PMID- 26535988
OWN - NLM
STAT- MEDLINE
DCOM- 20171227
LR  - 20190107
IS  - 1537-453X (Electronic)
IS  - 0277-3732 (Print)
IS  - 0277-3732 (Linking)
VI  - 41
IP  - 1
DP  - 2018 Jan
TI  - Prognostic Factors as a Function of Disease-free Interval After Definitive 
      (Chemo)radiation for Non-Small Cell Lung Cancer Using Conditional Survival 
      Analysis.
PG  - 46-52
LID - 10.1097/COC.0000000000000235 [doi]
AB  - PURPOSE: We analyzed overall and disease-free survival (OS and DFS) after 
      definitive (chemo)radiation for stage III non-small cell lung cancer with 2 
      statistical methods: Kaplan-Meier (KM) analysis, with diagnosis as index date, 
      and conditional survival (CS) analysis, with a variety of disease-free index 
      dates, and determined whether prognostic factors varied based on the reference 
      date. MATERIALS AND METHODS: All 651 patients analyzed received definitive 
      (chemo)radiotherapy for stage III non-small cell lung cancer in November 1998 to 
      December 2010 at a single institution; all had Karnofsky performance status 
      scores >/=60 and received >/=60 Gy. OS and DFS were first calculated with the KM 
      method, and then CS was used to calculate 2 outcomes: OS conditioned on DFS time 
      (OS|DFS) and DFS conditioned on DFS time (DFS|DFS). Factors predicting OS and DFS 
      conditioned on 1-, 2-, and 3-year DFS were sought in univariate and multivariate 
      analyses. RESULTS: KM analysis produced 1-, 2-, and 3-year DFS rates of 48%, 30%, 
      and 26%; OS rates were 64%, 41%, and 29%. By CS analysis, both OS|DFS and DFS|DFS 
      showed an increase in 5-year OS after 6 months, and CS after 30 months approached 
      100%. On multivariate analyses, age and concurrent chemoradiation predicted 
      OS|DFS; age, smoking history, tumor histology, disease stage, and radiation dose 
      predicted DFS|DFS. CONCLUSIONS: CS analysis showed that the probability of 
      long-term survival increases sharply after 6 months with no evidence of disease; 
      factors predicting survival differed based on the method and endpoint used.
FAU - Hong, Jidong
AU  - Hong J
AD  - Departments of Radiation Oncology.
FAU - Liao, Zhongxing
AU  - Liao Z
AD  - Departments of Radiation Oncology.
FAU - Zhuang, Yan
AU  - Zhuang Y
AD  - Departments of Radiation Oncology.
FAU - Levy, Lawrence B
AU  - Levy LB
AD  - Departments of Radiation Oncology.
FAU - Sheu, Tommy
AU  - Sheu T
AD  - Departments of Radiation Oncology.
FAU - Heymach, John V
AU  - Heymach JV
AD  - Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer 
      Center, Houston, TX.
FAU - Nguyen, Quynh-Nhu
AU  - Nguyen QN
AD  - Departments of Radiation Oncology.
FAU - Xu, Ting
AU  - Xu T
AD  - Departments of Radiation Oncology.
FAU - Komaki, Ritsuko
AU  - Komaki R
AD  - Departments of Radiation Oncology.
FAU - Gomez, Daniel R
AU  - Gomez DR
AD  - Departments of Radiation Oncology.
LA  - eng
GR  - P30 CA016672/CA/NCI NIH HHS/United States
GR  - R01 CA168484/CA/NCI NIH HHS/United States
GR  - R01 CA205150/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Clin Oncol
JT  - American journal of clinical oncology
JID - 8207754
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/*mortality/pathology/*therapy
MH  - *Cause of Death
MH  - Chemoradiotherapy/*methods/mortality
MH  - Cohort Studies
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Karnofsky Performance Status
MH  - Lung Neoplasms/*mortality/pathology/*therapy
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Invasiveness/pathology
MH  - Neoplasm Staging
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Survival Analysis
PMC - PMC4854821
MID - NIHMS722933
COIS- Conflicts of Interest: None
EDAT- 2015/11/05 06:00
MHDA- 2017/12/28 06:00
PMCR- 2019/01/01
CRDT- 2015/11/05 06:00
PHST- 2015/11/05 06:00 [pubmed]
PHST- 2017/12/28 06:00 [medline]
PHST- 2015/11/05 06:00 [entrez]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.1097/COC.0000000000000235 [doi]
PST - ppublish
SO  - Am J Clin Oncol. 2018 Jan;41(1):46-52. doi: 10.1097/COC.0000000000000235.