  - University of California at San Francisco, United States.
FAU - Delucchi, Kevin L
AU  - Delucchi KL
AD  - University of California at San Francisco, United States.
FAU - Gard, David E
AU  - Gard DE
AD  - San Francisco State University, United States.
FAU - Fulford, Daniel
AU  - Fulford D
AD  - Boston University, United States.
FAU - Stuart, Barbara K
AU  - Stuart BK
AD  - University of California at San Francisco, United States.
FAU - Fisher, Melissa
AU  - Fisher M
AD  - University of California at San Francisco, United States; San Francisco Veterans 
      Affairs Medical Center, United States.
FAU - Loewy, Rachel L
AU  - Loewy RL
AD  - University of California at San Francisco, United States.
FAU - Vinogradov, Sophia
AU  - Vinogradov S
AD  - University of California at San Francisco, United States; San Francisco Veterans 
      Affairs Medical Center, United States.
LA  - eng
GR  - K23 MH097795-01/MH/NIMH NIH HHS/United States
GR  - R01 01MH081051/MH/NIMH NIH HHS/United States
GR  - R34 MH100399/MH/NIMH NIH HHS/United States
GR  - R01 MH081051/MH/NIMH NIH HHS/United States
GR  - K23 MH097795/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20151031
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Female
MH  - Humans
MH  - Male
MH  - *Prodromal Symptoms
MH  - Psychotic Disorders/*physiopathology/*psychology
MH  - Risk Factors
MH  - *Social Adjustment
MH  - Social Behavior Disorders/*diagnosis
MH  - Statistics as Topic
MH  - Young Adult
PMC - PMC4681660
MID - NIHMS740015
OTO - NOTNLM
OT  - Experiential negative symptoms
OT  - Expressive negative symptoms
OT  - Motivation
OT  - Prodromal
OT  - Psychosis
OT  - Social functioning
COIS- Conflict of Interest We wish to confirm that there are no known conflicts of 
      interest associated with this publication and there has been no significant 
      financial support for this work that could have influenced its outcome.
EDAT- 2015/11/05 06:00
MHDA- 2016/09/27 06:00
PMCR- 2016/12/01
CRDT- 2015/11/05 06:00
PHST- 2015/07/31 00:00 [received]
PHST- 2015/10/23 00:00 [revised]
PHST- 2015/10/24 00:00 [accepted]
PHST- 2015/11/05 06:00 [entrez]
PHST- 2015/11/05 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - S0920-9964(15)30036-0 [pii]
AID - 10.1016/j.schres.2015.10.036 [doi]
PST - ppublish
SO  - Schizophr Res. 2015 Dec;169(1-3):204-208. doi: 10.1016/j.schres.2015.10.036. Epub 
      2015 Oct 31.