PMID- 26541104
OWN - NLM
STAT- MEDLINE
DCOM- 20160920
LR  - 20220408
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 26
IP  - 3
DP  - 2016 May-Jun
TI  - Anterior corneal surface irregularity after Descemet-stripping endothelial 
      keratoplasty for bullous keratopathy.
PG  - 209-15
LID - 10.5301/ejo.5000698 [doi]
AB  - PURPOSE: To evaluate irregularity of the anterior cornea before and after 
      Descemet stripping endothelial keratoplasty (DSEK) for bullous keratopathy and 
      its effect on visual acuity. METHODS: Corneal data were acquired using a 
      topographic unit before and up to 12 months after DSEK. Anterior corneal 
      elevation data were decomposed into a set of Zernike polynomials up to the 8th 
      order within a 6.0-mm diameter region. Total higher-order aberrations (HOAs) and 
      root mean square from the 3rd to 8th order were calculated. The effects of 
      anterior surface irregularity on visual acuity were evaluated. RESULTS: This 
      clinical study comprised 20 consecutive eyes of 20 patients with bullous 
      keratopathy. The mean corrected distance visual acuity (CDVA) was 1.00 +/- 0.12 
      logMAR (SD) preoperatively and 0.24 +/- 0.16 logMAR 12 months postoperatively. 
      Before DSEK, corneas with bullous keratopathy had higher total HOAs compared with 
      those in controls (p<0.05). There were no significant differences in anterior 
      surface HOAs between preoperatively and 12 months (p>0.05). CONCLUSIONS: 
      Postoperative CDVA correlated with irregularity of the corneal anterior surface. 
      Corneal anterior HOAs are higher in patients with bullous keratopathy than in 
      controls, and remain higher through 12 months after DSEK. In addition to corneal 
      transparency, regularity of the corneal anterior surface is an important factor 
      in visual acuity after DSEK.
FAU - Spadea, Leopoldo
AU  - Spadea L
AD  - Department of Biotechnology and Medical-Surgical Sciences, "Sapienza" University 
      of Rome, Rome - Italy.
FAU - Santamaria, Valentina
AU  - Santamaria V
AD  - Department of Biotechnology and Medical-Surgical Sciences, "Sapienza" University 
      of Rome, Rome - Italy.
FAU - Vingolo, Enzo Maria
AU  - Vingolo EM
AD  - Department of Biotechnology and Medical-Surgical Sciences, "Sapienza" University 
      of Rome, Rome - Italy.
FAU - Cagini, Carlo
AU  - Cagini C
AD  - Department of Surgical and Biomedical Sciences, University of Perugia, Perugia - 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20151028
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anterior Eye Segment/physiopathology
MH  - Astigmatism/*physiopathology
MH  - Cornea/*physiopathology
MH  - Corneal Diseases/*surgery
MH  - Corneal Pachymetry
MH  - Corneal Topography
MH  - Corneal Wavefront Aberration/*physiopathology
MH  - *Descemet Stripping Endothelial Keratoplasty
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Visual Acuity/physiology
EDAT- 2015/11/07 06:00
MHDA- 2016/09/22 06:00
CRDT- 2015/11/07 06:00
PHST- 2015/10/01 00:00 [accepted]
PHST- 2015/11/07 06:00 [entrez]
PHST- 2015/11/07 06:00 [pubmed]
PHST- 2016/09/22 06:00 [medline]
AID - 94D5A9E7-5045-4998-A2F6-151C8A091872 [pii]
AID - 10.5301/ejo.5000698 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2016 May-Jun;26(3):209-15. doi: 10.5301/ejo.5000698. Epub 2015 
      Oct 28.