PMID- 26548545
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20201209
IS  - 1502-4725 (Electronic)
IS  - 0803-9488 (Linking)
VI  - 70
IP  - 4
DP  - 2016
TI  - Serum levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 
      (NT-3) in depressed patients with schizophrenia.
PG  - 267-71
LID - 10.3109/08039488.2015.1087592 [doi]
AB  - AIM: Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are 
      neurotrophins-proteins that induce the survival, development, and function of 
      neurons. Their role in the development of schizophrenia and mood disorders is 
      widely studied. This study was aimed to determine whether depression affects 
      levels of BDNF and NT-3 in patients with schizophrenia. METHODS: Data for 53 
      Caucasian adult hospitalized patients with chronic paranoid schizophrenia was 
      compared with 27 healthy subjects. Clinical symptoms were assessed using the 
      Positive and Negative Syndrome Scale (PANSS) and positive, negative and general 
      sub-scores, the Calgary Depression Scale for Schizophrenia (CDSS), the Hamilton 
      Depression Rating Scale (HDRS), and the Clinical Global Impressions scale (CGI). 
      Patients were defined as depressed (SHZ-DEP) with scores CDSS > 6 and HDRS > 7, 
      otherwise they were included into the non-depressed group (SHZ-nonDEP). RESULTS: 
      In total, 17 patients (32.1%) with schizophrenia met criteria for depression. 
      SHZ-DEP patients had higher scores in HDRS, CDSS, PANSS total, PANSS negative, 
      PANSS general and CGI (p < 0.001 for all comparisons). There were no differences 
      in BDNF or NT-3 levels between patients with schizophrenia and controls. BDNF 
      levels were lower in SHZ-DEP compared to SHZ-nonDEP: 18.82 +/- 5.95 versus 
      22.10 +/- 5.31 ng/mL, p = 0.045. NT-3 levels were higher in SHZ-DEP compared to 
      SHZ-nonDEP: 133.31 +/- 222.19 versus 56.04 +/- 201.28 pg/mL, p = 0.033. CONCLUSION: 
      There were no differences in neurotrophin levels between patients with 
      schizophrenia and controls. We found lower BDNF and higher NT-3 serum levels in 
      depressed patients with schizophrenia.
FAU - Wysokinski, Adam
AU  - Wysokinski A
AD  - a Department of Old Age Psychiatry and Psychotic Disorders , Medical University 
      of Lodz , Lodz , Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151107
PL  - England
TA  - Nord J Psychiatry
JT  - Nordic journal of psychiatry
JID - 100927567
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NTF3 protein, human)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder/*blood/complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factors/*blood
MH  - Neurotrophin 3
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*blood/complications
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF
OT  - NT-3
OT  - depression
OT  - schizophrenia
EDAT- 2015/11/10 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/11/10 06:00
PHST- 2015/11/10 06:00 [entrez]
PHST- 2015/11/10 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.3109/08039488.2015.1087592 [doi]
PST - ppublish
SO  - Nord J Psychiatry. 2016;70(4):267-71. doi: 10.3109/08039488.2015.1087592. Epub 
      2015 Nov 7.