PMID- 26545308
OWN - NLM
STAT- MEDLINE
DCOM- 20161019
LR  - 20181202
IS  - 1365-2222 (Electronic)
IS  - 0954-7894 (Linking)
VI  - 46
IP  - 2
DP  - 2016 Feb
TI  - Comorbidity and pathogenic links of chronic spontaneous urticaria and systemic 
      lupus erythematosus--a systematic review.
PG  - 275-87
LID - 10.1111/cea.12673 [doi]
AB  - Chronic spontaneous urticaria (CSU) is a common mast cell-driven disease 
      characterized by the development of wheals (hives), angioedema (AE), or both for 
      > 6 weeks. It is thought that autoimmunity is a common cause of CSU, which is 
      often associated with autoimmune thyroiditis, whereas the link to other 
      autoimmune disorders such as systemic lupus erythematosus (SLE) has not been 
      carefully explored. Here, we systematically reviewed the existing literature for 
      information on the prevalence of CSU in SLE (and vice versa) and we examined the 
      possible clinical and pathogenetic relationship between CSU and SLE. The 
      prevalence of CSU and CSU-like rash in SLE was investigated by 42 independent 
      studies and comorbidity in adult patients reportedly ranged from 0% to 21.9% and 
      0.4% to 27.5%, respectively (urticarial vasculitis: 0-20%). In children with SLE, 
      CSU was reported in 0-1.2% and CSU-like rash in 4.5-12% (urticarial vasculitis: 
      0-2.2%). In contrast, little information is available on the prevalence of SLE in 
      patients with CSU, and more studies are needed to determine the rate of 
      comorbidity. Recent insights on IgG- and IgE-mediated autoreactivity suggest 
      similarities in the pathogenesis of CSU and SLE linking inflammation and 
      autoimmunity with the activation of the complement and coagulation system. Future 
      studies of patients with either or both conditions could help to better define 
      common pathomechanisms in CSU and SLE and to develop novel targeted treatment 
      options for patients with CSU and SLE.
CI  - (c) 2015 John Wiley & Sons Ltd.
FAU - Kolkhir, P
AU  - Kolkhir P
AD  - Department of Dermatology and Venereology, Sechenov First Moscow State Medical 
      University, Moscow, Russia.
FAU - Pogorelov, D
AU  - Pogorelov D
AD  - Department of Dermatology and Venereology, Sechenov First Moscow State Medical 
      University, Moscow, Russia.
FAU - Olisova, O
AU  - Olisova O
AD  - Department of Dermatology and Venereology, Sechenov First Moscow State Medical 
      University, Moscow, Russia.
FAU - Maurer, M
AU  - Maurer M
AD  - Department of Dermatology and Allergy, Charite-Universitatsmedizin Berlin, 
      Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
SB  - IM
MH  - Chronic Disease
MH  - Comorbidity
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*complications/*epidemiology
MH  - Prevalence
MH  - Urticaria/*complications/*epidemiology
EDAT- 2015/11/08 06:00
MHDA- 2016/11/12 06:00
CRDT- 2015/11/08 06:00
PHST- 2015/11/08 06:00 [entrez]
PHST- 2015/11/08 06:00 [pubmed]
PHST- 2016/11/12 06:00 [medline]
AID - 10.1111/cea.12673 [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2016 Feb;46(2):275-87. doi: 10.1111/cea.12673.