PMID- 26538851
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151105
LR  - 20200930
IS  - 0972-2327 (Print)
IS  - 1998-3549 (Electronic)
IS  - 0972-2327 (Linking)
VI  - 18
IP  - Suppl 1
DP  - 2015 Sep
TI  - Epidemiology and genetic aspects of multiple sclerosis in India.
PG  - S6-S10
LID - 10.4103/0972-2327.164814 [doi]
AB  - Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the 
      central nervous system with a complex pathophysiology. Considered a rare disease 
      in India in the past, studies over time suggest an increase in subjects with MS 
      in India, although the observations are limited by the lack of formally conducted 
      epidemiological studies and the absence of a nationwide registry. The current 
      World Health Organization (WHO) Multiple Sclerosis International Federation 
      (MSIF) "Atlas of MS" 2013 estimates a prevalence rate of 5-20 per 100,000, which 
      also seems an underestimate. Although there have been reports of phenotypic 
      differences between MS in Indians and the Western counterparts, recent studies 
      report a reasonable similarity in disease types and characteristics. A few 
      studies on the genetics of MS have been reported, including human leukocyte 
      antigen (HLA) associations and non-major histopathology complex (MHC) disease 
      loci. The current review discusses the pivotal studies of the past, newer 
      observations on MS from India, and the need for a national registry.
FAU - Bhatia, Rohit
AU  - Bhatia R
AD  - Department of Neurology, Cardiothoracic and Neurosciences Centre, All India 
      Institute of Medical Sciences, New Delhi, India.
FAU - Bali, Prerna
AU  - Bali P
AD  - Department of Neurology, Cardiothoracic and Neurosciences Centre, All India 
      Institute of Medical Sciences, New Delhi, India.
FAU - Chaudhari, Rima M
AU  - Chaudhari RM
AD  - Department of Neurology, Cardiothoracic and Neurosciences Centre, All India 
      Institute of Medical Sciences, New Delhi, India.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Ann Indian Acad Neurol
JT  - Annals of Indian Academy of Neurology
JID - 101273955
PMC - PMC4604700
OTO - NOTNLM
OT  - Epidemiology
OT  - genetic
OT  - multiple sclerosis (MS)
EDAT- 2015/11/06 06:00
MHDA- 2015/11/06 06:01
PMCR- 2015/09/01
CRDT- 2015/11/06 06:00
PHST- 2015/11/06 06:00 [entrez]
PHST- 2015/11/06 06:00 [pubmed]
PHST- 2015/11/06 06:01 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - AIAN-18-6 [pii]
AID - 10.4103/0972-2327.164814 [doi]
PST - ppublish
SO  - Ann Indian Acad Neurol. 2015 Sep;18(Suppl 1):S6-S10. doi: 
      10.4103/0972-2327.164814.