PMID- 26535709
OWN - NLM
STAT- MEDLINE
DCOM- 20160413
LR  - 20220316
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 4
DP  - 2015 Oct 30
TI  - ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) may not be 
      directly correlated with cardiovascular disease risk.
PG  - 13932-44
LID - 10.4238/2015.October.29.14 [doi]
AB  - The aim of this meta-analysis was to evaluate the correlations between the 
      estrogen receptor 1 (ESR1) gene polymorphisms PvuII (rs2234693T>C) and XbaI 
      (rs9340799A>G) and the risk of cardiovascular disease (CVD). Case-control studies 
      were screened and selected from a larger group of studies that were retrieved 
      through a comprehensive search of scientific literature databases, which was 
      complemented by manual searches. Data from studies selected were analyzed using 
      the Comprehensive Meta-analysis 2.0 software. A total of 240 studies were 
      initially retrieved and 10 studies were eventually included in the meta-analysis. 
      These 10 case-control studies involved 7029 CVD patients (5001 myocardial 
      infarction patients, 1223 coronary artery disease patients, 805 acute coronary 
      syndromes patients) and 6901 healthy controls. We found no significant 
      association between the PvuII (rs2234693T>C) and XbaI (rs9340799A>G) 
      polymorphisms and CVD risk. We detected no significant associations under all 
      genetic inheritance models tested, including the allele, dominant, homozygous, 
      heterozygous, and recessive models, or for comparisons between the case group and 
      control group (all P > 0.05). Our meta-analysis results strongly suggest that the 
      ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) are not 
      associated with CVD risk.
FAU - Jiang, N
AU  - Jiang N
AD  - The Third Department of Cardiovascular, The First Hospital Affiliated 
      Heilongjiang University of TCM, Xiangfang, Harbin, Heilongjiang, China.
FAU - Yang, G
AU  - Yang G
AD  - The Third Department of Cardiovascular, The First Hospital Affiliated 
      Heilongjiang University of TCM, Xiangfang, Harbin, Heilongjiang, China.
FAU - Peng, C L
AU  - Peng CL
AD  - The Third Department of Cardiovascular, The First Hospital Affiliated 
      Heilongjiang University of TCM, Xiangfang, Harbin, Heilongjiang, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20151030
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Alleles
MH  - Cardiovascular Diseases/epidemiology/*genetics
MH  - Case-Control Studies
MH  - Estrogen Receptor alpha/*genetics
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Odds Ratio
MH  - *Polymorphism, Restriction Fragment Length
MH  - Polymorphism, Single Nucleotide
MH  - Publication Bias
MH  - Risk
EDAT- 2015/11/05 06:00
MHDA- 2016/04/14 06:00
CRDT- 2015/11/05 06:00
PHST- 2015/11/05 06:00 [entrez]
PHST- 2015/11/05 06:00 [pubmed]
PHST- 2016/04/14 06:00 [medline]
AID - gmr6121 [pii]
AID - 10.4238/2015.October.29.14 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Oct 30;14(4):13932-44. doi: 10.4238/2015.October.29.14.