PMID- 26547395
OWN - NLM
STAT- MEDLINE
DCOM- 20161019
LR  - 20180816
IS  - 1600-0897 (Electronic)
IS  - 1046-7408 (Linking)
VI  - 75
IP  - 1
DP  - 2016 Jan
TI  - Reduced Circulating Concentration of Brain-derived Neurotrophic Factor is 
      Associated with Peri- and Post-implantation Failure following In Vitro 
      Fertilization-Embryo Transfer.
PG  - 36-41
LID - 10.1111/aji.12430 [doi]
AB  - PROBLEM: We evaluated associations between brain-derived neurotrophic factor 
      (BDNF) and neurotrophin-4 (NT4) and pregnancy outcome in women undergoing in 
      vitro fertilization-embryo transfer (IVF-ET). METHOD OF STUDY: Sera obtained on 
      days 24 and 28 of an IVF cycle from women with a live birth, spontaneous 
      abortion, biochemical pregnancy, not pregnant, or an ectopic pregnancy were 
      retrospectively analyzed for BDNF and NT4 by ELISA. RESULTS: Median BDNF levels 
      were higher in women with a live birth compared to women with an ectopic 
      pregnancy (P < 0.0001), spontaneous abortion (P < 0.0001), or a biochemical 
      pregnancy (P = 0.0004), but not in women who did not become pregnant. NT4 was 
      detected in <25% of sera and did not differ by outcome. There was no association 
      between BDNF level and oocyte or pre-transfer embryo parameters. CONCLUSION: 
      Decreased circulating BDNF early in an IVF cycle is associated with adverse peri- 
      and/or post-implantation events and subsequent pregnancy failure.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Ramer, Ilana
AU  - Ramer I
AD  - Department of Obstetrics and Gynecology, Division of Immunology and Infectious 
      Diseases, Weill Cornell Medical College, New York, NY, USA.
AD  - Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill 
      Cornell Medical College, New York, NY, USA.
FAU - Kruczek, Alexis
AU  - Kruczek A
AD  - Department of Obstetrics and Gynecology, Division of Immunology and Infectious 
      Diseases, Weill Cornell Medical College, New York, NY, USA.
FAU - Doulaveris, Georgios
AU  - Doulaveris G
AD  - Department of Obstetrics and Gynecology, Division of Immunology and Infectious 
      Diseases, Weill Cornell Medical College, New York, NY, USA.
FAU - Orfanelli, Theofano
AU  - Orfanelli T
AD  - Department of Obstetrics and Gynecology, Division of Immunology and Infectious 
      Diseases, Weill Cornell Medical College, New York, NY, USA.
FAU - Shulman, Brittney
AU  - Shulman B
AD  - Department of Obstetrics and Gynecology, Division of Immunology and Infectious 
      Diseases, Weill Cornell Medical College, New York, NY, USA.
FAU - Witkin, Steven S
AU  - Witkin SS
AD  - Department of Obstetrics and Gynecology, Division of Immunology and Infectious 
      Diseases, Weill Cornell Medical College, New York, NY, USA.
FAU - Spandorfer, Steven D
AU  - Spandorfer SD
AD  - Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill 
      Cornell Medical College, New York, NY, USA.
LA  - eng
PT  - Journal Article
DEP - 20151107
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Abortion, Spontaneous/*diagnosis
MH  - Adult
MH  - Biomarkers/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Embryo Implantation
MH  - Embryo Transfer
MH  - Female
MH  - Fertilization in Vitro
MH  - Humans
MH  - Live Birth
MH  - Nerve Growth Factors/*blood
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Pregnancy, Ectopic/*diagnosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - IVF outcome
OT  - implantation
OT  - neurotrophic factor 4
EDAT- 2015/11/09 06:00
MHDA- 2016/11/27 06:00
CRDT- 2015/11/09 06:00
PHST- 2015/02/23 00:00 [received]
PHST- 2015/08/24 00:00 [accepted]
PHST- 2015/11/09 06:00 [entrez]
PHST- 2015/11/09 06:00 [pubmed]
PHST- 2016/11/27 06:00 [medline]
AID - 10.1111/aji.12430 [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2016 Jan;75(1):36-41. doi: 10.1111/aji.12430. Epub 2015 Nov 
      7.