PMID- 26538834
OWN - NLM
STAT- MEDLINE
DCOM- 20160815
LR  - 20200306
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2015
DP  - 2015
TI  - Therapeutic Effect of Chenodeoxycholic Acid in an Experimental Rabbit Model of 
      Osteoarthritis.
PG  - 780149
LID - 10.1155/2015/780149 [doi]
LID - 780149
AB  - Osteoarthritis (OA) is a slowly progressive joint disease typically seen in 
      middle-age to elderly people. At present, there is no ideal agent to treat OA. 
      Chenodeoxycholic acid (CDCA) was a principal active constituent from animal bile. 
      However, the therapeutic effect of CDCA on OA severity was largely unknown. The 
      purpose of this study was to evaluate the therapeutic effect of intra-articular 
      injection of CDCA in a rabbit OA model. OA was induced in experimental rabbits by 
      anterior cruciate ligament transection (ACLT) and then rabbits were 
      intra-articularly injected with CDCA (10 mg/kg or 50 mg/kg) once per week for 5 
      weeks. The results showed that CDCA significantly decreased cartilage degradation 
      on the surface of femoral condyles, reducing the pathological changes of 
      articular cartilage and synovial membrane by macroscopic and histological 
      analysis. CDCA also significantly decreased bone destruction and erosion of joint 
      evaluated by micro-CT. Furthermore, CDCA could markedly reduce the release of 
      matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-3 (MMP-3), 
      interleukin-1beta (IL-1beta), and prostaglandin E2 (PGE2) in synovial fluid. These 
      observations highlight CDCA might be a potential therapeutic agent for OA.
FAU - Yan, Zhao-wei
AU  - Yan ZW
AD  - Department of Clinical Pharmacology, The First Affiliated Hospital of Soochow 
      University, Suzhou, Jiangsu 215006, China.
FAU - Dong, Ji
AU  - Dong J
AD  - Department of Clinical Pharmacology, The First Affiliated Hospital of Soochow 
      University, Suzhou, Jiangsu 215006, China.
FAU - Qin, Chen-hao
AU  - Qin CH
AD  - Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow 
      University, Suzhou, Jiangsu 215004, China.
FAU - Zhao, Chun-yang
AU  - Zhao CY
AD  - Department of Radiology, The Second Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu 215004, China.
FAU - Miao, Li-yan
AU  - Miao LY
AD  - Department of Clinical Pharmacology, The First Affiliated Hospital of Soochow 
      University, Suzhou, Jiangsu 215006, China.
FAU - He, Chun-yan
AU  - He CY
AD  - Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow 
      University, Suzhou, Jiangsu 215004, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151011
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Interleukin-1beta)
RN  - 0 (Prostaglandins E)
RN  - 0GEI24LG0J (Chenodeoxycholic Acid)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
SB  - IM
MH  - Animals
MH  - Anterior Cruciate Ligament/surgery
MH  - Cartilage, Articular/pathology
MH  - Chenodeoxycholic Acid/*therapeutic use
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Femur/pathology
MH  - Injections, Intra-Articular
MH  - Interleukin-1beta/metabolism
MH  - Male
MH  - Matrix Metalloproteinase 1/metabolism
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Osteoarthritis/*drug therapy
MH  - Prostaglandins E/metabolism
MH  - Rabbits
MH  - Synovial Membrane/pathology
MH  - X-Ray Microtomography
PMC - PMC4619964
EDAT- 2015/11/06 06:00
MHDA- 2016/08/16 06:00
PMCR- 2015/10/11
CRDT- 2015/11/06 06:00
PHST- 2015/02/14 00:00 [received]
PHST- 2015/03/18 00:00 [accepted]
PHST- 2015/11/06 06:00 [entrez]
PHST- 2015/11/06 06:00 [pubmed]
PHST- 2016/08/16 06:00 [medline]
PHST- 2015/10/11 00:00 [pmc-release]
AID - 10.1155/2015/780149 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2015;2015:780149. doi: 10.1155/2015/780149. Epub 2015 Oct 11.