PMID- 26535963
OWN - NLM
STAT- MEDLINE
DCOM- 20170907
LR  - 20181113
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 124
IP  - 7
DP  - 2016 Jul
TI  - Sperm Aneuploidy in Faroese Men with Lifetime Exposure to 
      Dichlorodiphenyldichloroethylene (p,p -DDE) and Polychlorinated Biphenyl (PCB) 
      Pollutants.
PG  - 951-6
LID - 10.1289/ehp.1509779 [doi]
AB  - BACKGROUND: Although it is known that sperm aneuploidy contributes to early 
      pregnancy losses and congenital abnormalities, the causes are unknown and 
      environmental contaminants are suspected. OBJECTIVES: Our goal was to evaluate 
      associations between lifetime exposure to organochlorines, specifically 
      dichlorodiphenyldicholorethylene (p,p -DDE) and polychlorinated biphenyls (PCBs), 
      and sperm aneuploidy in men from the general population of the Faroe Islands, a 
      population with a known history of organochlorine exposures. METHODS: Serum and 
      semen samples from men (n = 90) 22-44 years old who participated in Faroe Islands 
      health studies were analyzed for p,p -DDE and PCBs 118, 138, 153, and 180 and 
      adjusted for total lipids. Cord blood and age-14 serum were available for a 
      subgroup (n = 40) and were also analyzed for p,p -DDE and PCBs. Sperm 
      fluorescence in situ hybridization (FISH) for chromosomes X, Y, and 18 was used 
      to determine rates of XX18, XY18, YY18, and total disomy. Multivariable adjusted 
      Poisson models were used to estimate the relationship between organochlorine 
      exposure and sperm disomy outcomes. RESULTS: Adult p,p -DDE and total PCB serum 
      concentrations were both associated with significantly increased rates of XX18, 
      XY18, and total disomy. Age-14 p,p -DDE and PCB concentrations were both 
      associated with significantly increased rates of XX, XY, and total disomy in 
      adulthood. Associations between cord blood concentrations of p,p -DDE and PCBs 
      and sperm disomy in adulthood were not consistently significant. CONCLUSIONS: 
      Organochlorine exposures measured at age 14 and in adulthood were associated with 
      sperm disomy in this sample of high-exposure men, suggesting that the impacts of 
      persistent pollutants on testicular maturation and function require further 
      investigation. CITATION: Perry MJ, Young HA, Grandjean P, Halling J, Petersen MS, 
      Martenies SE, Karimi P, Weihe P. 2016. Sperm aneuploidy in Faroese men with 
      lifetime exposure to dichlorodiphenyldichloroethylene (p,p -DDE) and 
      polychlorinated biphenyl (PCB) pollutants. Environ Health Perspect 
      124:951-956; http://dx.doi.org/10.1289/ehp.1509779.
FAU - Perry, Melissa J
AU  - Perry MJ
AD  - Department of Environmental and Occupational Health, Milken Institute School of 
      Public Health, George Washington University, Washington, DC, USA.
FAU - Young, Heather A
AU  - Young HA
FAU - Grandjean, Philippe
AU  - Grandjean P
FAU - Halling, Jonrit
AU  - Halling J
FAU - Petersen, Maria Skaalum
AU  - Petersen MS
FAU - Martenies, Sheena E
AU  - Martenies SE
FAU - Karimi, Parisa
AU  - Karimi P
FAU - Weihe, Pal
AU  - Weihe P
LA  - eng
GR  - P30 ES000002/ES/NIEHS NIH HHS/United States
GR  - R01 ES009718/ES/NIEHS NIH HHS/United States
GR  - R01 ES014460/ES/NIEHS NIH HHS/United States
GR  - R01 ES017457/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151104
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Environmental Pollutants)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - *Aneuploidy
MH  - Denmark
MH  - Dichlorodiphenyl Dichloroethylene/*blood
MH  - Environmental Exposure/*statistics & numerical data
MH  - Environmental Pollutants/*blood
MH  - Humans
MH  - Male
MH  - Polychlorinated Biphenyls/*blood
MH  - Spermatozoa/drug effects/*pathology
PMC - PMC4937854
COIS- The authors of this paper declare they have no actual or potential competing 
      financial interest and that their freedom to design, conduct, interpret, and 
      publish research was not compromised by any controlling sponsor as a condition of 
      review or publication.
EDAT- 2015/11/05 06:00
MHDA- 2017/09/08 06:00
PMCR- 2016/07/01
CRDT- 2015/11/05 06:00
PHST- 2015/02/02 00:00 [received]
PHST- 2015/10/09 00:00 [accepted]
PHST- 2015/11/05 06:00 [entrez]
PHST- 2015/11/05 06:00 [pubmed]
PHST- 2017/09/08 06:00 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - ehp.1509779 [pii]
AID - 10.1289/ehp.1509779 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2016 Jul;124(7):951-6. doi: 10.1289/ehp.1509779. Epub 
      2015 Nov 4.