PMID- 26544669
OWN - NLM
STAT- MEDLINE
DCOM- 20160718
LR  - 20160216
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 63
IP  - 4
DP  - 2016 Apr
TI  - Loss of Mismatched HLA on the Leukemic Blasts of Patients With Relapsed Lymphoid 
      Malignancies Following Bone Marrow Transplantation From Related Donors With HLA 
      Class II Mismatches in the Graft Versus Host Direction.
PG  - 709-11
LID - 10.1002/pbc.25819 [doi]
AB  - Mechanisms of relapse of acute lymphoblastic leukemia (ALL) after human leukocyte 
      antigen (HLA) class II mismatched hematopoietic stem cell transplantation (HSCT) 
      remain unclear. We report two children with relapsed ALL after HSCT from related 
      donors with HLA-DRB1 and -DQB1 mismatches in the graft versus host direction. One 
      lost HLA-DRB1, DQB1, and DPB1 alleles, and the other lost one HLA haplotype of 
      the leukemic blasts at relapse. HLA class II loss may be a triggering event for 
      ALL relapse after partially HLA-mismatched-related HSCT. In addition, HLA typing 
      of relapsed leukemic blasts could be vital in the selection of retransplant 
      donors.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Hirabayashi, Koichi
AU  - Hirabayashi K
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Kurata, Takashi
AU  - Kurata T
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Horiuchi, Kazuki
AU  - Horiuchi K
AD  - Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan.
FAU - Saito, Shoji
AU  - Saito S
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Shigemura, Tomonari
AU  - Shigemura T
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Tanaka, Miyuki
AU  - Tanaka M
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Yanagisawa, Ryu
AU  - Yanagisawa R
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Matsuda, Kazuyuki
AU  - Matsuda K
AD  - Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan.
FAU - Sakashita, Kazuo
AU  - Sakashita K
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Koike, Kenichi
AU  - Koike K
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Nakazawa, Yozo
AU  - Nakazawa Y
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20151106
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Alleles
MH  - Child
MH  - Female
MH  - Graft vs Host Disease/*genetics/immunology
MH  - HLA-DP beta-Chains/genetics
MH  - HLA-DQ beta-Chains/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Haplotypes
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Histocompatibility
MH  - Histocompatibility Antigens Class II/*genetics/immunology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Neoplasm Recurrence, Local/*genetics/immunology
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics/immunology/*surgery
OTO - NOTNLM
OT  - HLA class II
OT  - HLA loss
OT  - acute lymphoblastic leukemia
OT  - relapse
OT  - stem cell transplantation
EDAT- 2015/11/07 06:00
MHDA- 2016/07/19 06:00
CRDT- 2015/11/07 06:00
PHST- 2015/05/30 00:00 [received]
PHST- 2015/09/17 00:00 [revised]
PHST- 2015/10/04 00:00 [accepted]
PHST- 2015/11/07 06:00 [entrez]
PHST- 2015/11/07 06:00 [pubmed]
PHST- 2016/07/19 06:00 [medline]
AID - 10.1002/pbc.25819 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2016 Apr;63(4):709-11. doi: 10.1002/pbc.25819. Epub 2015 
      Nov 6.