PMID- 26531107
OWN - NLM
STAT- MEDLINE
DCOM- 20170418
LR  - 20181202
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 65
IP  - 12
DP  - 2015 Dec
TI  - Is ALK-gene rearrangement overlooked in primary gastrointestinal T-cell 
      lymphomas? About two cases.
PG  - 666-70
LID - 10.1111/pin.12358 [doi]
AB  - A 41-year-old male patient with a history of ankylosing spondylitis and Crohn 
      disease, treated with immunomodulators and disease-modifying drugs, was diagnosed 
      with a primary intestinal T-cell lymphoma that followed a 7.5-year-course. This 
      transmural proliferation lacked cytological characteristics of anaplastic large 
      cell lymphoma (ALCL), and was CD8-positive, and CD30- and anaplastic lymphoma 
      kinase (ALK)-negative by immunohistochemistry (IHC). However, ALK-gene 
      rearrangement (ALK-gr) was detected by fluorescence in situ hybridization (FISH) 
      in both initial and persistent disease. The possibility of indolent T-cell 
      lymphoproliferative disease of the gastrointestinal tract with atypical features 
      (transmural involvement) related to ALK-gr was suggested. A previous case of 
      aggressive 'enteropathy-associated ALCL' in the context of celiac disease was 
      recently reported, which also lacked anaplastic morphology, and where CD30 and 
      ALK expression was incidentally demonstrated by IHC, and ALK-gr subsequently 
      confirmed by FISH. These two recent cases represent two distinct rare entities 
      pertaining to the group of primary intestinal T-cell lymphomas, and they both 
      show unexpected ALK-gr. This suggests that ALK-gr has been overlooked in the 
      group of primary intestinal T-cell lymphomas. Performing IHC and FISH tests for 
      ALK-gr in primary gastrointestinal T-cell lymphomas might be of importance, 
      particularly with the advancement of targeted therapy that could impact treatment 
      and prognosis.
CI  - (c) 2015 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd.
FAU - Mneimneh, Wadad S
AU  - Mneimneh WS
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, Indiana, USA.
FAU - Vyas, Shikhar Gautam
AU  - Vyas SG
AD  - Department of Internal Medicine, Indiana University School of Medicine, Indiana 
      University Health Hospital, Indianapolis, Indiana, USA.
FAU - Cheng, Liang
AU  - Cheng L
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, Indiana, USA.
FAU - Cummings, Oscar W
AU  - Cummings OW
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, Indiana, USA.
FAU - Czader, Magdalena
AU  - Czader M
AD  - Department of Pathology and Laboratory Medicine, Division of Hematopathology, 
      Indianapolis, Indiana, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20151104
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Ki-1 Antigen)
RN  - EC 2.7.10.1 (ALK protein, human)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anaplastic Lymphoma Kinase
MH  - Diagnosis, Differential
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Intestinal Neoplasms/*genetics/pathology
MH  - Ki-1 Antigen/*metabolism
MH  - Lymphoma, T-Cell/*genetics/pathology
MH  - Male
MH  - Receptor Protein-Tyrosine Kinases/*genetics/metabolism
MH  - Translocation, Genetic
OTO - NOTNLM
OT  - anaplastic large T-cell lymphoma
OT  - anaplastic lymphoma kinase
OT  - enteropathy associated T-cell lymphoma
OT  - indolent T-cell lymphoproliferative disorder of the GI tract
OT  - intestinal T-cell lymphoma
EDAT- 2015/11/05 06:00
MHDA- 2017/04/19 06:00
CRDT- 2015/11/05 06:00
PHST- 2015/06/27 00:00 [received]
PHST- 2015/10/10 00:00 [accepted]
PHST- 2015/11/05 06:00 [entrez]
PHST- 2015/11/05 06:00 [pubmed]
PHST- 2017/04/19 06:00 [medline]
AID - 10.1111/pin.12358 [doi]
PST - ppublish
SO  - Pathol Int. 2015 Dec;65(12):666-70. doi: 10.1111/pin.12358. Epub 2015 Nov 4.