PMID- 26531275
OWN - NLM
STAT- MEDLINE
DCOM- 20160622
LR  - 20220330
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 19
IP  - 20
DP  - 2015 Oct
TI  - Effect of different anesthesia techniques on the serum brain-derived neurotrophic 
      factor (BDNF) levels.
PG  - 3886-94
LID - 9674 [pii]
AB  - OBJECTIVE: Serum Brain-Derived Neurotrophic Factor (BDNF) levels are associated 
      with neurotransmission and cognitive functions. The goal of this study was to 
      examine the effect of general anesthesia on BDNF levels. It was also to reveal 
      whether this effect had a relationship with the surgical stress response or not. 
      PATIENTS AND METHODS: The study included 50 male patients, age 20-40, who were 
      scheduled to have inguinoscrotal surgery, and who were in the ASA I-II risk 
      group. The patients were divided into two groups according to the anesthesia 
      techniques used: general (GA) and spinal (SA). In order to measure serum BDNF, 
      cortisol, insulin and glucose levels, blood samples were taken at four different 
      times: before and after anesthesia, end of the surgery, and before transferal 
      from the recovery room. RESULTS: Serum BDNF levels were significantly low (p < 
      0.01), cortisol and glucose levels were higher (p < 0.05 and p < 0.01) in Group 
      GA compared with Group SA. No significant difference was detected between the 
      groups in terms of serum insulin levels. There was no correlation between serum 
      BDNF and the stress hormones. CONCLUSIONS: Our findings suggested that general 
      anesthetics had an effect on serum BDNF levels independent of the stress 
      response. In future, BDNF could be used as biochemical parameters of anesthesia 
      levels, but studies with a greater scope should be carried out to present the 
      relationship between anesthesia and neurotrophins.
FAU - Ozer, A B
AU  - Ozer AB
AD  - Department of Anesthesiology and Reanimation, Firat University, Faculty of 
      Medicine, Elazig, Turkey. abelinozer@gmail.com.
FAU - Demirel, I
AU  - Demirel I
FAU - Erhan, O L
AU  - Erhan OL
FAU - Firdolas, F
AU  - Firdolas F
FAU - Ustundag, B
AU  - Ustundag B
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Insulin)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Anesthesia, General/*methods/trends
MH  - Anesthesia, Spinal/*methods/trends
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Insulin/blood
MH  - Male
MH  - Prospective Studies
MH  - Young Adult
EDAT- 2015/11/05 06:00
MHDA- 2016/06/23 06:00
CRDT- 2015/11/05 06:00
PHST- 2015/11/05 06:00 [entrez]
PHST- 2015/11/05 06:00 [pubmed]
PHST- 2016/06/23 06:00 [medline]
AID - 9674 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2015 Oct;19(20):3886-94.