PMID- 26546899
OWN - NLM
STAT- MEDLINE
DCOM- 20160512
LR  - 20151108
IS  - 1735-1502 (Print)
IS  - 1735-1502 (Linking)
VI  - 14
IP  - 3
DP  - 2015 Jun
TI  - Evaluation of Soluble Human Leukocyte Antigen-G (sHLA-G) Isoforms and Regulatory 
      T Cells in Relapsing-Remitting Multiple Sclerosis.
PG  - 298-305
AB  - Soluble forms of nonclassical human leukocyte antigen (HLA)-G have recently been 
      suggested as immunomodulatory factors in multiple sclerosis (MS). HLA-G inhibits 
      the effecter function of T cells and natural killer (NK) cells. Also regulatory T 
      cells (Treg) are considered as pivotal players in MS pathogenesis. Thus, we aimed 
      to evaluate the presence of HLA-G molecules and Treg cells in Relapsing-Remitting 
      Multiple Sclerosis (RRMS) patients and compare it to healthy controls. Patients 
      with RRMS (n=205, mean age=31.32+/-8.53) and healthy subjects (n=205, mean 
      age=32.2+/-7.48) were studied. The patients subgrouped to untreated and treated 
      with Interferon beta. Then sHLA-G levels (sHLA-G1 and sHLA-G5) were measured 
      using ELISA method. Treg (CD4+ CD25+ Foxp3+) cells in patients who had sHLA-G>10 
      U/ml were characterized by using flow cytometry. Our data showed that there was 
      no significant differences between RRMS patients and healthy controls in sHLA-G 
      concentration (p>0.05). Treg cell frequencies were higher in the patients who had 
      sHLA-G >10 U/ml compared to healthy subjects (p<0.05). Collectively, there was 
      significant correlation between sHLA-G and frequency of Treg cells in treated 
      RRMS patients and healthy individuals. It seems that high level sHLA-G has been 
      instrumental in raising frequency of Treg cells in treated patients and could be 
      associated with remission of MS disease.
FAU - Alsahebfosoul, Fereshteh
AU  - Alsahebfosoul F
AD  - Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares 
      University, Tehran, Iran.
FAU - Zavaran Hosseini, Ahmad
AU  - Zavaran Hosseini A
AD  - Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares 
      University, Tehran, Iran.
FAU - Salehi, Rasoul
AU  - Salehi R
AD  - Department of Molecular Biology Faculty of Medicine, Isfahan University of 
      Medical Sciences, Tehran, Iran.
FAU - Etemadifar, Masood
AU  - Etemadifar M
AD  - Neurology Department, Faculty of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Esmaeil, Nafiseh
AU  - Esmaeil N
AD  - Department of Immunology, Faculty of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Jamshidian, Azam
AU  - Jamshidian A
AD  - Department of Immunology, Faculty of Medicine, Shahrekord University of Medical 
      Sciences, Shahrekord, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (HLA-G Antigens)
RN  - 0 (Protein Isoforms)
SB  - IM
MH  - Adult
MH  - Female
MH  - Flow Cytometry
MH  - HLA-G Antigens/*analysis
MH  - Humans
MH  - Male
MH  - Multiple Sclerosis, Relapsing-Remitting/etiology/*immunology
MH  - Protein Isoforms
MH  - T-Lymphocytes, Regulatory/*immunology
OTO - NOTNLM
OT  - Multiple sclerosis
OT  - Regulatory T cells
OT  - sHLA-G
EDAT- 2015/11/08 06:00
MHDA- 2016/05/14 06:00
CRDT- 2015/11/08 06:00
PHST- 2015/10/18 00:00 [accepted]
PHST- 2015/11/08 06:00 [entrez]
PHST- 2015/11/08 06:00 [pubmed]
PHST- 2016/05/14 06:00 [medline]
PST - ppublish
SO  - Iran J Allergy Asthma Immunol. 2015 Jun;14(3):298-305.