PMID- 26545456
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20220409
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 131
DP  - 2016 May 1
TI  - Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related 
      changes in memory, hippocampal perfusion and volumes in older adults.
PG  - 142-54
LID - S1053-8119(15)01015-0 [pii]
LID - 10.1016/j.neuroimage.2015.10.084 [doi]
AB  - Animal models point towards a key role of brain-derived neurotrophic factor 
      (BDNF), insulin-like growth factor-I (IGF-I) and vascular endothelial growth 
      factor (VEGF) in mediating exercise-induced structural and functional changes in 
      the hippocampus. Recently, also platelet derived growth factor-C (PDGF-C) has 
      been shown to promote blood vessel growth and neuronal survival. Moreover, 
      reductions of these neurotrophic and angiogenic factors in old age have been 
      related to hippocampal atrophy, decreased vascularization and cognitive decline. 
      In a 3-month aerobic exercise study, forty healthy older humans (60 to 77years) 
      were pseudo-randomly assigned to either an aerobic exercise group (indoor 
      treadmill, n=21) or to a control group (indoor progressive-muscle 
      relaxation/stretching, n=19). As reported recently, we found evidence for 
      fitness-related perfusion changes of the aged human hippocampus that were closely 
      linked to changes in episodic memory function. Here, we test whether peripheral 
      levels of BDNF, IGF-I, VEGF or PDGF-C are related to changes in hippocampal blood 
      flow, volume and memory performance. Growth factor levels were not significantly 
      affected by exercise, and their changes were not related to changes in fitness or 
      perfusion. However, changes in IGF-I levels were positively correlated with 
      hippocampal volume changes (derived by manual volumetry and voxel-based 
      morphometry) and late verbal recall performance, a relationship that seemed to be 
      independent of fitness, perfusion or their changes over time. These preliminary 
      findings link IGF-I levels to hippocampal volume changes and putatively 
      hippocampus-dependent memory changes that seem to occur over time independently 
      of exercise. We discuss methodological shortcomings of our study and potential 
      differences in the temporal dynamics of how IGF-1, VEGF and BDNF may be affected 
      by exercise and to what extent these differences may have led to the negative 
      findings reported here.
CI  - Copyright (c) 2015 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Maass, Anne
AU  - Maass A
AD  - Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke 
      University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany; German Center 
      for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120 Magdeburg, 
      Germany. Electronic address: anne.maass@med.ovgu.de.
FAU - Duzel, Sandra
AU  - Duzel S
AD  - Center for Lifespan Psychology, Max Planck Institute for Human Development, 
      Lentzeallee 94, 14195 Berlin, Germany.
FAU - Brigadski, Tanja
AU  - Brigadski T
AD  - Institute of Physiology, Otto-von-Guericke-University Magdeburg, Leipziger Str. 
      44, 39120 Magdeburg, Germany; Center for Behavioral Brain Sciences, 
      Otto-von-Guericke University Magdeburg, Universitatsplatz 2, 39106 Magdeburg, 
      Germany.
FAU - Goerke, Monique
AU  - Goerke M
AD  - German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120 
      Magdeburg, Germany; Department of Psychiatry and Psychotherapy, University of 
      Rostock, 18147 Rostock, Germany.
FAU - Becke, Andreas
AU  - Becke A
AD  - German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120 
      Magdeburg, Germany.
FAU - Sobieray, Uwe
AU  - Sobieray U
AD  - German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120 
      Magdeburg, Germany.
FAU - Neumann, Katja
AU  - Neumann K
AD  - Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke 
      University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany; German Center 
      for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120 Magdeburg, 
      Germany.
FAU - Lovden, Martin
AU  - Lovden M
AD  - Center for Lifespan Psychology, Max Planck Institute for Human Development, 
      Lentzeallee 94, 14195 Berlin, Germany; Aging Research Center, Karolinska 
      Institutet & Stockholm University, Gavlegatan 16, SE-113 30 Stockholm, Sweden.
FAU - Lindenberger, Ulman
AU  - Lindenberger U
AD  - Center for Lifespan Psychology, Max Planck Institute for Human Development, 
      Lentzeallee 94, 14195 Berlin, Germany; European University Institute, Badia 
      Fiesolana, Via dei Roccettini 9, 50014 San Domenico di Fiesole, Italy; Max Planck 
      UCL Centre for Computational Psychiatry and Ageing Research, Lentzeallee 94, 
      14195 Berlin, Germany.
FAU - Backman, Lars
AU  - Backman L
AD  - Aging Research Center, Karolinska Institutet & Stockholm University, Gavlegatan 
      16, SE-113 30 Stockholm, Sweden.
FAU - Braun-Dullaeus, Rudiger
AU  - Braun-Dullaeus R
AD  - Department of Internal Medicine, Division of Cardiology, Angiology and 
      Pneumology, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 
      Magdeburg, Germany.
FAU - Ahrens, Dorte
AU  - Ahrens D
AD  - Department of Internal Medicine, Division of Cardiology, Angiology and 
      Pneumology, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 
      Magdeburg, Germany.
FAU - Heinze, Hans-Jochen
AU  - Heinze HJ
AD  - German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120 
      Magdeburg, Germany; Center for Behavioral Brain Sciences, Otto-von-Guericke 
      University Magdeburg, Universitatsplatz 2, 39106 Magdeburg, Germany; Department 
      of Neurology, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120 
      Magdeburg, Germany; Leibniz Institute for Neurobiology, Brenneckestr. 6, 39118 
      Magdeburg, Germany.
FAU - Muller, Notger G
AU  - Muller NG
AD  - German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120 
      Magdeburg, Germany.
FAU - Lessmann, Volkmar
AU  - Lessmann V
AD  - Institute of Physiology, Otto-von-Guericke-University Magdeburg, Leipziger Str. 
      44, 39120 Magdeburg, Germany; Center for Behavioral Brain Sciences, 
      Otto-von-Guericke University Magdeburg, Universitatsplatz 2, 39106 Magdeburg, 
      Germany.
FAU - Sendtner, Michael
AU  - Sendtner M
AD  - Institute of Clinical Neurobiology, University Hospital Wuerzburg, Versbacherstr. 
      5, 97078 Wurzburg, Germany.
FAU - Duzel, Emrah
AU  - Duzel E
AD  - Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke 
      University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany; German Center 
      for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120 Magdeburg, 
      Germany; Center for Behavioral Brain Sciences, Otto-von-Guericke University 
      Magdeburg, Universitatsplatz 2, 39106 Magdeburg, Germany; Department of 
      Neurology, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120 
      Magdeburg, Germany; Institute of Cognitive Neuroscience, University College 
      London, 17 Queen Square, London, UK. Electronic address: emrah.duezel@dzne.de.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20151103
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Aging/physiology
MH  - Blood Flow Velocity/physiology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cerebrovascular Circulation/*physiology
MH  - Exercise/*physiology
MH  - Female
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Memory/*physiology
MH  - Middle Aged
MH  - Neuronal Plasticity/physiology
MH  - Organ Size/physiology
MH  - Physical Conditioning, Human/methods
MH  - Physical Fitness/physiology
MH  - Vascular Endothelial Growth Factor A/*blood
OTO - NOTNLM
OT  - Aging
OT  - Exercise
OT  - Hippocampus
OT  - Neurotrophic factors
OT  - Vascular plasticity
EDAT- 2015/11/08 06:00
MHDA- 2018/01/09 06:00
CRDT- 2015/11/08 06:00
PHST- 2015/10/04 00:00 [received]
PHST- 2015/10/25 00:00 [revised]
PHST- 2015/10/29 00:00 [accepted]
PHST- 2015/11/08 06:00 [entrez]
PHST- 2015/11/08 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
AID - S1053-8119(15)01015-0 [pii]
AID - 10.1016/j.neuroimage.2015.10.084 [doi]
PST - ppublish
SO  - Neuroimage. 2016 May 1;131:142-54. doi: 10.1016/j.neuroimage.2015.10.084. Epub 
      2015 Nov 3.