PMID- 26542064
OWN - NLM
STAT- MEDLINE
DCOM- 20160810
LR  - 20220330
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 126
IP  - 4
DP  - 2016 Apr
TI  - Detection of human papillomavirus in laryngeal squamous cell carcinoma: 
      Systematic review and meta-analysis.
PG  - 885-93
LID - 10.1002/lary.25738 [doi]
AB  - BACKGROUND: Recent studies have reported a human papillomavirus (HPV) prevalence 
      of 20% to 30% in laryngeal squamous cell carcinoma (LSCC), although clinical data 
      on HPV involvement remain largely inconsistent, ascribed by some to differences 
      in HPV detection methods or in geographic origin of the studies. OBJECTIVE: To 
      perform a systematic review and formal meta-analysis of the literature reporting 
      on HPV detection in LSCC. METHODS: Literature was searched from January 1964 
      until March 2015. The effect size was calculated as event rates (95% confidence 
      interval [CI]), with homogeneity testing using Cochran's Q and I(2) statistics. 
      Meta-regression was used to test the impact of study-level covariates (HPV 
      detection method, geographic origin) on effect size. Potential publication bias 
      was estimated using funnel plot symmetry. RESULTS: One hundred seventy nine 
      studies were eligible, comprising a sample size of 7,347 LSCCs from different 
      geographic regions. Altogether, 1,830 (25%) cases tested HPV-positive considering 
      all methods, with effect size of 0.269 (95% CI: 0.242 to 0.297; random-effects 
      model). In meta-analysis stratified by the 1) HPV detection technique and 2) 
      geographic study origin, the between-study heterogeneity was significant only for 
      geographic origin (P = .0001). In meta-regression, the HPV detection method (P = 
      .876) or geographic origin (P = .234) were not significant study-level 
      covariates. Some evidence for publication bias was found only for studies from 
      North America and those using non-polymerase chain reaction methods, with a 
      marginal effect on adjusted point estimates for both. CONCLUSIONS: Variability in 
      HPV detection rates in LSCC is explained by geographic origin of study but not by 
      HPV detection method. However, they were not significant study-level covariates 
      in formal meta-regression. LEVEL OF EVIDENCE: NA.
CI  - (c) 2015 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Gama, Ricardo Ribeiro
AU  - Gama RR
AD  - Department of Surgical Oncology, Head and Neck Surgery, Barretos Cancer Hospital, 
      Barretos, Brazil.
FAU - Carvalho, Andre Lopes
AU  - Carvalho AL
AD  - Department of Surgical Oncology, Head and Neck Surgery, Barretos Cancer Hospital, 
      Barretos, Brazil.
FAU - Longatto Filho, Adhemar
AU  - Longatto Filho A
AD  - Laboratory of Medical Investigation (LIM) 14, Department of Pathology, University 
      of Sao Paulo School of Medicine, Sao Paulo, Brazil.
AD  - Life and Health Sciences Research Institute, School of Health Sciences, 
      University of Minho, Braga, Portugal.
AD  - ICVS/3B's-PT Government Associate Laboratory, Braga/Guimaraes, Portugal.
AD  - Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.
FAU - Scorsato, Anderson Paulo
AU  - Scorsato AP
AD  - Department of Bioestatistics, Barretos Cancer Hospital, Barretos, Brazil.
FAU - Lopez, Rossana V Mendoza
AU  - Lopez RV
AD  - Oncology Translational Centre, Cancer Institute of Sao Paulo, Sao Paulo, Brazil.
FAU - Rautava, Jaana
AU  - Rautava J
AD  - Department of Oral Pathology and Radiology, Institute of Dentistry, University of 
      Turku, Turku, Finland.
FAU - Syrjanen, Stina
AU  - Syrjanen S
AD  - Department of Oral Pathology and Radiology, Institute of Dentistry, University of 
      Turku, Turku, Finland.
FAU - Syrjanen, Kari
AU  - Syrjanen K
AD  - Department of Clinical Research, Biohit HealthCare Plc, Helsinki, Finland.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20151106
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Carcinoma, Squamous Cell/epidemiology/*virology
MH  - Humans
MH  - Laryngeal Neoplasms/epidemiology/*virology
MH  - Papillomaviridae/*isolation & purification
MH  - Papillomavirus Infections/*complications/epidemiology
OTO - NOTNLM
OT  - Laryngeal cancer
OT  - detection method
OT  - geographic region
OT  - meta-analysis
OT  - meta-regression
OT  - papillomavirus
OT  - publication bias
OT  - study heterogeneity
EDAT- 2015/11/07 06:00
MHDA- 2016/08/11 06:00
CRDT- 2015/11/07 06:00
PHST- 2015/09/22 00:00 [accepted]
PHST- 2015/11/07 06:00 [entrez]
PHST- 2015/11/07 06:00 [pubmed]
PHST- 2016/08/11 06:00 [medline]
AID - 10.1002/lary.25738 [doi]
PST - ppublish
SO  - Laryngoscope. 2016 Apr;126(4):885-93. doi: 10.1002/lary.25738. Epub 2015 Nov 6.