PMID- 26536170
OWN - NLM
STAT- MEDLINE
DCOM- 20160930
LR  - 20151229
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 120
DP  - 2016 Jan
TI  - Neonatal BCG vaccination of mice improves neurogenesis and behavior in early 
      life.
PG  - 25-33
LID - S0361-9230(15)30051-4 [pii]
LID - 10.1016/j.brainresbull.2015.10.012 [doi]
AB  - Bacillus Calmette-Guerin (BCG) is administered to neonates worldwide, but it is 
      still unknown whether this neonatal vaccination affects brain development during 
      early postnatal life, despite the close association of the immune system with the 
      brain. Newborn C57BL/6 mice were injected subcutaneously with BCG or 
      phosphate-buffered saline (PBS) and their mood status and spatial cognition were 
      observed at four and eight weeks (w) old. The mice were also subjected to tests 
      at 2 and 6 w to examine BCG's effects on neurogenesis, the hippocampal microglia 
      phenotype and number, and the expression of hippocampal neuroimmune molecules and 
      peripheral cytokines. The BCG-injected mice showed better behavioral performances 
      at 4 w. We observed elevated neurogenesis, M2 microglial activation and a 
      neurotrophic profile of neuroimmune molecules [more interferon (IFN)-gamma, 
      interleukin (IL)-4, transforming growth factor (TGF)-beta, brain-derived 
      neurotrophic factor (BDNF) and insulin-like growth factor (IGF)-1 and less tumor 
      necrosis factor (TNF)-alpha and IL-1beta] in the hippocampus of the 2-w-old BCG-mice. In 
      the periphery, BCG induced a T helper (Th)-1 serum response. At the individual 
      level, there were positive correlations between the serum IFN-gamma/IL-4 ratio and 
      the levels of neurotrophins and neurogenesis in the hippocampus. These findings 
      suggest that neonatal BCG vaccination improved neurogenesis and mouse behavior in 
      early life by affecting the neuroimmune milieu in the brain, which may be 
      associated with a systemic Th1 bias.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Yang, Junhua
AU  - Yang J
AD  - Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen 
      University, #74, Zhongshan No. 2 Road, Guangzhou 510080, PR China.
FAU - Qi, Fangfang
AU  - Qi F
AD  - Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen 
      University, #74, Zhongshan No. 2 Road, Guangzhou 510080, PR China.
FAU - Gu, Huaiyu
AU  - Gu H
AD  - Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen 
      University, #74, Zhongshan No. 2 Road, Guangzhou 510080, PR China.
FAU - Zou, Juntao
AU  - Zou J
AD  - Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen 
      University, #74, Zhongshan No. 2 Road, Guangzhou 510080, PR China.
FAU - Yang, Yang
AU  - Yang Y
AD  - Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen 
      University, #74, Zhongshan No. 2 Road, Guangzhou 510080, PR China.
FAU - Yuan, Qunfang
AU  - Yuan Q
AD  - Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen 
      University, #74, Zhongshan No. 2 Road, Guangzhou 510080, PR China.
FAU - Yao, Zhibin
AU  - Yao Z
AD  - Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-Sen 
      University, #74, Zhongshan No. 2 Road, Guangzhou 510080, PR China. Electronic 
      address: yao.zb@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151101
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (BCG Vaccine)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Hand1 protein, mouse)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Anxiety Disorders/immunology/prevention & control
MH  - *BCG Vaccine
MH  - Basic Helix-Loop-Helix Transcription Factors/blood
MH  - Female
MH  - Hippocampus/cytology/*immunology
MH  - Interferon-gamma/blood
MH  - Interleukin-4
MH  - Male
MH  - Maze Learning
MH  - Microglia/cytology/*immunology
MH  - Motor Activity/immunology
MH  - Neurogenesis/*immunology
MH  - Spatial Memory
OTO - NOTNLM
OT  - Cytokine
OT  - Hippocampus
OT  - Microglia
OT  - Neurotrophin
OT  - Th bias
OT  - Vaccine
EDAT- 2015/11/05 06:00
MHDA- 2016/10/01 06:00
CRDT- 2015/11/05 06:00
PHST- 2015/08/26 00:00 [received]
PHST- 2015/10/14 00:00 [revised]
PHST- 2015/10/27 00:00 [accepted]
PHST- 2015/11/05 06:00 [entrez]
PHST- 2015/11/05 06:00 [pubmed]
PHST- 2016/10/01 06:00 [medline]
AID - S0361-9230(15)30051-4 [pii]
AID - 10.1016/j.brainresbull.2015.10.012 [doi]
PST - ppublish
SO  - Brain Res Bull. 2016 Jan;120:25-33. doi: 10.1016/j.brainresbull.2015.10.012. Epub 
      2015 Nov 1.