PMID- 26543876
OWN - NLM
STAT- MEDLINE
DCOM- 20160819
LR  - 20181113
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2015
DP  - 2015
TI  - Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second 
      Signal Blockage.
PG  - 856707
LID - 10.1155/2015/856707 [doi]
LID - 856707
AB  - Dendritic cells (DCs), the most important professional antigen-presenting cells 
      (APC), play crucial role in both immunity and tolerance. It is well known that 
      DCs are able to mount immune responses against foreign antigens and 
      simultaneously tolerate self-antigens. Since DCs can be modulated depending on 
      the surrounding microenvironment, they can act as a bridge between innate and 
      adaptive immunity. However, the mechanisms that support this dual role are not 
      entirely clear. Recent studies have shown that DCs can be manipulated ex vivo in 
      order to trigger their tolerogenic profile, what can be a tool to be used in 
      clinical trials aiming the treatment of various diseases and the prevention of 
      transplant rejection. In this sense, the blockage of costimulatory molecules on 
      DC, in the attempt of inhibiting the second signal in the immunological synapse, 
      can be considered as one of the main strategies under development. This review 
      brings an update on current therapies using tolerogenic dendritic cells modulated 
      with costimulatory blockers with the aim of reducing transplant rejection. 
      However, although there are current clinical trials using tolerogenic DC to treat 
      allograft rejection, the actual challenge is to modulate these cells in order to 
      maintain a permanent tolerogenic profile.
FAU - Silva, Priscila de Matos
AU  - Silva Pde M
AD  - Department of Biomedical Science, Faculty of Americana (FAM), 13477-360 
      Americana, SP, Brazil ; Medical School, University of Campinas (UNICAMP), 
      13083-887 Campinas, SP, Brazil.
FAU - Bier, Julia
AU  - Bier J
AD  - Department of Genetics, Evolution and Bioagents, Institute of Biology, University 
      of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
FAU - Paiatto, Lisiery Negrini
AU  - Paiatto LN
AD  - Department of Biomedical Science, Faculty of Americana (FAM), 13477-360 
      Americana, SP, Brazil ; Department of Genetics, Evolution and Bioagents, 
      Institute of Biology, University of Campinas (UNICAMP), 13083-970 Campinas, SP, 
      Brazil.
FAU - Galdino Albuquerque, Cassia
AU  - Galdino Albuquerque C
AD  - Department of Genetics, Evolution and Bioagents, Institute of Biology, University 
      of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
FAU - Lopes Souza, Caique
AU  - Lopes Souza C
AD  - Department of Genetics, Evolution and Bioagents, Institute of Biology, University 
      of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
FAU - Fernandes, Luis Gustavo Romani
AU  - Fernandes LG
AD  - Department of Biomedical Science, Faculty of Americana (FAM), 13477-360 
      Americana, SP, Brazil ; Medical School, University of Campinas (UNICAMP), 
      13083-887 Campinas, SP, Brazil.
FAU - Tamashiro, Wirla Maria da Silva Cunha
AU  - Tamashiro WM
AD  - Department of Genetics, Evolution and Bioagents, Institute of Biology, University 
      of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
FAU - Simioni, Patricia Ucelli
AU  - Simioni PU
AD  - Department of Biomedical Science, Faculty of Americana (FAM), 13477-360 
      Americana, SP, Brazil ; Department of Genetics, Evolution and Bioagents, 
      Institute of Biology, University of Campinas (UNICAMP), 13083-970 Campinas, SP, 
      Brazil ; Department of Biochemistry and Microbiology, Institute of Biosciences, 
      Universidade Estadual Paulista (UNESP), 13506-900 Rio Claro, SP, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151012
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Cell Communication/immunology
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Graft Rejection/immunology/therapy
MH  - Humans
MH  - *Immune Tolerance
MH  - Immunity, Innate
MH  - Immunotherapy
MH  - Signal Transduction
MH  - T-Lymphocyte Subsets/immunology/metabolism
MH  - *Transplantation Immunology
MH  - Transplantation, Homologous
PMC - PMC4620289
EDAT- 2015/11/07 06:00
MHDA- 2016/08/20 06:00
PMCR- 2015/10/12
CRDT- 2015/11/07 06:00
PHST- 2015/04/24 00:00 [received]
PHST- 2015/06/23 00:00 [revised]
PHST- 2015/06/29 00:00 [accepted]
PHST- 2015/11/07 06:00 [entrez]
PHST- 2015/11/07 06:00 [pubmed]
PHST- 2016/08/20 06:00 [medline]
PHST- 2015/10/12 00:00 [pmc-release]
AID - 10.1155/2015/856707 [doi]
PST - ppublish
SO  - J Immunol Res. 2015;2015:856707. doi: 10.1155/2015/856707. Epub 2015 Oct 12.