PMID- 26545657
OWN - NLM
STAT- MEDLINE
DCOM- 20170131
LR  - 20170131
IS  - 1699-5198 (Electronic)
IS  - 0212-1611 (Linking)
VI  - 32
IP  - 5
DP  - 2015 Nov 1
TI  - NUTRITIONAL AND METABOLIC ASSESSMENT IN OVERWEIGHT PATIENTS WITH AND WITHOUT 
      HYPERPROLACTINEMIA CAUSED BY PROLACTINOMA.
PG  - 2030-7
LID - 10.3305/nh.2015.32.5.9673 [doi]
AB  - INTRODUCTION: prolactinomas are pituitary adenomas that express and secrete 
      prolactin. These patients are overweight and the mechanisms are being studied. 
      GOALS: assess nutritional and metabolic status of overweight patients with and 
      without hyperprolactinemia caused by prolactinoma and compare them. MATERIALS AND 
      METHODS: cross-sectional study, patients with body mass index (BMI) >/= 25 kg/m2 
      with and without prolactinoma: 1) 20 normoprolactinemic (NPrl) with prolactinoma; 
      2) 23 hyperprolactinemic (HPrl) with prolactinoma; 3) 28 controls without 
      prolactinoma or alterations in prolactin levels. Evaluated through 
      anthropometric, dietetics, and biochemical assessment. RESULTS: of the 71 
      patients evaluated, most were obese women with macroprolactinomas. All three 
      groups had diets with low caloric and monounsaturated fatty acid (MUFA) intake, 
      the NPrl group had low carbohydrate (CHO) intake and high lipid (LIP) and 
      saturated fatty acid (SFA) intake, and the NPrl and HPrl groups had appropriate 
      intake of polyunsaturated fatty acids (PUFA). The HPrl group had elevated total 
      cholesterol. HDL cholesterol was below the recommended threshold for most 
      patients. No statistically significant differences were found in anthropometric 
      and biochemical variables among the groups. CONCLUSIONS: most patients with 
      prolactinomas and controls are obese and metabolically similar regardless of 
      prolactin levels. All groups presented low caloric and MUFA intake. Protein, LIP, 
      SFA, and cholesterol were significantly different among the groups, the NPrl 
      group ingested less amount of protein and greater of fat. Snacking between meals 
      and changes of food consumption on weekends was reported by most patients. This 
      is the first study comparing patients with prolactinomas and controls, both with 
      overweight, regarding food consumption and feeding behavior.
CI  - Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights 
      reserved.
FAU - Breyer Freitas, Bruna
AU  - Breyer Freitas B
AD  - Federal University of Health Sciences of Porto Alegre (UFCSPA).. 
      brunabreyer@hotmail.com.
FAU - Rothen, Renata Elisabeth
AU  - Rothen RE
AD  - Federal University of Health Sciences of Porto Alegre (UFCSPA).. 
      renataer@hotmail.com.
FAU - Zeni, Debora
AU  - Zeni D
AD  - Neuroendocrinology Center of Santa Casa of Porto Alegre, Federal University of 
      Health Sciences of Porto Alegre (UFCSPA), Porto Alegre.. debora_zeni@hotmail.com.
FAU - Garcia Soares Leaes, Carolina
AU  - Garcia Soares Leaes C
AD  - Neuroendocrinology Center of Santa Casa of Porto Alegre, Federal University of 
      Health Sciences of Porto Alegre (UFCSPA), Porto Alegre.. 
      carolinagsleaes@gmail.com.
FAU - Costa Oliveira, Miriam
AU  - Costa Oliveira M
AD  - Federal University of Health Sciences of Porto Alegre (UFCSPA). 
      Neuroendocrinology Center of Santa Casa of Porto Alegre, Federal University of 
      Health Sciences of Porto Alegre (UFCSPA), Porto Alegre.. mco@ufcspa.com.br.
FAU - Michielin Busnello, Fernanda
AU  - Michielin Busnello F
AD  - Department of Nutrition, Federal University of Health Sciences of Porto Alegre 
      (UFCSPA), Porto Alegre, Brazil.. fernandab@ufcspa.edu.br.
FAU - Fernanda Semmelmann Pereira-Lima, Julia
AU  - Fernanda Semmelmann Pereira-Lima J
AD  - Federal University of Health Sciences of Porto Alegre (UFCSPA). 
      Neuroendocrinology Center of Santa Casa of Porto Alegre, Federal University of 
      Health Sciences of Porto Alegre (UFCSPA), Porto Alegre.. 
      jpereiralima@terra.com.br.
LA  - eng
PT  - Journal Article
DEP - 20151101
PL  - Spain
TA  - Nutr Hosp
JT  - Nutricion hospitalaria
JID - 9100365
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diet
MH  - Eating
MH  - Feeding Behavior
MH  - Female
MH  - Humans
MH  - Hyperprolactinemia/*etiology/*metabolism
MH  - Male
MH  - Middle Aged
MH  - *Nutrition Assessment
MH  - Nutritional Status
MH  - Obesity/etiology/metabolism
MH  - Overweight/*complications/*metabolism
MH  - Pituitary Neoplasms/*complications/*metabolism
MH  - Prolactinoma/*complications/*metabolism
EDAT- 2015/11/08 06:00
MHDA- 2017/02/01 06:00
CRDT- 2015/11/08 06:00
PHST- 2015/11/08 06:00 [entrez]
PHST- 2015/11/08 06:00 [pubmed]
PHST- 2017/02/01 06:00 [medline]
AID - 10.3305/nh.2015.32.5.9673 [doi]
PST - epublish
SO  - Nutr Hosp. 2015 Nov 1;32(5):2030-7. doi: 10.3305/nh.2015.32.5.9673.