PMID- 26537778 OWN - NLM STAT- MEDLINE DCOM- 20160719 LR - 20181113 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 16 DP - 2015 Nov 4 TI - Reevaluation for clinical manifestations of HTLV-I-seropositive patients with Sjogren's syndrome. PG - 335 LID - 10.1186/s12891-015-0773-1 [doi] LID - 335 AB - BACKGROUND: The aim of the study was to reassess the prevalence and characteristics of human T lymphotropic virus type I (HTLV-I)-associated Sjogren's syndrome (SS) and SS in HTLV-I-associated myelopathy (HAM) based on the American European Consensus Group (AECG) criteria in HTLV-I endemic area, Nagasaki prefecture. METHODS: The 349 patients who underwent a minor salivary gland biopsy (MSGB) for suspected SS were retrospectively classified by AECG classification criteria and divided with or without anti-HTLV-I antibody. RESULTS: The HTLV-I data-available 294 patients were investigated. One hundred-seventy patients were classified as SS and 26.5 % were HTLV-I-seropositive. We have included 26 patients with HTLV-I-associated myelopathy (HAM) and 38.5 % were classified as having SS. The prevalences of ANA and anti-SS-A/Ro antibody of HAM + SS were significantly low compared to the HTLV-I asymptomatic carriers (AC) with SS and the HTLV-I-seronegative SS patients, although lacrimal dysfunction tended to be high in HAM + SS and significantly high in AC + SS patients compared with the patients with HTLV-I-seronegative SS. The focus scores of MSGB in the HAM + SS patients were similar to those of the AC + SS patients and the HTLV-I-seronegative patients with SS. Among the MSGB-positive patients, there was a low prevalence of ANA in the HAM + SS patients. Similar results were obtained in case of anti-SS-A/Ro or SS-B/La antibody. CONCLUSION: In HTLV-I endemic area, high prevalence of anti-HTLV-I antibody among SS as well as the characteristics of HAM + SS and AC + SS was still determined by AECG classification criteria. FAU - Nakamura, Hideki AU - Nakamura H AD - Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan. nakamura_hideki911@yahoo.co.jp. FAU - Shimizu, Toshimasa AU - Shimizu T AD - Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan. toshimasashimizu2000@yahoo.co.jp. FAU - Takagi, Yukinori AU - Takagi Y AD - Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, Nagasaki, Japan. yuki@nagasaki-u.ac.jp. FAU - Takahashi, Yoshiko AU - Takahashi Y AD - Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan. yoshiko.t.203-10-20@ezweb.ne.jp. FAU - Horai, Yoshiro AU - Horai Y AD - Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan. yoshirohorai0518@yahoo.co.jp. FAU - Nakashima, Yoshikazu AU - Nakashima Y AD - Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan. nakayoshi.1976@gmail.com. FAU - Sato, Shuntaro AU - Sato S AD - Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan. shuntarosato@nagasaki-u.ac.jp. FAU - Shiraishi, Hirokazu AU - Shiraishi H AD - Unit of Translational Medicine, Department of Clinical Neuroscience and Neurology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. hiroshiraishi@nagasaki-u.ac.jp. FAU - Nakamura, Tatsufumi AU - Nakamura T AD - Department of Human Community, Faculty of Social Welfare, Nagasaki International University, Nagasaki, Japan. tatsu@niu.ac.jp. FAU - Fukuoka, Junya AU - Fukuoka J AD - Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan. fukuokaj@nagasaki-u.ac.jp. FAU - Nakamura, Takashi AU - Nakamura T AD - Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, Nagasaki, Japan. taku@nagasaki-u.ac.jp. FAU - Kawakami, Atsushi AU - Kawakami A AD - Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan. atsushik@nagasaki-u.ac.jp. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20151104 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 SB - IM MH - Aged MH - Female MH - HTLV-I Infections/*complications MH - Humans MH - Japan/epidemiology MH - Male MH - Middle Aged MH - Paraparesis, Tropical Spastic/complications MH - Prevalence MH - Retrospective Studies MH - Salivary Glands, Minor/immunology MH - Sjogren's Syndrome/epidemiology/immunology/*virology PMC - PMC4634153 EDAT- 2015/11/06 06:00 MHDA- 2016/07/20 06:00 PMCR- 2015/11/04 CRDT- 2015/11/06 06:00 PHST- 2015/06/16 00:00 [received] PHST- 2015/10/14 00:00 [accepted] PHST- 2015/11/06 06:00 [entrez] PHST- 2015/11/06 06:00 [pubmed] PHST- 2016/07/20 06:00 [medline] PHST- 2015/11/04 00:00 [pmc-release] AID - 10.1186/s12891-015-0773-1 [pii] AID - 773 [pii] AID - 10.1186/s12891-015-0773-1 [doi] PST - epublish SO - BMC Musculoskelet Disord. 2015 Nov 4;16:335. doi: 10.1186/s12891-015-0773-1.