PMID- 26535083
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151104
LR  - 20240324
IS  - 1976-9148 (Print)
IS  - 2005-4483 (Electronic)
IS  - 1976-9148 (Linking)
VI  - 23
IP  - 6
DP  - 2015 Nov
TI  - Effect of Beta-Asarone on Impairment of Spatial Working Memory and Apoptosis in 
      the Hippocampus of Rats Exposed to Chronic Corticosterone Administration.
PG  - 571-81
LID - 10.4062/biomolther.2015.027 [doi]
AB  - beta-asarone (BAS) is an active component of Acori graminei rhizoma, a traditional 
      medicine used clinically in treating dementia and chronic stress in Korea. 
      However, the cognitive effects of BAS and its mechanism of action have remained 
      elusive. The purpose of this study was to examine whether BAS improved spatial 
      cognitive impairment induced in rats following chronic corticosterone (CORT) 
      administration. CORT administration (40 mg/kg, i.p., 21 days) resulted in 
      cognitive impairment in the avoidance conditioning test (AAT) and the Morris 
      water maze (MWM) test that was reversed by BAS (200 mg/kg, i.p). Additionally, as 
      assessed by immunohistochemistry and RT-PCR analysis, the administration of BAS 
      significantly alleviated memory-associated decreases in the expression levels of 
      brain-derived neurotrophic factor (BDNF) and cAMP-response element-binding 
      protein (CREB) proteins and mRNAs in the hippocampus. Also, BAS administration 
      significantly restored the expression of Bax and Bcl-2 mRNAs in the hippocampus. 
      Thus, BAS may be an effective therapeutic for learning and memory disturbances, 
      and its neuroprotective effect was mediated, in part, by normalizing the CORT 
      response, resulting in regulation of BDNF and CREB functions and anti-apoptosis 
      in rats.
FAU - Lee, Bombi
AU  - Lee B
AD  - Acupuncture and Meridian Science Research Center, College of Korean Medicine, 
      Kyung Hee University, Seoul 02447, Republic of Korea.
FAU - Sur, Bongjun
AU  - Sur B
AD  - Acupuncture and Meridian Science Research Center, College of Korean Medicine, 
      Kyung Hee University, Seoul 02447, Republic of Korea.
FAU - Cho, Seong-Guk
AU  - Cho SG
AD  - The Graduate School of Basic Science of Korean Medicine, College of Korean 
      Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
FAU - Yeom, Mijung
AU  - Yeom M
AD  - Acupuncture and Meridian Science Research Center, College of Korean Medicine, 
      Kyung Hee University, Seoul 02447, Republic of Korea.
FAU - Shim, Insop
AU  - Shim I
AD  - Acupuncture and Meridian Science Research Center, College of Korean Medicine, 
      Kyung Hee University, Seoul 02447, Republic of Korea ; The Graduate School of 
      Basic Science of Korean Medicine, College of Korean Medicine, Kyung Hee 
      University, Seoul 02447, Republic of Korea.
FAU - Lee, Hyejung
AU  - Lee H
AD  - Acupuncture and Meridian Science Research Center, College of Korean Medicine, 
      Kyung Hee University, Seoul 02447, Republic of Korea ; The Graduate School of 
      Basic Science of Korean Medicine, College of Korean Medicine, Kyung Hee 
      University, Seoul 02447, Republic of Korea.
FAU - Hahm, Dae-Hyun
AU  - Hahm DH
AD  - Acupuncture and Meridian Science Research Center, College of Korean Medicine, 
      Kyung Hee University, Seoul 02447, Republic of Korea ; The Graduate School of 
      Basic Science of Korean Medicine, College of Korean Medicine, Kyung Hee 
      University, Seoul 02447, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20151101
PL  - Korea (South)
TA  - Biomol Ther (Seoul)
JT  - Biomolecules & therapeutics
JID - 101472832
PMC - PMC4624074
OTO - NOTNLM
OT  - Apoptosis
OT  - Brain-derived neurotrophic factor
OT  - Corticosterone
OT  - Memory
OT  - cAMP-response element-binding protein
OT  - beta-asarone
EDAT- 2015/11/05 06:00
MHDA- 2015/11/05 06:01
PMCR- 2015/11/01
CRDT- 2015/11/05 06:00
PHST- 2015/03/09 00:00 [received]
PHST- 2015/08/11 00:00 [revised]
PHST- 2015/08/12 00:00 [accepted]
PHST- 2015/11/05 06:00 [entrez]
PHST- 2015/11/05 06:00 [pubmed]
PHST- 2015/11/05 06:01 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - bt-23-571 [pii]
AID - 10.4062/biomolther.2015.027 [doi]
PST - ppublish
SO  - Biomol Ther (Seoul). 2015 Nov;23(6):571-81. doi: 10.4062/biomolther.2015.027. 
      Epub 2015 Nov 1.