PMID- 26548428 OWN - NLM STAT- MEDLINE DCOM- 20160919 LR - 20181202 IS - 1744-4144 (Electronic) IS - 1385-4046 (Linking) VI - 29 IP - 7 DP - 2015 TI - The Minimum Clinically Important Difference in the Repeatable Battery for the Assessment of Neuropsychological Status. PG - 905-23 LID - 10.1080/13854046.2015.1107137 [doi] AB - OBJECTIVE: There is no established minimum clinically important difference (MCID) for the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) index and total scale scores. This study aimed to estimate the MCID for the RBANS index scores and total scale score. METHOD: Participants included 1,856 ethnic Chinese, older adults. Distribution- and anchor-based methods were used to estimate values for the MCID. Distribution-based estimates were calculated as the standard error of measurement (SEM) and .5 standard deviations (SD). For anchor-based estimates, we compared RBANS scores between the clinical dementia rating (CDR) scale no dementia and very mild dementia groups and between the clinical assessment of dementia (CAD) cognitively normal and mild cognitive impairment groups using regression models adjusting for demographic characteristics. RESULTS: Estimates from the CDR anchor were 7.79, 8.63, 10.74, 9.74, 5.61, and 3.77 for the total scale score, language, immediate memory, delayed memory, visuospatial/constructional, and the attention index, respectively. Estimates from the distribution-based methods were similar to the estimates based on the CDR, except for the language and attention indexes. Estimates from the CAD anchor were larger. CONCLUSIONS: We estimated the MCID for the total scale score, language, immediate memory, delayed memory, visuospatial/constructional, and attention indexes of the RBANS as 8, 9, 10, 10, 6, and 4 points, respectively. These estimates are best suited to discriminate between patient groups, for example, in a clinical trial setting. Further research is needed using longitudinal data to assess their applicability to assess within patient differences. FAU - Phillips, Rachel AU - Phillips R AD - a Biostatistics Department , Singapore Clinical Research Institute , Singapore , Singapore. FAU - Qi, Gao AU - Qi G AD - b Gerontological Research Programme, Faculty of Medicine , National University of Singapore , Singapore , Singapore. AD - c Department of Psychological Medicine , National University of Singapore , Singapore , Singapore. FAU - Collinson, Simon Lowes AU - Collinson SL AD - b Gerontological Research Programme, Faculty of Medicine , National University of Singapore , Singapore , Singapore. AD - d Department of Psychology , National University of Singapore , Singapore , Singapore. FAU - Ling, Audrey AU - Ling A AD - b Gerontological Research Programme, Faculty of Medicine , National University of Singapore , Singapore , Singapore. AD - c Department of Psychological Medicine , National University of Singapore , Singapore , Singapore. FAU - Feng, Lei AU - Feng L AD - b Gerontological Research Programme, Faculty of Medicine , National University of Singapore , Singapore , Singapore. AD - c Department of Psychological Medicine , National University of Singapore , Singapore , Singapore. FAU - Cheung, Yin Bun AU - Cheung YB AD - e Centre for Quantitative Medicine , Duke-National University of Singapore Graduate Medical School , Singapore , Singapore. AD - f Department of International Health , University of Tampere , Tampere , Finland. FAU - Ng, Tze-Pin AU - Ng TP AD - b Gerontological Research Programme, Faculty of Medicine , National University of Singapore , Singapore , Singapore. AD - c Department of Psychological Medicine , National University of Singapore , Singapore , Singapore. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20151107 PL - England TA - Clin Neuropsychol JT - The Clinical neuropsychologist JID - 8806548 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Attention MH - Cognitive Dysfunction/*diagnosis/*psychology MH - Dementia/*diagnosis/*psychology MH - Female MH - Humans MH - Language MH - Male MH - Memory, Short-Term MH - Middle Aged MH - *Neuropsychological Tests MH - Psychometrics MH - Repression, Psychology MH - Space Perception OTO - NOTNLM OT - Chinese. OT - Elderly/geriatrics/aging OT - Mild cognitive impairment OT - Minimum clinically important difference OT - Neuropsychological test EDAT- 2015/11/10 06:00 MHDA- 2016/09/20 06:00 CRDT- 2015/11/10 06:00 PHST- 2015/11/10 06:00 [entrez] PHST- 2015/11/10 06:00 [pubmed] PHST- 2016/09/20 06:00 [medline] AID - 10.1080/13854046.2015.1107137 [doi] PST - ppublish SO - Clin Neuropsychol. 2015;29(7):905-23. doi: 10.1080/13854046.2015.1107137. Epub 2015 Nov 7.