PMID- 26541352
OWN - NLM
STAT- MEDLINE
DCOM- 20170502
LR  - 20211204
IS  - 1442-2050 (Electronic)
IS  - 1120-8694 (Linking)
VI  - 29
IP  - 8
DP  - 2016 Nov
TI  - Co-occurrence of eosinophilic esophagitis and potential/probable celiac disease 
      in an adult cohort: a possible association with implications for clinical 
      practice.
PG  - 977-982
LID - 10.1111/dote.12419 [doi]
AB  - We describe an adult cohort with eosinophilic esophagitis (EoE) and evidence of 
      celiac disease (CD), propose a change in diagnostic practice to better 
      characterize these conditions, and hypothesize new directions for research. 
      Pediatric studies postulate association between gluten sensitivity and EoE. 
      However, few publications describe the prevalence, detection, or therapeutic and 
      pathophysiologic implications of such association in adults. Retrospective chart 
      review was done on patients diagnosed with EoE from 2009 to 2010 at University of 
      Utah Hospitals and Clinics. Data included sex, age, presentation, duodenal 
      pathology, tissue transglutaminase immunoglobulin A antibody (TTG) positivity, 
      human leukocyte antigen (HLA) type (when indicated), and gross and microscopic 
      Esophagogastroduodenoscopy (EGD) findings. Duodenal biopsy, TTG results, and HLA 
      type were correlated. Endoscopy was repeated after gluten-free diet. Forty-four 
      of 75 patients were followed in EoE specialty clinic with duodenal biopsy and TTG 
      testing per protocol. Six EoE patients had potential or probable CD. No sex or 
      age differences were noted between those with findings of CD and EoE and those 
      with EoE alone. Six patients with findings of CD and EoE followed gluten-free 
      diet. Five underwent repeat endoscopy. Three had resolution of esophageal 
      eosinophilia. Potential or probable CD was commonly found in adults with EoE. 
      Diagnosis of CD may be challenging due to nonspecific symptoms and insufficient 
      duodenal biopsy and serologic testing. Furthermore, gluten-free diet resolved EoE 
      findings in some patients, suggesting possible shared pathophysiology in some 
      cases of EoE and CD. TTG testing and adequate duodenal biopsy may further direct 
      clinical care for EoE patients, and studies are needed to elucidate mechanisms 
      linking EoE and CD.
CI  - (c) 2015 International Society for Diseases of the Esophagus.
FAU - Johnson, J B
AU  - Johnson JB
AD  - Department of Medicine, The Health Sciences Center, University of Utah, Salt Lake 
      City, Utah, USA.
FAU - Boynton, K K
AU  - Boynton KK
AD  - Department of Medicine, The Health Sciences Center, University of Utah, Salt Lake 
      City, Utah, USA.
FAU - Peterson, K A
AU  - Peterson KA
AD  - Department of Medicine, The Health Sciences Center, University of Utah, Salt Lake 
      City, Utah, USA.
LA  - eng
PT  - Journal Article
DEP - 20151106
PL  - United States
TA  - Dis Esophagus
JT  - Diseases of the esophagus : official journal of the International Society for 
      Diseases of the Esophagus
JID - 8809160
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - EC 2.3.2.13 (Protein Glutamine gamma Glutamyltransferase 2)
RN  - EC 2.3.2.13 (Transglutaminases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Celiac Disease/*complications/immunology/pathology
MH  - Cohort Studies
MH  - Duodenum/pathology
MH  - Endoscopy, Digestive System
MH  - Eosinophilic Esophagitis/*complications/pathology/physiopathology
MH  - Female
MH  - GTP-Binding Proteins/immunology
MH  - Humans
MH  - Immunoglobulin A/immunology
MH  - Immunoglobulin G/immunology
MH  - Male
MH  - Middle Aged
MH  - Protein Glutamine gamma Glutamyltransferase 2
MH  - Retrospective Studies
MH  - Transglutaminases/immunology
OTO - NOTNLM
OT  - celiac disease
OT  - celiac sprue
OT  - endoscopy
OT  - eosinophilic esophagitis
OT  - esophageal biopsy
EDAT- 2015/11/07 06:00
MHDA- 2017/05/04 06:00
CRDT- 2015/11/07 06:00
PHST- 2015/11/07 06:00 [pubmed]
PHST- 2017/05/04 06:00 [medline]
PHST- 2015/11/07 06:00 [entrez]
AID - 10.1111/dote.12419 [doi]
PST - ppublish
SO  - Dis Esophagus. 2016 Nov;29(8):977-982. doi: 10.1111/dote.12419. Epub 2015 Nov 6.